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135篇 您的检索式：作者名="Kassir"

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	题名	作者	年代	出处	被引量
1	S1P/S1PR1 signaling differentially regulates the allogeneic response of CD4 and CD8 T cells by modulating mitochondrial fission显示文摘Graft-versus-host disease (GVHD) significantly contributes to patient morbidity and mortality after allogeneic hematopoietic cell transplantation (allo-HSCT). Sphingosine-1-phosphate (S1P) signaling is involved in the biogenetic processes of different immune cells. In the current study, we demonstrated that recipient sphingosine kinase 1 (Sphk1), but not Sphk2, was required for optimal S1PR1-dependent donor T-cell allogeneic responses by secreting S1P. Using genetic and pharmacologic approaches, we demonstrated that inhibition of Sphk1 or S1PR1 substantially attenuated acute GVHD (aGVHD) while retaining the graft-versus-leukemia (GVL) effect. At the cellular level, the Sphk1/S1P/S1PR1 pathway differentially modulated the alloreactivity of CD4+ and CD8+ T cells;it facilitated T-cell differentiation into Th1/Th17 cells but not Tregs and promoted CD4+ T-cell infiltration into GVHD target organs but was dispensable for the CTL activity of allogeneic CD8+ T cells. At the molecular level, the Sphk1/S1P/S1PR1 pathway augmented mitochondrial fission and increased mitochondrial mass in allogeneic CD4+ but not CD8+ T cells by activating the AMPK/AKT/mTOR/Drp1 pathway, providing a mechanistic basis for GVL maintenance when S1P signaling was inhibited. For translational purposes, we detected the regulatory efficacy of pharmacologic inhibitors of Sphk1 and S1PR1 in GVHD induced by human T cells in a xenograft model. Our study provides novel mechanistic insight into how the Sphk1/S1P/S1PR1 pathway modulates T-cell alloreactivity and validates Sphk1 or S1PR1 as a therapeutic target for the prevention of GVHD and leukemia relapse. This novel strategy may be readily translated into the clinic to benefit patients with hematologic malignancies and disorders.	Linlu Tian Yongxia Wu Hee-Jin Choi Xiaohui Sui Xinlei Li M.Hanief Sofi Mohamed Faisal Kassir Xiao Chen Shikhar Mehrotra Besim Ogretmen Xue-zhong Yu	2022	Cellular & Molecular Immunology2022，19，11：	2
2	Chloride-induced corrosion of reinforced concrete bridge decks显示文摘	Mumtaz K Kassir Michel Ghosn	2002	Cement and Concrete Research2002，，1：	1
3	Assessment of a palatal approach-anteri-or superior alveolar(P-ASA)nerve block with the wand in pae-diatric dental patients显示文摘	RAM D KASSIRER J	2006	Int J Paediatr Dent2006，16，5：	1
4	Pain in muhiple sclerosis: a biopsychosocial perspective 显示文摘	Kerns R D Kassirer M Otis J	2002	J Rehabil Res Dev2002，39，：	1
5	Three-dimensional stress distri- bution around an elliptical crack under arbitrary loa- dings显示文摘	Kassir M K Sih G C	1966	Journal of Applied Mechanics1966，33，3：	1
6	Teaching clinical reasoning:case-based and coached显示文摘	Kassirer JP	2010	Acad Med2010，85，7：	1
7	Fine grinding of silicon wafers : a mathematical model for grinding marks 显示文摘	Chidambaram S Pei Z J Kassir S	2003	International Journal of Machine Tools and Manufacture2003，43，：	1
8	Fine grinding of silicon wafers:a mathematical model for grinding marks显示文摘	Chidambaram S Pei Z J and Kassir S	2003	International Journal of Machine Tools & Manufacture2003，43，：	1
9	Extensive necrosis after injection of hyalurenic acid filler: case report and review of the literature 显示文摘	Kassir R Kolluru A Kassir M	2011	J Cosmet Dermatol2011，10，3：	1
10	A simple and highly efficient procedure for rescuing autonomous plasmids from yeast显示文摘	Robzyk K Kassir Y	1992	Nucleic Acids Res1992，20，：	1
11	Intense pulsed light for the treatment ofrosacea and telangiectasias显示文摘	Kassir R	2011	Cosmet Laser Ther2011，13，5：	1
12	Recurrent nephrotic syndrome after transplantation:Early treatment with plasmaphaeresis and cyclophosphamide显示文摘	Cochat P Kassir A Colon S	1993	Pediatr Nephrol1993，7，1：	1
13	Chloride-Induced Corrosion of Reinforced Concrete Bridge Decks 显示文摘	Mumtaz K Kassir Michel Ghosn	2002	Cement and Concrete Research2002，32，1：	1
14	A simple and highly efficient procedure for rescuing autonomous plasmids from yeast 显示文摘	Robzyk K Kassir Y	1992	Nucleic Acids Res1992，20，：	1
15	Assessment of a palatal approach-anterior superior alveolar (P-ASA)nerve block with the Wand in paedi- attic dental patients 显示文摘	Ram D Kassirer J	2006	Int J Paediatr Dent2006，16，5：	1
16	Assessment of a palatal approach-anterior superior alveolar(P-ASA)nerve block with the Wand in paedi- atric dental patients 显示文摘	Ram D Kassirer J	2006	Int J Paediatr Dent2006，16，5：	1
17	Vertical vibration of a circular footing on a saturated half space 显示文摘	KASSIR M K BANDYOPADYAY K K XU J	1989	International Journal of Engineering Science1989，27，：	1
18	Violations of the embargo and a new policy on early publicity 显示文摘	Kassirer J P Angell M	1994	N Engl J Med1994，330，22：	1
19	Evaluating hemorrhage in renal cell carcinoma using susceptibility weighted imaging显示文摘	Xing W He X Kassir M A Chen J Ding J Sun J	2013	PLoS One2013，8，57：	1
20	Interaction functions of a rigid strip bonded to saturated elastic half-space显示文摘	Xu J	1988	International Joural of Solids and Structures1988，24，9：	1

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