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| 1 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 2 | COX-2 selective non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease显示文摘 | Wayne A Ray C Michael Stein James R Daugherty Kathi Hall Patrick G Arbogast Marie R Griffin | 2002 | The Lancet2002，，9339： | 1 |
| 3 | Nonirtherited risk factors and congenital cardiovascular defects 显示文摘 | Kathy J J Adolfo C Jeffrey A F | 2007 | Circulation2007，115，： | 1 |
| 4 | CT healthcare failure mode effect analy- sis(HFMEA) :The misadministration of IV contrast in outpatients 显示文摘 | Kathy OP Ben A June C | 2007 | Radiology Management2007，29，1： | 1 |
| 5 | Sleeppromotion in hospitalized elder 显示文摘 | Corey L Nagel Megan B Markie Kathy C Richards | 2003 | Mcd Surg Nursing2003，，12： | 1 |
| 6 | Sleep promotion in hospitalized elder显示文摘 | Corey L Nagel Megan B Markie Kathy C Richards | 2003 | Med Surg Nursing2003，，12： | 1 |
| 7 | Evolution of an Agricul- tural Innovation: The N-Trak Soil Nitrogen Test Adopt and Discon- tinue, or Reject? 显示文摘 | Kathy S K Michael C Stephen G | 2001 | Technology in Society2001，23，1： | 1 |
| 8 | Using CFD to improve aeroengine air/oil separator design 显示文摘 | Stephen C E Kathy H Wang S Y | 2002 | Proceedings of PVP20022002，，： | 1 |
| 9 | Rehabilitation starts in the in- tensive care unit 显示文摘 | Nathan R Kathy P Daniel C | 2012 | Crit Care Nurs Q2012，35，3： | 1 |
| 10 | Wear performance of ultrahigh molecular weight polyethylene/quartz composites显示文摘 | Xie X L Tang C Y Kathy Y Y Chan | 2003 | Biomaterials2003，24，： | 1 |
| 11 | The gene-silencing efficiency of siRNA is strongly dependent on the local structure of mRNA at the targeted region显示文摘 | KATHY Q L DONALD C C | 2004 | Biochemical and Biophysical Research Communication2004，318，1： | 1 |
| 12 | Lipidlowering effects of ethyl 2-phenacyl-3-aryl-1H-pyrrole-4-carboxylates in rodents 显示文摘 | JUSTIN M H KATHY O C ADAM G | 2004 | Molecules2004，9，3： | 1 |
| 13 | Levels of dioxins,dibenzofurans,PCB and DDE congeners in pooled food samples collected in 1995 at supermarkets across the United States显示文摘 | Paul C Kathy B | 1997 | Chemosphere1997，34，： | 1 |
| 14 | Aboriginal urbanization and rights in Canada:examining implications for health 显示文摘 | Laura C Senese Kathi Wilson | 2013 | Journal of Social Science & Medicine2013，，8： | 1 |
| 15 | Evaluation of analytical methods for determining pesticides in baby foods and adult duplicate-diet samples显示文摘 | Jane C Chuang Kathy Hart Joseph S Chang Lawrence E Boman Jeanette M Van Emon Allan W Reed | 2001 | Analytica Chimica Acta2001，，1： | 1 |
| 16 | Antiviral medications to prevent cytomegalovirus disease and early death in recipients of solid-organ transplants: a systematic review of randomised controlled trials显示文摘 | Elisabeth M Hodson Cheryl A Jones Angela C Webster Giovanni FM Strippoli Peter G Barclay Kathy Kable Dushyanthi Vimalachandra Jonathan C Craig | 2005 | The Lancet2005，，9477： | 1 |
| 17 | Compliance to the fair information practices: how the Fortune 500 handling online privacy disclosures 显示文摘 | Kathy S S Gerald C K | 2006 | Information & Management2006，43，： | 1 |
| 18 | Therapeutic communities for addictions : a review of their effectiveness from a recovery - oriented perspective 显示文摘 | Wouter V Kathy C Mieke A | 2013 | Scientific World J2013，，42： | 1 |
| 19 | Cadmium telluride quantum dots cause oxidative stress leading to extrinsic and intrinsic apoptosis in hepatocellular carcinoma HepG2 cells 显示文摘 | KATHY C NGUYEN WILLIAM G WILLMORE AZAM F TAYABA- LI | 2013 | Toxicology2013，306，： | 1 |
| 20 | Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III randomised controlled trial显示文摘 | Kathy S Albain R Suzanne Swann Valerie W Rusch Andrew T Turrisi Frances A Shepherd Colum Smith Yuhchyau Chen Robert B Livingston Richard H Feins David R Gandara Willard A Fry Gail Darling David H Johnson Mark R Green Robert C Miller Joanne Ley Willliam T | 2009 | The Lancet . 2009 (9687)2009，，9687： | 1 |
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