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| 1 | Dupilumab治疗常年性变应性鼻炎并发哮喘患者的疗效和安全性显示文摘背景Dupilumab是一种抗IL-4受体α亚基的抗体,可以阻断IL-4/IL-13的信号转导。IL-4/IL-13是2型/Th2型免疫疾病(如特应性/过敏性疾病)的关键驱动因子。一项重要的2b期临床研究(NCT01854047)显示,在使用了中高剂量吸入激素联合长效β2受体激动剂(ICS/LABA)后仍控制不佳的持续性哮喘患者中,dupilumab可减少哮喘重度急性发作,改善患者的肺功能和生活质量,且耐受性良好。目的探讨在哮喘并发常年性变应性鼻炎(PAR)患者中,dupilumab对SNOT-22的总分及其中变应性鼻炎(AR)相关症状评分的影响。方法对2b临床研究中每2周(q2w) 200 mg和300 mg dupilumab治疗后的数据进行析因分析。这两种剂量的dupilumab目前正在3期临床研究(NCT02414854)中进行验证。PAR定义为:在研究开始时,患者出现对典型的常年性抗原产生特异性应答(Ig E≥0. 35 Ku/L)。结果总共241例(61%)患者患有PAR。与安慰剂相比,每两周300 mg dupilumab显著改善了在哮喘并发PAR的患者中SNOT-22的总分(最小二乘平均差,-5. 98; 95%CI,-10. 45~-1. 5; P=0. 009)和4项AR相关症状的评分(鼻塞,-0. 60; 95%CI,-0. 96~-0. 25;流鼻涕,-0. 67; 95%CI,-1. 04~-0. 31;打喷嚏,-0. 55; 95%CI,-0. 89~-0. 21;鼻后分泌物,-0. 49;95%CI,-0. 83~-0. 16; 4项评分都P <0. 01);每两周200 mg dupilumab治疗减少了并发PAR的患者的SNOT-22总分(-1. 82; 95%CI,-6. 46~2. 83; P=0. 443)和AR相关的症状评分,但与安慰剂相比无统计学差异。在无PAR的哮喘患者中,dupilumab与安慰剂治疗这些评分无差异。结论每两周300 mg dupilumab治疗显著改善了在控制不佳的持续性哮喘并发PAR患者中的AR相关的鼻部症状。 | Steven F.Weinstein Rohit Katial Shyamalie Jayawardena Gianluca Pirozzi Heribert Staudinger Laurent Eckert Vijay N.Joish Nikhil Amin Jaman Maroni Paul Rowe Neil M.H.Graham Ariel Teper 黄庭萱(翻译) 刘春涛(审校) | 2018 | 中华临床免疫和变态反应杂志2018，12，5： | 2 |
| 2 | Human papilloma virus associated with solitary squamous papilloma complicated by bronchiectasis and bronchia stenosis显示文摘 | Katial R K Ranlett R Whitlock W L | 1994 | Chest1994，106，6： | 1 |
| 3 | Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma显示文摘 | BusseWW Katial R Gossage D | 2010 | J Allergy Clin Immunol2010，125，6： | 1 |
| 4 | Long-term treatment with fluticasone propionate/salmeterol via Diskus improves asthma control versus fluticasone propionate alone显示文摘 | Katial RK Bernstein D Prazma CM | 2011 | Allergy Asthma Proc2011，32，2： | 1 |
| 5 | Adding montelukast to fl uticasone propionate/salmeterol for control of asthma and seasonal allergic rhinitis显示文摘 | Katial RK Oppenheimer J Ostrom NK | 2010 | Allergy Asthma Proc2010，31，1： | 1 |
| 6 | Cell mediated immune response to tubereulosis antigens:comparison of skin testing and measurement of in vitro gamma interfer on produetion in whole blood culture显示文摘 | Katial R K Hershey J Purohit S T | | 0，，： | 1 |
| 7 | Allergic rhinitis substantially impacts patient quality of life:findings from the Nasal Allergy Survey Assessing Limitations显示文摘 | Meltzer EO Gross GN Katial R | 2012 | J Fam Pract2012，61，2： | 1 |
| 8 | Cockroach allergy显示文摘 | Katial RK | 2003 | Immunol Allergy Clin North Am2003，23，3： | 1 |
| 9 | Deleterious affects of electron beam radiation on allergn extracts显示文摘 | Katial R K Grier T J Hazelhurst D M 'Hershey J Engler R J M | 2002 | Journal of Allergy Clinical Immunology2002，110，： | 1 |
| 10 | Update on Side Effects from Common Vaccines 显示文摘 | Song B J Katial RK | 2004 | CurrAllergy Asthma Rep2004，4，6： | 1 |
| 11 | Exhaled nitric oxide 显示文摘 | Stewart L Katial RK | 2012 | Immunol Allergy Clin North Am2012，32，3： | 1 |
| 12 | Update on Side Effects from Common Vaccines 显示文摘 | Song B J Katial RK | 2004 | Curt Allergy Asthma Rep2004，4，： | 1 |
| 13 | Safety profile, phar- macokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma 显示文摘 | Busse WW Katial R Gossage D et ol | 2010 | J Allergy Clin Immunol2010，125，6： | 1 |
| 14 | Probenecid hypersensitivity in AIDS:a case report显示文摘 | Myers KW Katial RK Engler RJ | 1998 | Ann Allergy Asthma Immunol1998，80，5： | 1 |
| 15 | Cell-mediated immune response to tuberculosis antigens: comparison of skin testing and measurement of in vitro gamma interferon production in whole-blood culture 显示文摘 | Katial RK Hershey J Purohit-Seth T | 2001 | Clih Diagn Lab Immunol2001，8，2： | 1 |
| 16 | Deleterious affects of eleetron beam radiation on allergen extracts 显示文摘 | Katial RK Grier TJ Hazelhurst DM | 2002 | Journal Allergy Clinical Immunology2002，8，： | 1 |
| 17 | Antihistamine therapy in allergic rhinitis显示文摘 | Hoyte FC Katial RK | 2011 | Immunol Allergy Clin North Am2011，31，3： | 1 |
| 18 | Deleterious effects of electron beam radiation on allergen extracts显示文摘 | katial R K Grier T J Hazelhurst D M | 2002 | Journal Allergy Clinical Immunology2002，，8： | 1 |
| 19 | Immu- nogenicity and safety testing of a group B intranasal me- ningococcal native outer membrane vesicle vaccine 显示文摘 | KATIAL R K BRANDT B L MORAN E E | 2002 | Infect Immun2002，70，2： | 1 |
| 20 | Antihistamine therapy in allergic rhinitis显示文摘 | HOYTE F C KATIAL R K | 2011 | Immunol Allergy Clin North Am2011，31，： | 1 |
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