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| 1 | Evaluation of the effect of pyrrolidine dithiocarbamate in suppressing inflammation in mice with dextran sodium sulfate-induced colitis显示文摘AIM: To evaluate the effect of pyrrolidine dithio- carbamate (PDTC; an NF-κB inhibitor) administered at low (50 mg/kg) and high (100 mg/kg) doses in suppressing colitis in mice with dextran sodium sulfate (DSS)-induced colitis. METHODS: Mice were divided into a DSS-untreated group (normal group), DSS-treated control group, DSS+PDTC-treated groupⅠ(low-dose group), and DSS+PDTC-treated groupⅡ (high-dose group). In each group, the disease activity index score (DAI score), intestinal length, histological score, and the levels of activated NF-κB and inflammatory cytokines (IL-1β and TNF-α) in tissue were measured. RESULTS: The DSS+PDTC-treated groupⅡ exhibited suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels were significantly lower in DSS+PDTC- treated groupⅡ. CONCLUSION: These findings suggest that PDTC is useful for the treatment of ulcerative colitis. | Ichiro Hirata Shingo Yasumoto Ken Toshina Takuya Inoue Takashi Nishikawa Naoko Murano Mitsuyuki Murano Fang-Yu Wang Ken-ichi Katsu | 2007 | World Journal of Gastroenterology2007，13，11： | 20 |
| 2 | Complete response to multidisciplinary therapy in a patient with primary gastric choriocarcinoma显示文摘Primary gastric choriocarcinoma is a rapidly growing neoplasm with an average survival of several months in untreated patients.Gastrectomy with lymph node dissection followed by chemotherapy is the treatment of choice.Regimens used for gastric adenocarcinoma are usually selected.However,median survival remains less than six months.In this case report,we describe a case of primary gastric choriocarcinoma with a clinical complete response to multidisciplinary treatment including surgery,chemotherapy,and radiofrequency ablation(RFA).The patient was originally referred for general malaise.Esophagogastroduodenoscopy demonstrated a large tumor occupying the fornix,and total gastrectomy with lymph node dissection was performed.Seven days later,multiple liver metastatic recurrences with high serum levels of beta-human chorionic gonadotropin(β-hCG) were recognized.Chemotherapy with a gonadal choriocarcinoma regimen consisting of etoposide,methotrexate,actinomycin D,cyclophosphamide,and vincristine(EMA/CO),was initiated.After three cycles,serum β-hCG decreased markedly and the tumors disappeared.Six months later,multiple lung metastatic recurrences were found.After one cycle of EMA/CO,only one nodule remained.Computed tomography-guided RFA was performed for this oligometastatic tumor.The patient has been alive with no evidence of disease for 10 years after the initial diagnosis.To the best of our knowledge,this patient with recurrent primary gastric choriocarcinoma has achieved the longest survival.The present case is the first report of choriocarcinoma metastatic to the lung successfully treated with RFA.From our retrospective analysis of recurrent or unresectable primary gastric choriocarcinoma,we propose that gonadal choriocarcinoma regimens can be considered as first-line for primary gastric choriocarcinoma. | Kazuhiro Takahashi Shigeki Tsukamoto Ken Saito Nobuhiro Ohkohchi Katsu Hirayama | 2013 | World Journal of Gastroenterology2013，19，31： | 6 |
| 3 | 早期大肠癌的内镜下分类:中日对比研究显示文摘目的对中日两国内镜医师关于早期大肠癌的内镜下分类意见进行对比分析,找出其异同点。方法选择 7例早期大肠癌病例,邀请中日各 5名内镜医师阅读其内镜彩色照片及相关资料,各自提出自己的诊断意见及诊断依据。最后,将收集的诊断意见进行对比分析。结果日方医师诊断为Ⅱ型 (表面型 )的某些病变,中国医师则认为是Ⅰ型 (隆起型 )。对于表面隆起伴中央凹陷的病变,两国医师大都根据隆起部分与凹陷部分之面积比,相应诊断为Ⅱ a+Ⅱ c或Ⅱ c+Ⅱ a。日本医师近年使用了一些新的概念,比如Ⅱ a+ depresion,LST(laterally spreading tumor)等,在中国分类中尚未采用。结论中日两国医师关于早期大肠癌的内镜分类判定标准上存在一定的差异,有必要广泛开展国际学术交流与合作,以期建立一个统一的分类标准。 | 汪芳裕 朱人敏 Ichiro Hirata Ken-ichi Katsu 于中麟 张志宏 徐肇敏 萧树东 | 2000 | 中华消化内镜杂志2000，17，6： | 5 |
| 4 | Increased prevalence of intestinal inflammation in patients with liver cirrhosis显示文摘AIM To investigate the pathophysiology of the digestive tract in patients with liver cirrhosis.METHODS In 42 cirrhotic patients and 20control subjects, the following fecal proteinswere measured by enzyme-linkedimmunosorb6nt assay: albumin (Alb ),transferrin (Tf), and al-antitrypsin (a,-AT) as amarker for intestinal protein l0ss, hemoglobin(Hb) for bleeding, PMN-eIastase for intestinalinflammation, and secretory lgA for intestinalimmunity.RESULTS The fecaI concentrations of Hb, Alb,Tf, al-AT, and PMN’eIastase were increased in13 (3l%), 8(19%), l0(24%), 6(14%), and 1l(26%) cases among 42 patients, resPectiveIy.F6cal concentration of secretory IgA wasdecreased in 7 (l7%) of 42 patients. However,these fecal concentrations were not related tothe severity or etiology of liver cirrhosis. Theserum Alb level was significantIy decreased inpatients with intestinal protein Ioss c0mpared tothat in patients without intestinal protein loss.CONCLUSION These findings suggest that: rob6sides the weIl’known pathological conditions,Such as bleeding and protein loss, intestinaIinflammati0n and decreased intestinaI immunityare found in cirrhotic patients, @ intestinalprotein loss contributes to hypoalbuminemia incirrhotic patients, and @ intestinaI inflammationshouId not b6 0verlooked in cirrhotic patients,since it may contribute to or cause intestinalprotein Ioss and oth6r various pathologicalconditions. | Saitoh O Sugi K Lojima K Matsumoto H Nakagawa K Kayazawa M Tanaka S Teranishi T Hirata I Katsu Ki K | 1999 | World Journal of Gastroenterology1999，5，5： | 2 |
| 5 | Perforating veins in recurrent esophageal varices evaluated by endoscopic color Doppler ultrasonography with a galactose-based contrast agent显示文摘 | Takahiro Sato Katsu Yamazaki Jouji Toyota Yoshiyasu Karino Takumi Ohmura Jun Akaike Yasuaki Kuwata Toshihiro Suga | 2004 | Journal of Gastroenterology2004，，5： | 2 |
| 6 | Application of ecotoxicogenomics for studying endocrine disruption in vertebrates and invertebrates显示文摘 | Iguchi T Watanabe H Katsu Y | 2006 | Environmental Health Perspectives2006，114，1： | 1 |
| 7 | Antibacterial activated carbons prepared from pitch containing organometallics显示文摘 | HISHI TAMAI NOBUGOSHI KATSU | 2001 | Carbon2001，，39： | 1 |
| 8 | NADPH oxidase mediates striatal neuronal injury after transient global cerebral ischemia 显示文摘 | YOSHIOKA H NIIZUMA K KATSU M | 2011 | J Cereb Blood Flow Metab2011，31，3： | 1 |
| 9 | Beta 22 and beta 2 adrenergic re- ceptor polymorphisms are related to the onset of weight gain and blood pressure elevation over 5 years显示文摘 | Masuo K Katsu YA Fu Y | 2005 | Circulation2005，111，： | 1 |
| 10 | Diagnosis of acute myocardial ischemia by speckle tracking echocardiography- Acomparative animal study 显示文摘 | AYA E KATSU T KOICHI T | 2008 | Circulation2008，11，8： | 1 |
| 11 | Isolation and characterization of goldfish Y box protein, a germ- cell-specific RNA-hinding protein 显示文摘 | Katsu Y Yamashita M Nagahama Y | 1997 | European Journal of Biochemistry1997，249，3： | 1 |
| 12 | The differences in scenic perception of forest visitors through their attributes and recreational,activity显示文摘 | KATSUE F | 2006 | Landscape and Urban Planning2006，75，2： | 1 |
| 13 | Tissue-specific expression of Clec2g in mice显示文摘 | Katsu Y Iguchi T | 2006 | Eur J Cell Biol2006，85，5： | 1 |
| 14 | A Granulomatous Liver Abscess Which Developed After a Toothpick Penetrated the Gastrointestinal Tract: Report of a Case显示文摘 | Shigeo Kanazawa Katsu Ishigaki Takashi Miyake Atsuhisa Ishida Atsushi Tabuchi Kazuo Tanemoto Tsukasa Tsunoda | 2003 | Surgery Today2003，，4： | 1 |
| 15 | 大鼠降结肠上皮细胞γ-氨基丁酸及谷氨酸脱羧酶的表达与意义显示文摘目的检测γ-氨基丁酸(gamma-aminobutyric acid,GABA)和谷氨酸脱羧酶(glutamic acid decarboxylase,GAD)在大鼠降结肠上皮的表达及分布特征,并探讨GABA与上皮细胞分化增殖的关系。方法用免疫荧光及激光共聚焦显微扫描技术,检测GABA、GAD65及GAD67在大鼠降结肠上皮中的表达,并以麦芽凝聚素组织化学染色与免疫荧光结合的双重染色显示GABA和GAD65表达细胞的分布特征。同时,用RT-PCR方法检测GAD mRNA的表达。此外,用3H-胸腺嘧啶放射自显影及增殖细胞核抗原(PCNA)免疫组化方法显示降结肠上皮的增殖带。结果RT-PCR显示降结肠粘膜中GAD65及GAD67mRNA均为阳性。GABA及GAD65免疫反应阳性细胞主要分布在降结肠的腔面和隐窝的上1/3上皮细胞的胞浆,而GAD67阳性细胞仅分布腔面,此外,GABA及GAD65阳性染色也见于黏膜固有层。双重染色显示杯状细胞中GABA及GAD65均为阴性3。H-胸腺嘧啶及PCNA标记阳性细胞主要在隐窝的中下段。结论GABA及GAD65分布在大鼠降结肠上皮的成熟带及功能带,GABA系统可能参与上皮细胞的分化与增殖的调节。 | 汪芳裕 Maemura Kentaro 朱人敏 Hirata Ichiro Katsu Kenichi Watanabe Masahito | 2007 | 中国组织化学与细胞化学杂志2007，16，3： | 1 |
| 16 | Novel synthetic collagen fibers,poly(PHG),stimulateplatelet aggregation through glycoprotein VI显示文摘 | Inoue Osamu Suzuki-Inoue Katsue Shinoda Daisuke etal | 2009 | FEBSLetters2009，583，1： | 1 |
| 17 | Hemoglobin-in- duced oxidative stress contributes to matrix metallopro- teinase activation and blood-brain barrier dysfunction in vi- vo显示文摘 | Katsu M Niizuma K Yoshioka H | 2010 | J Cereb Blood Flow Metab2010，30，12： | 1 |
| 18 | Essentialin vivo roles of the platelet activation receptor CLEC-2 in tumour metastasis, lymphangiogenesis and thrombus formation显示文摘 | Katsue Suzttki-Inoue | 2011 | J Biochem2011，150，2： | 1 |
| 19 | Photocarrier injection effect on double exchange ferromagnetism in (La,Sr) MnO3/SrTiO3-Nb heterostructure显示文摘 | KATSU H TANAKA H KAWAI T | 2000 | Appl Phys Lett2000，76，： | 1 |
| 20 | Simple preparation of TiO2 particles dispersed activated carbons and their photo-sterilization activity显示文摘 | Tamai H Katsu N Ono K | 2002 | Journal of Materials Science2002，37，： | 1 |
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