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| 1 | Role of diffusion-weighted magnetic resonance imaging in the differential diagnosis of focal hepatic lesions显示文摘AIM:To evaluate the utility of diffusion-weighted im-aging(DWI)in screening and differential diagnosis of benign and malignant focal hepatic lesions.METHODS:Magnetic resonance imaging(MRI)ex-aminations were performed using the Signa Excite Xl Twin Speed 1.5T system(GE Healthcare,Milwaukee,WI,USA).Seventy patients who had undergone MRI of the liver [29 hepatocellular carcinomas(HCC),four cholangiocarcinomas,34 metastatic liver cancers,10 hemangiomas,and eight cysts] between April 2004 and August 2008 were retrospectively evaluated.Visu-alization of lesions,relative contrast ratio(RCR),and apparent diffusion coefficient(ADC)were compared between benign and malignant lesions on DWI.Su-perparamagnetic iron oxide(SPIO)was administered to 59 patients,and RCR was compared pre-and post-administration.RESULTS:DWI showed higher contrast between ma-lignant lesions(especially in multiple small metastatic cancers)and surrounding liver parenchyma than did contrast-enhanced computed tomography.ADCs(mean ± SD × 10-3 mm2/s)were signif icantly lower(P < 0.05)in malignant lesions(HCC:1.31 ± 0.28 and liver me-tastasis:1.11 ± 0.22)and were signifi cantly higher in benign lesions(hemangioma:1.84 ± 0.37 and cyst:2.61 ± 0.45)than in the surrounding hepatic tissues.RCR between malignant lesions and surrounding he-patic tissues signifi cantly improved after SPIO adminis-tration,but RCRs in benign lesions were not improved.CONCLUSION:DWI is a simple and sensitive method for screening focal hepatic lesions and is useful for dif-ferential diagnosis. | Naoto Koike Akihiro Cho Katsuhiro Nasu Kazuhiko Seto Shigeyuki Nagaya Yuji Ohshima Nobuhiro Ohkohchi | 2009 | World Journal of Gastroenterology2009，15，46： | 38 |
| 2 | Review of research on agricultural vehicle autonomous guidance显示文摘A brief review of research in agricultural vehicle guidance technologies is presented.The authors propose the conceptual framework of an agricultural vehicle autonomous guidance system,and then analyze its device characteristics.This paper introduces navigation sensors,computational methods,navigation planners and steering controllers.Sensors include global positioning systems(GPS),machine vision,dead-reckoning sensors,laser-based sensors,inertial sensors and geomagnetic direction sensors.Computational methods for sensor information are used to extract features and fuse data.Planners generate movement information to supply control algorithms.Actuators transform guidance information into changes in position and direction.A number of prototype guidance systems have been developed but have not yet proceeded to commercialization.GPS and machine vision fused together or one fused with another auxiliary technology is becoming the trend development for agricultural vehicle guidance systems.Application of new popular robotic technologies will augment the realization of agricultural vehicle automation in the future. | Ming Li Kenji Imou Katsuhiro Wakabayashi Shinya Yokoyama | 2009 | International Journal of Agricultural and Biological Engineering2009，2，3： | 21 |
| 3 | Does Helicobacter pylori eradication therapy for peptic ulcer prevent gastric cancer?显示文摘AIM:To investigate the effects of Helicobacter pylori (H pylori)eradication therapy for treatment of peptic ulcer on the incidence of gastric cancer. METHODS:A multicenter prospective cohort study was conducted between November 2000 and December 2007 in Yamagata Prefecture,Japan.The study included patients with H pylori-positive peptic ulcer who decided themselves whether to receive H pylori eradication(eradication group)or conventional antacid therapy(non-eradication group).Incidence of gastric cancer in the two groups was determined based on the results of annual endoscopy and questionnaire surveys,as well as Yamagata Prefectural Cancer Registry data,and was compared between the two groups and by results of H pylori therapy.RESULTS:A total of 4133 patients aged between 13 and 91 years(mean 52.9 years)were registered,and 56 cases of gastric cancer were identified over a mean follow-up of 5.6 years.The sex-and age-adjusted incidence ratio of gastric cancer in the eradication group, as compared with the non-eradication group,was 0.58 (95%CI:0.28-1.19)and ratios by follow-up period(<1 year,1-3 years,>3 years)were 1.16(0.27-5.00),0.50 (0.17-1.49),and 0.34(0.09-1.28),respectively.Longer follow-up tended to be associated with better prevention of gastric cancer,although not to a significant extent.No significant difference in incidence of gastric cancer was observed between patients with successful eradication therapy(32/2451 patients,1.31%)and those with treatment failure(11/639 patients,1.72%).Among patients with duodenal ulcer,which is known to be more prevalent in younger individuals,the incidence of gastric cancer was significantly less in those with successful eradication therapy(2/845 patients,0.24%)than in those with treatment failure(3/216 patients,1.39%). CONCLUSION:H pylori eradication therapy for peptic ulcer patients with a mean age of 52.9 years at registration did not significantly decrease the incidence of gastric cancer. | Katsuhiro Mabe Mikako Takahashi Haruhumi Oizumi Hideaki Tsukuma Akiko Shibata Kazutoshi Fukase Toru Matsuda Hiroaki Takeda Sumio Kawata | 2009 | World Journal of Gastroenterology2009，15，34： | 10 |
| 4 | Long-term prognostic impact of circulating tumour cells in gastric cancer patients显示文摘AIM To analyse the long-term prognostic impact of circulating tumour cells(CTCs) in gastric cancer patients who underwent surgery. METHODS A 7.5-m L peripheral vein blood sample was obtained from each patient with treatment-negative gastric adenocarcinoma before surgery. OBP-401, a telomerasespecific, replication-selective, oncolytic adenoviral agent carrying the green fluorescent protein gene, was used to label CTCs. Correlations between the number of CTCs and clinical end points were evaluated. RESULTS The median follow-up period of the surviving patients with gastric cancer was 60 mo. The CTC number tended to increase concomitantly with disease progression. The overall survival of patients with more than five CTCs in 7.5-m L of peripheral blood was lower than that of patients with five or less CTCs, although the difference was not significant(P = 0.183). A significant difference in relapse-free survival was found between patients with more than five and those with five or less CTCs(P = 0.034).CONCLUSION A lower number of CTCs was correlated with higher relapse-free survival rates in patients. Detection of CTCs using OBP-401 may be useful for predicting prognosis in gastric cancer. | Hiroaki Ito Jun Sato Yukio Tsujino Noriko Yamaguchi Satoshi Kimura Keigo Gohda Katsuhiro Murakami Manabu Onimaru Tohru Ohmori Fumihiro Ishikawa Haruhiro Inoue | 2016 | World Journal of Gastroenterology2016，22，46： | 8 |
| 5 | A visible light-driven plasmonic photocatalyst显示文摘We demonstrate a bottom-up approach to fabricating a visible light-driven titania photocatalyst device bearing an embeddedtwo-dimensional (2D) array of gold nanoparticles (AuNPs) as a near-field light-generating layer. The device is a layered structureprepared by depositing a 2D array of AuNPs on a transparent conductive substrate (10 nm indium tin oxide (ITO) layer on quartz),coating the 2D array of AuNPs with a monolayer of trimethoxyoctylsilane (TMOS), and depositing titania nanocrystals on the anchoringmolecule (TMOS) layer. The visible light activity of the device was tested using photocatalytic degradation of methylene blue (MB) byilluminating the device with visible light (700 nm light) and ultraviolet (UV) light (250–380 nm). The localized surface plasmonresonance peak of the 36 nm AuNP 2D array is around 700 nm with a full-width at half-maximum of 350 nm. In comparison with othercontrol samples, the device showed the highest photocatalytic activity with visible irradiation, which was 1.7 times higher than that oftitania with UV irradiation. The origin of the visible light activity was confirmed by both quadratic incident light power dependency andaction spectrum to be plasmon-induced (near-field enhancement by AuNPs) two-photon absorption. | Francesca Pincella Katsuhiro Isozaki Kazushi Miki | 2014 | Light(Science & Applications)2014，3，1： | 7 |
| 6 | Age-dependent eradication of Helicobacter pylori in Japanese patients显示文摘AIM:To determine the general risk factors affecting the failure rate of first-line eradication therapy in Japanese patients with Helicobacter pylori(H.pylori)infection.METHODS:The present study enrolled 253 patients who had an H.pylori infection,underwent gastroendoscopy,and were treated with H.pylori eradication therapy.Eradication therapy consisted of 30 mg lansoprazole plus 750 mg amoxicillin and 400 mg clarithromycin twice daily for 7 d.All of the patients underwent a 13 C urea breath test at least 1 mo after the completion of eradication therapy.The current study investigated the independent factors associated with successful H.pylori eradication using a multiple logistic regression analysis.RESULTS:The overall success rate in the patients was 85.8%.Among the general factors examined in the multivariate analyses,only having an age less than 50 years was found to be significantly associated with a poor response to H.pylori eradication.Moreover,side effects were the only clinical factors in the patients who were under 50 years of age that significantly influenced the poor response to H.pylori eradication.CONCLUSION:H.pylori-positive elderly patients should undergo eradication therapy.In addition,it is necessary to improve H.pylori eradication therapy in younger patients. | Satoshi Mamori Akihiro Higashida Fumiaki Kawara Katsuhiro Ohnishi Akihiko Takeda Eri Senda Cho Ashida Hajime Yamada | 2010 | World Journal of Gastroenterology2010，16，33： | 7 |
| 7 | A prospective randomized trial of lafutidine vs rabeprazole on post-ESD gastric ulcers显示文摘AIM:To compare the effects of rabeprazole and lafutidine on post-endoscopic submucosal dissection(ESD) gastric ulcers.METHODS:Patients with gastric tumors indicated for ESD were prospectively studied.After ESD,all patients were treated with intravenous omeprazole for the first 3 d.Patients were then randomly assigned to oral lafutidine or rabeprazole.Ulcer size,ulcer size reduction rate,and ulcer stage were evaluated 4 wk later.Occurrence of complication was monitored throughout the 4-wk period.RESULTS:Sixty five patients were enrolled in the study,and 60 patients were subjected to the final analysis.In the lafutidine group(30 lesions in 29 patients),initial and 4-wk post-ESD ulcer sizes were 33.3 ± 9.2 and 10.5 ± 4.8 mm,respectively.In the rabeprazole group(34 lesions in 31 patients),the values were 34.7 ± 11.3 and 11.8 ± 6.7 mm,respectively.Ulcer size reduction rates in lafutidine and rabeprazole groups were 32.3% and 33.5%,respectively(P=0.974).Ulcer stage 4 wk post-ESD did not differ significantly between the two groups(P=0.868).Two cases in the rabeprazole group and no cases in the lafutidine group developed ulcer bleeding during the oral dose period,although the difference of bleeding rate between the two groups was not statistically significant(P=0.157).CONCLUSION:Lafutidine and rabeprazole have equivalent therapeutic effects on post-ESD gastric ulcers. | Tomohiko Richard Ohya Hiroki Endo Kei Kawagoe Tatsuro Yanagawa Katsuhiro Hanawa Ken Ohata Masako Asayama Kantaro Hisatomi Takuma Teratani Toshiaki Gunji Hajime Sato Nobuyuki Matsuhashi | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，1： | 7 |
| 8 | Nature:单核细胞SatM导致组织纤维化显示文摘在一项新的研究中,来自日本大阪大学免疫学前沿研究中心(IFReC)的研究人员报道了一类新的他们称之为SatM的单核细胞。针对小鼠的研究表明SatNI可能是导致组织纤维化的原因,而且成为一种治疗很少有有效疗法的疾病的新药物靶标。 | Takashi Satoh, Katsuhiro Nakagawa, Fumihiro Yamane, Kiyoharu Fukushima, Isao Ebina Shizuo Akira Takashi Satoh, Katsuhiro Nakagawa, Fumihiro Yamane, Kiyoharu Fukushima, Isao Ebina Shizuo Akira Fuminori Sugihara Yoshichika Yoshioka Ryusuke Kuwahara Motooki Ashihara, Yosuke Minowa Isao Ebina Atsushi Kumanogoh Atsushi Kumanogoh | 2017 | 现代生物医学进展2017，17，3： | 7 |
| 9 | A novel synthesis method and up-conversion properties of hexagonal-phase NaYF_4:Er nano-crystals显示文摘A novel synthesis method for hexagonal(β)-phase NaYF4:Er nano-crystals(NCs)which showed up-conversion(UC)from infrared to visible spectral region was developed.The NaYF4:Er NCs were synthesized in oleic acid(OA)and 1-octadecene(ODE)with Y2(CO3)3· xH2O,Er2(CO3)3· xH2O,Na2CO3 and NH4F as precursors.This proposed method was simple and less toxic compared with generally used method so far.The XRD results showed that the molar ratio of OA/ODE and the temperature were key factors for phase control of NaYF4:Er NCs.The UC emission spectra were obtained with the emission wavelength at about 980 nm(4I11/2→4I15/2),800 nm(4I9/2→4I15/2),660 nm(4F9/2→4I15/2)and 540 nm(4S3/2→4I15/2)from Er3+ ions,by excitation wavelength of 1550 nm.The slope values,n,in the pump-power dependence,showed that the emission at 980 and 800 nm were generated by 2-step UC and at 660 nm and 540 nm were 3-step UC.The optical process for the UC excitation was discussed. | 罗显佳 Ryosuke Yuminami Takeaki Sakurai Katsuhiro Akimoto | 2013 | Journal of Rare Earths2013，31，3： | 4 |
| 10 | 多育赛多孢菌性鼻窦炎1例——致病菌的鉴定和体外抗真菌药物敏感性研究显示文摘目的报告国内首例多育赛多孢菌致鼻窦炎,并探讨致病菌的鉴定及其对抗真菌药物体外敏感性。方法取患者左侧上颌窦分泌物进行真菌培养和形态学鉴定,分离菌株β-球蛋白、rDNAITS序列分析确切鉴定,对分离菌进行7种抗真菌药体外药敏试验。结果根据菌株的形态学特点和基因序列结果鉴定为多育赛多孢菌。体外药敏试验显示该菌对7种抗真菌药物耐药。结论多育赛多孢菌所致的真菌病较少见,其确切鉴定靠形态学特征和基因分析。该菌株对多种抗真菌药物耐药。 | 帕丽达.阿布利孜 Takashi Yaguchi 罗德梅 惠艳 Katsuhiro Kamei Kazuko Nishimura | 2010 | 中国真菌学杂志2010，5，1： | 3 |
| 11 | Multi-center randomized controlled study to establish the standard third-line regimen for Helicobacter pylori eradication in Japan显示文摘 | Kazunari Murakami Takahisa Furuta Takashi Ando Takeshi Nakajima Yoshikatsu Inui Tadayuki Oshima Toshihiko Tomita Katsuhiro Mabe Makoto Sasaki Takanori Suganuma Hideyuki Nomura Kiichi Satoh Shinichiro Hori Syuuji Inoue Takeshi Tomokane Mineo Kudo Tomoki In | 2013 | Journal of Gastroenterology2013，，10： | 3 |
| 12 | PbMC1a/1b regulates lignification during stone cell development in pear(Pyrus bretschneideri)fruit显示文摘Programmed cell death(PCD)and secondary cell wall(SCW)thickening in pear fruit are accompanied by the deposition of cellulose and lignin to form stone cells.Metacaspase is an important protease for development,tissue renewal and PCD.The understanding of the molecular mechanism whereby pear(Pyrus)metacaspase promotes PCD and cell wall lignification is still limited.In this study,the Metacaspases gene family(PbMCs)from P.bretschneideri was identified.PbMC1a/1b was associated with lignin deposition and stone cell formation by physiological data,semiquantitative real-time polymerase chain reaction(RT-PCR)and quantitative RT-PCR(qRT-PCR).Relative to wildtype(WT)Arabidopsis,the overexpression of PbMC1a/1b increased lignin deposition and delayed growth,thickened the cell walls of vessels,xylary fibers and interfascicular fibers,and increased the expression of lignin biosynthetic genes.Yeast two-hybrid(Y2H),bimolecular fluorescence complementation(BiFC)and GST pull-down assays indicated that the PbMC1a/1b protein physically interacted with PbRD21.Simultaneously,the transient expression of PbMC1a/1b and PbRD21 led to significant changes in the expression of genes and lignin contents in pear fruits and flesh calli.These results indicate that PbMC1a/1b plays an important role in cell wall lignification,possibly by interacting with PbRD21 to increase the mRNA levels of some lignin synthesis-associated genes and promote the formation of stone cells in pear fruit. | Xin Gong Zhihua Xie Kaijie Qi Liangyi Zhao Yazhou Yuan Jiahui Xu Weikang Rui Katsuhiro Shiratake Jianping Bao Shahrokh Khanizadeh Shaoling Zhang Shutian Tao | 2020 | Horticulture Research2020，7，1： | 3 |
| 13 | A novel preoperative fusion analysis using three-dimensional MDCT combined with three-dimensional MRI for patients with hilar cholangiocarcinoma显示文摘 | Yukio Oshiro Ryoko Sasaki Katsuhiro Nasu Nobuhiro Ohkohchi | 2013 | Clinical Imaging2013，，4： | 2 |
| 14 | Pathological response measured using virtual microscopic slides for gastric cancer patients who underwent neoadjuvant chemotherapy显示文摘BACKGROUND Although pathological response is a common endpoint used to assess the efficacy of neoadjuvant chemotherapy (NAC) for gastric cancer, the problem of a low rate of concordance from evaluations among pathologists remains unresolved. Moreover, there is no globally accepted consensus regarding the optimal evaluation. A previous study based on a clinical trial suggested that pathological response measured using digitally captured virtual microscopic slides predicted patients’ survival well. However, the pathological concordance rate of this approach and its usefulness in clinical practice were unknown. AIM To investigate the prognostic utility of pathological response measured using digital microscopic slides in clinical practice. METHODS We retrospectively evaluated pathological specimens of gastric cancer patients who underwent NAC followed by surgery and achieved R0 resection between March 2009 and May 2015. Residual tumor area and primary tumor beds were measured in one captured image slide, which contained the largest diameter of the resected specimens. We classified patients with < 10% residual tumor relative to the primary tumorous area as responders, and the rest as non-responders;we then compared overall survival (OS) and relapse-free survival (RFS) between these two groups. Next, we compared the prognostic utility of this method using conventional Japanese criteria. RESULTS Fifty-four patients were evaluated. The concordance rate between two evaluators was 96.2%. Median RFS of 25 responders and 29 non-responders was not reached (NR) vs 18.2 mo [hazard ratio (HR)= 0.35, P = 0.023], and median OS was NR vs 40.7 mo (HR = 0.3, P = 0.016), respectively. This prognostic value was statistically significant even after adjustment for age, eastern cooperative oncology group performance status, macroscopic type, reason for NAC, and T- and Nclassification (HR = 0.23, P = 0.018). This result was also observed even in subgroup analyses for different macroscopic types (Borrmann type 4/non-type 4) and histological types (differentiated/undifferentiated). Moreover, the adjusted HR for OS between responders and non-responders was lower in this method than that in the conventional histological evaluation of Japanese Classification of Gastric Carcinoma criteria (0.23 vs 0.39, respectively). CONCLUSION The measurement of pathological response using digitally captured virtual microscopic slides may be useful in clinical practice. | Sadayuki Kawai Tadakazu Shimoda Takashi Nakajima Masanori Terashima Katsuhiro Omae Nozomu Machida Hirofumi Yasui | 2019 | World Journal of Gastroenterology2019，25，35： | 2 |
| 15 | Surgical treatment for a combined anterior cruciate ligament and posterior cruciate ligament avulsion fracture: A case report显示文摘BACKGROUND Independent avulsion fractures with anterior cruciate ligament(ACL)or posterior cruciate ligament(PCL)attachment are relatively common among tibial intercondylar eminence fractures,and their postoperative outcomes are generally favorable.Conversely,huge avulsion fractures of the intercondylar eminence containing the attachment site of both the ACL and the PCL are extremely rare,and the reported clinical outcomes are poor.CASE SUMMARY We describe a 30-year-old Japanese male's huge avulsion fracture of the intercondylar eminence of a tibia containing the attachment site of both the ACL and PCL,together with a complete tear of the medial collateral ligament and a partial tear of both the medial and lateral menisci caused by a fall from a high place.All of these injuries were treated surgically,with anatomical reduction and stable fixation.The limb function at 1 year post-surgery was excellent(Lysholm score:100 points).CONCLUSION Although this patient's complete surgical repair was complex,it should be performed in similar cases for an excellent final clinical outcome. | Katsuhiro Yoshida Michiyuki Hakozaki Hideo Kobayashi Masashi Kimura Shinichi Konno | 2022 | World Journal of Clinical Cases2022，10，12： | 2 |
| 16 | Submucosal hematoma 是一高度暗示的作出对 \O 有利的裁决淀粉的轻链的淀粉样变性病: 二份案例报告显示文摘 The clinical and endoscopic features of amyloid lightchain(AL) amyloidosis are diverse and mimic various other diseases.Endoscopically,few reports on submucosal hematomas of the gastrointestinal(GI) tract are available in the literature.Here,we report two cases of AL amyloidosis presenting as submucosal hematomas in the absence of clinical disease elsewhere in the body.The 2 cases were referred to our hospital because of hematochezia.The endoscopic findings in both cases were similar in submucosal hematoma formation.However,the clinical courses differed.In the first case,there was no evidence of systemic amyloidosis and the disease was conservatively managed.In the second case,the disease progressed to systemic amyloidosis and the patient died within a short time.We conclude that the endoscopic detection of a submucosal hematoma in the setting of GI bleeding should raise suspicion of AL amyloidosis.Referral to a hematologist should be done immediately for treatment while the involvement is limited to the GI tract. | Shinji Yoshii Katsuhiro Mabe Katsuhiko Nosho Hiroyuki Yamamoto Hiroshi Yasui Hiroyuki Okuda Akira Suzuki Masahiro Fujita Toshihiro Sato | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，9： | 2 |
| 17 | An interactive fuzzy satisficing method for multiobjective nonconvex programming problems with fuzzy numbers through coevolutionary genetic algorithms显示文摘 | Masatoshi Sakawa Katsuhiro Yauchi | 2001 | IEEE Transactions on Systems Man and Cybernetics-Part B2001，3，： | 2 |
| 18 | Preparation of dense cordierite ceramics from magnesium compounds and kaolinite without additives显示文摘 | YUICHI Kobayashi KATSUHIRO Sumi ETSURO Kato | 2000 | Ceram Int2000，26，： | 2 |
| 19 | Molecular pathology of gastric cancer: Research and practice显示文摘 | Wataru Yasui Kazuhiro Sentani Naoya Sakamoto Katsuhiro Anami Yutaka Naito Naohide Oue | 2011 | Pathology - Research and Practice2011，，10： | 2 |
| 20 | Crotalphine,a novel potent analgesic peptide from the venom of the south American rattlesnake Crotalus durissus terrificus显示文摘 | Katsuhiro K Gisele P Vanessa PG | 2008 | Peptides2008，29，8： | 1 |
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