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| 1 | Innate and adaptive immune responses in male and female reproductive tracts in homeostasis and following HIV infection显示文摘男、女的繁殖的道是有多样的功能的要求的复杂微型环境。当同时对潜在的病原体授与保护时,在繁殖的道的免疫系统举办为胎儿的 allograft 提供保护的环境的费力的任务。因此,它发展了改编的一个唯一的集合,首先在性荷尔蒙的影响下面,它从另外的 mucosal 地点使它不同。这里,我们讨论在男性和女繁殖的道是在场的免疫系统的各种各样的部件,包括在 homeostatic 条件下面的天生的可溶的因素和房间和体液、调停房间的适应免疫。我们考察在从全身的豁免展出区分并且讨论这些特征怎么被性荷尔蒙影响的男、女的繁殖的道显示出唯一的 phenotypic 和有免疫力的房间和回答的功能的特征的证据。我们也在跟随 HIV-1 感染的繁殖的道,性荷尔蒙和有免疫力的回答之中检验相互作用。男、女的繁殖的道的唯一的特征的改进理解将提供卓见进为性播送的感染的预防改进不孕的免疫学的原因和预防干预的设计的临床的处理。 | Philip V Nguyen Jessica K Kafka Victor H Ferreira Kristy Roth Charu Kaushic | 2014 | Cellular & Molecular Immunology2014，11，5： | 7 |
| 2 | Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier显示文摘More than 40%of HIV infections occur via female reproductive tract(FRT)through heterosexual transmission.Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens.These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses.Previously,we have shown that in response to HIV-1 gp120,the genital epithelial cells(GECs)from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection.In this study,we report that the endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to HIV-1 that act to protect the epithelial tight junction barrier.The innate antiviral response was directly induced by HIV-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inhibited IFNβproduction.Interferon-βwas induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.The induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).The IFNβwas biologically active,had a protective effect on epithelial tight junction barrier and was able to inhibit HIV-1 infection in TZM-bl indicator cells and HIV-1 replication in T cells.This is the first report that recognition of HIV-1 by upper GECs leads to induction of innate antiviral pathways.This could explain the overall low infectivity of HIV-1 in the FRT and could be exploited for HIV-1 prophylaxis. | Aisha Nazli Sara Dizzell Muhammad Atif Zahoor Victor H Ferreira Jessica Kafka Matthew William Woods Michel Ouellet Ali A Ashkar Michel J Tremblay Dawn ME Bowdish Charu Kaushic | 2019 | Cellular & Molecular Immunology2019，16，2： | 2 |
| 3 | Chlamydia trachomatis infection in the female reproductive tract of the rat: influence of progesterone on infectivity and immune response 显示文摘 | Kaushic C Murdin AD Underdown BJ | 1998 | Infect Immun1998，66，3： | 1 |
| 4 | Chlamydia trachomatis infection in the female reproductive tract of the rat: influence of progesterone on infectivity and immune response 显示文摘 | Kaushic C Murdin AD Underdown BJ | 1998 | Infect Immun1998，66，3： | 1 |
| 5 | HIV-1 gpl20 induces TLR2- and TLR4- mediated innate immune activation in human female genital epithelium显示文摘 | Nazli A Kafka J K Ferreira V H Anipindi V Muel- ler K Osborne B J Dizzell S Chauvin S Mian M F Ouellet M Tremblay M J Mossman K L Ashkar A A Kovacs C Bowdish D M Snider D P Kaul R Kaushic C | 2013 | J Immunol2013，191，8： | 1 |
| 6 | Antigen-presenting cells in the female reproductive tract:influence of estradiol on antigen presentation by vaginal cells显示文摘 | Rossoll R M Kaushic C | 2000 | Endocrinology2000，141，8： | 1 |
| 7 | Increased prevalence of sexually transmitted viral infections in women: The role of female sex hormones in regulating susceptibility and immune responses显示文摘 | Kaushic C Roth K L Anipindi V | 2011 | J Reprod Immunol2011，88，2： | 1 |
| 8 | Effects of estradiol and progesterone on susceptibility and early immune responses to Chlamydia trachomatis in fection in the female reproductive tract显示文摘 | Kaushic C Zhou F Murdin AD | 2000 | Infect Immun2000，68，7： | 1 |
| 9 | Antifertility Effects of Neem (Azadirachta indica) Oil by Single Intrauterine Administration: A Novel Method for Contraception显示文摘 | Shakti N. Upadhyay Charu Kaushic G. P. Talwar | 1990 | Proceedings of the Royal Society B: Biological Sciences1990，，1305： | 1 |
| 10 | Regulation of polymeric immunoglobulin A receptor messenger ribonucleic acid expressior in rodent uteri:effect of sex hormones显示文摘 | Richardson J M Wira C R | 1995 | Endocrinology1995，136，7： | 1 |
| 11 | Antigen-presen-ting cells in the female reproductive tract:Influence of estra-diol on antigen presentation by vaginal cells显示文摘 | WIRA C R ROSSOLL R M KAUSHIC C | 2000 | Endocrinolo-gy2000，141，8： | 1 |
| 12 | Mode of Long-Term Antifertility Effect of Intrauterine Neem Treatment (IUNT) 显示文摘 | KAUSHIC C UPADHYAY S | 1995 | Contraception1995，51，3： | 1 |
| 13 | Increased prevalence of sexually transmitted viral infections in women: the role of female sex hormones in regulating susceptibility and immune responses 显示文摘 | Kaushic C Roth K L Anipindi V | 2011 | J Reprod Immunol2011，88，2： | 1 |
| 14 | Effects of estradiol and progesterone on susceptibilitiy and early immune responses to Chlamydia trachomatis infection in the female reproductive tract显示文摘 | Kaushic C Zhou Fan Murdin AD | 2000 | Infect and Immunity2000，68，7： | 1 |
| 15 | Effects of estradiol and progester- one on susceptibility and early immune responses to Chlamydia trachom- atis infection in the female reproductive tract显示文摘 | Kaushic C Zhou F Murdin AD | 2000 | Infect Immun2000，68，7： | 1 |
| 16 | The role of the local microenvironment in regulating susceptibility and immune responses to sexually transmitted viruses in the female genital tract显示文摘 | Kaushic C | | 0，，1： | 1 |
| 17 | The role of the local microenvironment in regulating susceptibility and immune responses to sexually transmitted viruses in the female genital tract显示文摘 | Kaushic C | 2009 | J Reprod Immunol2009，83，12： | 1 |
| 18 | Influence of the es- trous cycle on the presence and distribution of immune cells in the rat reproductive tract 显示文摘 | Kaushic C Frauendorf E Rossoll RM | 1998 | Am J Reprod Immunol1998，39，： | 1 |
| 19 | Influence of Common Mucosal Co‐Factors on HIV Infection in the Female Genital Tract显示文摘 | Victor H. Ferreira Jessica K. Kafka Charu Kaushic | 2014 | Am J Reprod Immunol2014，，6： | 1 |
| 20 | Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation 显示文摘 | Nazli A Chan O Dobson-Belaire WN Ouellet M Tremblay MJ Gray-Owen SD Arsenault AL Kaushic C | 2010 | PLoS Pathog2010，6，10： | 1 |
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