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| 1 | Melatonin attenuates high fat diet-induced fatty liver disease in rats显示文摘AIM:To investigate melatonin's preventive action in oxidative stress in a rat model with high fat diet-induced non-alcoholic fatty liver disease(NAFLD).METHODS:NAFLD was induced by high fat diet(HFD)in adult,male,Wistar rats,weighing 180-230 g.After acclimatization for one week,they were randomly assigned to 6 experimental groups that comprised animals on regular diet plus 5 or 10 mg/kg melatonin,for 4 or 8 wk;animals on HFD,with or without 5 or 10 mg/kg melatonin,for 4 or 8 wk;and animals on HFD for 8 or 12 wk,with melatonin 10 mg/kg for the last 4 wk.Liver damage was assessed biochemically by the serum levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),and histologically.Lipid peroxidation and oxidative stress were assessed by malondialdehyde and glutathione levels in liver tissue.Lipidemic indices and portal vein pressure were also measured.RESULTS:Compared to rats not receiving melatonin,rats on 5 or 10 mg/kg of melatonin had lower mean liver weight(-5.0 g and-4.9 g)(P < 0.001)and lower liver weight to body weight ratio(-1.0%)(P < 0.001),for the two doses,respectively.All rats fed HFD without melatonin developed severe,grade Ⅲ,steatosis.Rats on HFD with concurrent use of melatonin showed significantly less steatosis,with grade Ⅲ steatosis observed in 1 of 29(3.4%)rats on 10 mg/kg melatonin and in 3 of 27(11.1%)rats on 5 mg/kg melatonin.Melatonin was ineffective in reversing established steatosis.Melatonin also had no effect on any of the common lipidemic serum markers,the levels of which did not differ significantly among the rats on HFD,irrespective of the use or not of melatonin.Liver cell necrosis was significantly less in rats on HFD receiving melatonin than in those not on melatonin,with the AST levels declining by a mean of 170 U/L(P = 0.01)and 224 U/L(P = 0.001),and the ALT levels declining by a mean of 62.9 U/L(P = 0.01)and 93.4 U/L(P < 0.001),for the 5 and 10 mg/kg melatonin dose,respectively.Melatonin mitigated liver damage due to peroxidation and oxidative stress in liver tissue as indicated by a significant decline in MDA production by 12.7(P < 0.001)and 12.2(P < 0.001)μmol/L/mg protein/mg tissue,and a significant increase in glutathione by 20.1(P = 0.004)and 29.2(P < 0.001)μmol/L/mg protein/mg tissue,for the 5 and 10 mg/kg melatonin dose,respectively.CONCLUSION:Melatonin can attenuate oxidative stress,lessen liver damage,and improve liver histology in rats with high fat diet-induced NAFLD,when given concurrently with the diet. | Gregorios Hatzis Panayiotis Ziakas Nikolaos Kavantzas Aggeliki Triantafyllou Panagiotis Sigalas Ioanna Andreadou Konstantinos Ioannidis Stamatios Chatzis Konstantinos Filis Alexandros Papalampros Fragiska Sigala | 2013 | World Journal of Hepatology2013，5，4： | 4 |
| 2 | Mitosin, a novel marker of cell proliferation and early recurrence in intracranial meningiomas 显示文摘 | Konstantinidou AE Korkolopoulou P Kavantzas N | 2003 | Histol Histopathol2003，18，1： | 1 |
| 3 | Computerized nuclear morphometry of renal cell carcinomas显示文摘 | Paraskevakou E Kavantzas N Pavlopoulos | 1996 | Gen Diagn Pathol1996，142，2： | 1 |
| 4 | Prognostic implications of microvessel morphometry in diffuse astrocytic neoplasms显示文摘 | Korkolopoulou P Patsouris E Kavantzas N | 2002 | Neuropathol Appl Neurobiol2002，28，1： | 1 |
| 5 | Increased vein wall apoptosis in varicose vein disease is related to venous hypertension显示文摘 | Filis K Kavantzas N Isopoulos T | | 0，，4： | 1 |
| 6 | Increased vein wall apoptosis in varicose vein disease is related to venous hypertension显示文摘 | Filis K Kavantzas N Isopoulos T | 2011 | Eur J Vasc Endovasc Surg2011，41，4： | 1 |
| 7 | Neu- roendocrine differentiation in follicle-cell thyroid carcino- ma:correlation to prognostic factors in papillary carcinoma 显示文摘 | Tseleni-Balafouta S Kavantzas N Alevizaki M | 1998 | J Exp Clin Cancer Res1998，17，4： | 1 |
| 8 | A study of the pathogenesis of Rosacea: how angio- genesis and mast cells may participate in a complex muhifactorial process 显示文摘 | Aroni K Tsagroni E Kavantzas N | 2008 | Arch Dermatol Res2008，300，3： | 1 |
| 9 | Increased vein wall apop- tosis in varicose vein disease is related to venous hypertension显示文摘 | Filis K Kavantzas N Isopoulos T | 2011 | Eur J Vasc Endovasc Surg2011，41，4： | 1 |
| 10 | DNA topoisomerase Ⅱ-alpha immunoreactivity as a marker of tumor aggressiveness in invasive breast cancer显示文摘 | Lazaris AC Kavantzas N | 2000 | Pathobiology2000，68，3： | 1 |
| 11 | Prognostic implications of microvessel morphometry in diffuse astrocytic neoplasms显示文摘 | Korkolopoulou P Patsouris E Kavantzas N | 2002 | Neuropathol Appl Neurobiol2002，28，1： | 1 |
| 12 | Evaluation of apoptosis in varicose vein disease complicated by superficial vein thrombosis显示文摘 | Fills K Kavantzas N Dalainas I | 2014 | Vasa2014，43，4： | 1 |
| 13 | Markers of drug resistance in re-lapsing colon cancer显示文摘 | Kavantzas NG Zorzos HS | 2002 | Cancer Res Clin Oncol2002，128，2： | 1 |
| 14 | Computerized morpho-metric study on fine needle aspirates of cellular follicular lesions of the thyroid显示文摘 | Tseleni-Balafouta S Kavantza SVN C Paraskevakou H | 2000 | Anal Quant Cytol Histol2000，22，4： | 1 |
| 15 | Comparative study of angiogenesis in thyroid glands with Grave' s disease and Hashimoto's thymiditis显示文摘 | Teleni-Balafouta S Kavantzas N Balafoutas D | 2006 | Appl Immunohistochem Mol Morphol2006，14，2： | 1 |
| 16 | A morphometric study of the structural characteristics of the aorta in pigs using an image analysis method显示文摘 | Sokolis DP Boudoulas H Kavantzas NG | 2002 | Anat Histol Embryol2002，31，： | 1 |
| 17 | Prognostic implications of microvessel morphometry in diffuse astroeytic ne- oplasms显示文摘 | Korkolopoulou P Patsouris E Kavantzas N | 2002 | Neuropathol Appl Neurobiol2002，28，1： | 1 |
| 18 | Prognostic implications of microvessel morphometry in diffuse astrocytic neoplasms显示文摘 | Korkolopoulou P Patsouris E Kavantzas N | 2002 | Neuropathol Appl Neurobiol2002，28，1： | 1 |
| 19 | Prognostic implications of microvessel morphometry in diffuse astrocytic neoplasms显示文摘 | Korkolopoulou P Patsouris E Kavantzas N | 2002 | Neuropathol Appl Neurobiol2002，28，4： | 1 |
| 20 | DNA topoisomerase Ⅱ-alpha immunoreactivity as a marker of rumor aggressiveness in invasive breastcancer显示文摘 | Lazaris AC Kavantzas N | 2000 | Pathobiology2000，68，3： | 1 |
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