|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of in vitro interferon-beta administration on hepatitis C virus in peripheral blood mononuclear cells as a predictive marker of clinical response to interferon treatment for chronic hepatitis C显示文摘AIM:To test whether in vitro incubation of peripheral blood mononuclear cells (PBMC) with interferon (IFN) could efficiently decrease hepatitis C virus-RNA (HCV-RNA) amount and to analyze whether this effect was associated with clinical response to IFN.METHODS:Twenty-seven patients with histologically proven chronic hepatitis C were given intravenous administration of 6 million units (MU) IFN-β daily for 6 weeks followed by three times weekly for 20 weeks. PBMC collected before IFN therapy were incubated with IFN-β and HCV-RNA in PMBC was semi-quantitatively determined.RESULTS: Twenty-five patients completed IFN therapy.Eight patients (32%) had sustained loss of serum HCV-RNA with normal serum ALT levels after IFN therapy (complete responders).HCV-RNA in PBMC was detected in all patients,whereas it was not detected in PBMC from healthy subjects.In vitro administration of IFN-β decreased the amount of HCV-RNA in PMBC in 18 patients (72%). Eight of these patients obtained complete response. On the other hand,none of the patients whose HCV-RNA in PBMC did not decrease by IFN-β was complete responders. Multiple logistic regression analysis revealed that the decrease of HCV-RNA amount in PBMC by IFN-β was the only independent predictor for complete response (P<0.05).CONCLUSION:The effect of in vitro IFN-β on HCV in PBMC reflects clinical response and would be taken into account as a predictive marker of IFN therapy for chronic hepatitis C. | Kaori Mochizuki Tatehiro Kagawa Shinji Takashimizu Kazuya Kawazoe Sei-Ichiro Kojima Naruhiko Nagata Atsushi Nakano Yasuhiro Nishizaki Koichi Shiraishi Masaru Itakura Norihito Watanabe Tetsuya Mine Shohei Matsuzaki | 2004 | World Journal of Gastroenterology2004，10，5： | 12 |
| 2 | Fatal liver failure due to reactivation of lamivudine-resistant HBV mutant显示文摘We report a case of fatal liver failure due to reactivation of lamivudine-resistant HBV. A 53-year-old man was followed since 1998 for HBV-related chronic hepatitis. Serum HBV-DNA was 150 MEq/mL (branched DNA signal amplification assay) and ALT levels fluctuated between 50-200 IU/L with no clinical signs of liver cirrhosis. Lamivudine (100 mg/d) was started in May 2001 and serum HBV-DNA subsequently decreased below undetectable levels. In May 2002, serum HBV-DNA had increased to 410 MEq/mL, along with ALT flare (226 IU/L). The YMDD motif in the DNA polymerase gene had been replaced by YIDD. Lamivudine was continued and ALT spontaneously decreased to the former levels. On Oct 3 the patient presenting with general fatigue, nausea and jaundice was admitted to our hospital. The laboratory data revealed HBV reactivation and liver failure (ALT: 1828 IU/L, total bilirubin: 10 mg/dL, and prothrombin INR: 3.24). For religious reasons, the patient and his family refused blood transfusion, plasma exchange and liver transplantation. The patient died 10 d after admission. The autopsy revealed remarkable liver atrophy. | Tatehiro Kagawa Norihito Watanabe Hisashi Kanouda Ichiro Takayama Tadahiko Shiba Takashi Kanai Kazuya Kawazoe Shinji Takashimizu Nobue Kumaki Kazuo Shimamura Shohei Matsuzaki Tetsuya Mine | 2004 | World Journal of Gastroenterology2004，10，11： | 10 |
| 3 | Body mass index is associated with age-at-onset of HCV-infected hepatocellular carcinoma patients显示文摘AIM: To identify factors associated with the age at onset of hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC). METHODS: Five hundred and fifty-six consecutive patients positive for HCV antibody and treatment-nafive HCC diagnosed between 1995 and 2004 were analyzed. Patients were classified into three groups according to age at HCC onset: < 60 years (n = 79), 60-79 years (n = 439), or ≥ 80 years (n = 38). Differences among groups in terms of sex, body mass index (BMI), lifestyle characteristics, and liver function were assessed. Factors associated with HCC onset in patients < 60 or ≥ 80 years were analyzed by logistic regression analysis. RESULTS: Significant differences emerged for sex, BMI, degree of smoking and alcohol consumption, mean bilirubin, alanine aminotransferase (ALT), and γ-glutamyl transpeptidase (GGT) levels, prothrombin activity, and platelet counts. The mean BMI values of male patients > 60 years old were lower and mean BMI values of female patients < 60 years old were higher than those of the general Japanese population. BMI > 25 kg/m2 [hazard ratio (HR), 1.8, P = 0.045], excessive alcohol consumption (HR, 2.5, P = 0.024), male sex (HR, 3.6, P = 0.002), and GGT levels > 50 IU/L (HR, 2.4, P = 0.014) were independently associated with HCC onset in patients < 60 years. Low ALT level was the only factor associated with HCC onset in patients aged ≥ 80 years. CONCLUSION: Increased BMI is associated with increased risk for early HCC development in HCV-infected patients. Achieving recommended BMI and reducing alcohol intake could help prevent hepatic carcinogenesis. | Takumi Akiyama Toshihiko Mizuta Seiji Kawazoe Yuichiro Eguchi Yasunori Kawaguchi Hirokazu Takahashi Iwata Ozaki Kazuma Fujimoto | 2011 | World Journal of Gastroenterology2011，17，7： | 6 |
| 4 | Comparison between bioartificial and artificial liver for the treatment of acute liver failure in pigs显示文摘AIM: To characterize and evaluate the therapeuti efficacy of bioartificial liver (BAL) as compared to tha of continuous hemodiafiltration (CHDF) with plasma exchange (PE), which is the current standard therapy fo fulminant hepatic failure (FHF) in Japan. METHODS: Pigs with hepatic devascularization were divided into three groups: (1) a non-treatment group (NT; n = 4); (2) a BAL treatment group (BAL; n = 4) (3) a PE + CHDF treatment group using 1.5 L of norma porcine plasma with CHDF (PE + CHDF, n = 4). Our BA system consisted of a hollow fiber module with 0.2 μm pores and 1 x 1010 of microcarrier-attached hepatocyte inoculated into the extra-fiber space. Each treatment wa initiated 4 h after hepatic devascularization. RESULTS: The pigs in the BAL and the PE + CHD groups survived longer than those in the NT group. The elimination capacity of blood ammonia by both BAL and PE + CHDF was significantly higher than that in NT Aromatic amino acids (AAA) were selectively eliminated by BAL, whereas both AAA and branched chain amino acids, which are beneficial for life, were eliminated by PE + CHDF. Electrolytes maintenance and acid-base balance were better in the CPE + CHDF group than that in the BAL group. CONCLUSION: Our results suggest that PE + CHDF eliminate all factors regardless of benefits, wherea BAL selectively metabolizes toxic factors such as AAA However since PE + CHDF maintain electrolytes and acid-base balance, a combination therapy of BAL plu CPE + CHDF might be more effective for FHF. | Yasushi Kawazoe Susumu Eguchi Nozomu Sugiyama Yukio Kamohara Hikaru Fujioka Takashi Kanematsu | 2006 | World Journal of Gastroenterology2006，12，46： | 5 |
| 5 | Low-dose rectal diclofenac for prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a randomized controlled trial显示文摘 | Taiga Otsuka Seiji Kawazoe Shunya Nakashita Saori Kamachi Satoshi Oeda Chinatsu Sumida Takumi Akiyama Keisuke Ario Masaru Fujimoto Masanobu Tabuchi Takahiro Noda | 2012 | Journal of Gastroenterology2012，，8： | 4 |
| 6 | Ligand density-dependent influence of arginine-glycine- aspartate functionalized gold nanoparticles on osteogenic and adipogenic differentiation of mesenchymal stem cells显示文摘细胞外的矩阵(ECM ) 在调整房间功能和命运起一个很重要的作用。制作 biomimetic 模型在干细胞区别调查 ECM 的角色是高度合乎需要的。在这研究, arginine-glycine-aspartate (RGD ) 与悦耳的表面 ligand 修改了金 nanoparticles (Au NP ) 密度被准备模仿 ECM 微型环境。他们 osteogenic 和人的间充质的干细胞(MSC ) 的 adipogenic 区别上的效果被调查。biomimetic Au NP 被 MSC 以一种 ligand 密度依赖者方式收起。有高 RGD 密度的 biomimetic NP 在碱的磷酸酶(高山) 上有禁止的效果活动,钙免职,和 MSC 的 osteogenic 标记基因表示。当 RGD 密度是低的时,当 RGD 密度高时,他们油微滴形成和 adipogenic 标记基因表示上的效果是否定的,当他们的效果是提升的时。biomimetic Au NP 主要通过影响焦点的粘附和细胞骨架调整了 MSC 的 osteogenic 和 adipogenic 区别。这研究在能在为织物工程和生物医学的应用制作功能的 biomaterials 提供有意义的策略的干细胞区别上加亮 biomimetic NP 的角色。 | Jingchao Li Ying Chen Naoki Kawazoe Guoping Chen | 2018 | Nano Research2018，11，3： | 4 |
| 7 | Introduction of Japanese Society of Oral Implantology显示文摘In response to the significant advancement of oral implantology around the world,the Japanese Society of Oral Implantology(JSOI)was established in 1972.Its purpose is to promote and improve oral implantology in Japan,and introduce safe and predictable implant treatment methods. | Takayoshi Kawazoe | 2009 | International Journal of Oral Science2009，1，1： | 3 |
| 8 | Helianthus tuberosus(Jerusalem artichoke) tubers improve glucose tolerance and hepatic lipid profile in rats fed a high-fat diet显示文摘Objective:To analyze the effects of feeding Helianthus tuberosus(HT) tubers on glucose tolerance and lipid profile in rats fed a high-fat diet(HFD). Methods:A normal HFD or HFD including 10 w/w% HT tubers(HFD + HT) was fed to F334/Jcl rats. After 10 weeks,organ weights,glucose tolerance,and lipid profile were analyzed. Results:The body weight,liver weight,and epidermal fat content in the HFD group were higher than those of the normal group,and similar to those of the HFD + HT group. The oral glucose tolerance test at 10 weeks revealed that the blood glucose level 30 minutes after beginning the test in the HFD + HT group was significantly lower than that in the HFD group. Liver triglyceride and total cholesterol levels in the HFD + HT group were significantly lower than those in the HFD group. Fecal triglyceride and total cholesterol levels in the HFD + HT group were higher than those in the HFD group. Histological analyses revealed that fat and glycogen accumulation increased in the HFD group,but decreased in the HFD + HT group. Conclusions:These results indicate that HT tubers have anti-fatty liver effects based on improvements in glucose tolerance and the hepatic lipid profile. | Naoto Okada Shinya Kobayashi Kouta Moriyama Kohsuke Miyataka Shinji Abe ChiemiSato Kazuyoshi Kawazoe | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，5： | 2 |
| 9 | Technical Development of Simple Shear Deformation Experiments Using a Deformation-DIA Apparatus显示文摘Technical developments for simple shear deformation experiments at high pressures were made. The newly designed cell assembly can be compressed by deformation-DIA apparatuses with the MA 6-6 system, which consists of six second-stage tungsten carbide anvils (with a truncated edge length of 5 mm) and the anvil guide. Deformation of samples was barely observed during the compression process, showing that the shear strain of the deformed samples can be measured by the rotation of a strain marker. Simple shear deformation experiments on anhydrous and hydrous oli-vine aggregates were conducted under upper mantle conditions (pressures of 5.2–7.6 GPa and tem-peratures of 1 473–1 573 K), and sample deformation with a shear strain of γ=0.8–1.2 was success-fully achieved at a shear strain rate of 4.0×10-5–7.5×10-5 s-1. The present study extended the pressure range of simple shear deformation experiments in the deformation-DIA apparatus from 3 GPa in an early study to 7.6 GPa at high temperatures. | Tomohiro Ohuchi Takaaki Kawazoe Norimasa Nishiyama Yu Nishihara Tetsuo Irifune | 2010 | Journal of Earth Science2010，21，5： | 2 |
| 10 | Concentrations and compositions of organochlorine contaminants in sediments, soils, crustaceans, fishes and birds collected from Lake Tai, Hangzhou Bay and Shanghai city region, China显示文摘 | Haruhiko Nakata Yuko Hirakawa Masahiro Kawazoe Tetsuji Nakabo Koji Arizono Shin-Ichi Abe Takeshi Kitano Hideaki Shimada Izumi Watanabe Weihua Li Xucheng Ding | 2004 | Environmental Pollution2004，，3： | 2 |
| 11 | Exohedral functionalization of the icosahedral cluster Si20 H20:a density functional theory study 显示文摘 | Pichierr F Kumar V Kawazoe Y | 2004 | Chem Phys Lett2004，383，： | 1 |
| 12 | Effects of recombinant human hepatocyte growth factor on the proliferation and function of porcine hepatocytes显示文摘 | Eguchi S Kawazoe Y Sugiyama N | 2000 | ASAIO J2000，46，： | 1 |
| 13 | P-type electrical conduction in transparent thin films of CuAlO2显示文摘 | Kawazoe H Yasukawa M Hyodo H | 1997 | Nature1997，，389： | 1 |
| 14 | p-Type Electrical Conduction in Transparent Thin Films of Cu Al O2显示文摘 | Kawazoe H Yasukawa M Hyodo H | 1997 | Nature1997，389，： | 1 |
| 15 | The effect of segregation and partial order on the thermodynamics of (1<ce:hsp sp='0.25'/>1<ce:hsp sp='0.25'/>1) antiphase boundaries in Ni 3 Al显示文摘 | Marcel Sluiter Y. Hashi Yoshiyuki Kawazoe | 1999 | Computational Materials Science1999，，1： | 1 |
| 16 | Prolonged anti-infl ammatory action of D, L-lactide/glycolide copolymer nanosph eres containing betamethasone sodium phosphate for an intra articular delivery system in antigen-induced arthritic rabbit显示文摘 | Horisawa E Hirota T Kawazoe S | 2002 | Pharm Res2002，19，： | 1 |
| 17 | The nitration of quinoline and quinoline-1-oxide 显示文摘 | Kawazoe Y Tachibana M | 1967 | Chem Pharm Bull1967，15，： | 1 |
| 18 | Direct coupling of microcolumn liquid chromatography with in-tube solid-phase mieroextraction for the analysis of antidepressant drugs显示文摘 | Saito Y Kawazoe M Hayashida M | 2000 | Analyst2000，125，： | 1 |
| 19 | Indoor localization system using RSSI measurement of wireless sensor network based on ZigBee standard显示文摘 | Sugano M Kawazoe T | 2006 | IASTED International Conference Banff2006，25，17： | 1 |
| 20 | Comparison of chemically induced DNA breakage in cellular and subcellular systems using the comet assay显示文摘 | Kasamatsu T Kohda K Kawazoe Y | 1996 | Mutat Res1996，369，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员