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| 1 | Role of functional imaging in the development and refinement of invasive neuromodulation for psychiatric disorders显示文摘Deep brain stimulation(DBS) is emerging as a pow-erful tool for the alleviation of targeted symptoms in treatment-resistant neuropsychiatric disorders. Despite the expanding use of neuropsychiatric DBS, the mecha-nisms responsible for its effects are only starting to be elucidated. Several modalities such as quantitative elec-troencephalography as well a intraoperative recordings have been utilized to attempt to understand the under-pinnings of this new treatment modality, but functional imaging appears to offer several unique advantages. Functional imaging techniques like positron emission tomography, single photon emission computed tomog-raphy and functional magnetic resonance imaging have been used to examine the effects of focal DBS on activ-ity in a distributed neural network. These investigations are critical for advancing the field of invasive neuro-modulation in a safe and effective manner, particularly in terms of defining the neuroanatomical targets and refining the stimulation protocols. The purpose of this review is to summarize the current functional neuroim-aging findings from neuropsychiatric DBS implantation for three disorders: treatment-resistant depression, obsessive-compulsive disorder, and Tourette syndrome. All of the major targets will be discussed(Nucleus ac-cumbens, anterior limb of internal capsule, subcallosal cingulate, Subthalamic nucleus, Centromedial nucleus of the thalamus-Parafasicular complex, frontal pole, and dorsolateral prefrontal cortex). We will also address some apparent inconsistencies within this literature, and suggest potential future directions for this promis-ing area. | Nolan R Williams Joseph J Taylor Kayla Lamb Colleen A Hanlon E Baron Short Mark S George | 2014 | World Journal of Radiology2014，6，10： | 6 |
| 2 | Development and deployment of an intemet based data management system for use by the Asthma Clinical Research Network显示文摘 | Curley RM Evam RL Kayla J | 2003 | Control Clint Trials2003，22，： | 1 |
| 3 | Identification of dual α4β1 integrin binding sites within a 38 amino acid domain in the N-terminal thrombin fragment of human osteopontin显示文摘 | Kayla J B George E D | 2001 | JBiolChem2001，276，13： | 1 |
| 4 | Evidence for a critical role of gene occlusion in cell fate restriction显示文摘尽管有它的普遍存在,细胞命运的进步限制在系区别期间是糟糕理解的现象。我们最近使用了房间熔化试金定义我们称为的 epigenetic silencing 的一个模式 “ occlusion”,不管交易的 transcriptional 使活跃之物是否是在场的,在那里影响了基因,是由行动 cis 染色质机制的 silenced。我们假设了系不恰当的基因的那吸藏能贡献房间命运限制。这里,我们由介绍细菌的人工的染色体(用绳子拖的平底渡船) 测试这个假设,它缺乏为吸藏必要的染色质修正,进老鼠成纤维细胞。我们发现相应于堵塞内长的基因的用绳子拖的平底渡船 transgenes 在大多数情况中被表示,而相应于沉默却非堵塞的内长的基因的用绳子拖的平底渡船 transgenes 没被表示。这显示在 trans 的细胞的周围在成纤维细胞支持大多数堵塞基因的表示,并且这些基因的沉默状态是完全在 cis 的吸藏的后果。为相应于堵塞 myogenic 主人管理者 Myf5 的 BAC, BAC 上的 Myf5 transgene 的表示触发了成纤维细胞获得像肌肉的显型。这些结果在房间命运限制为基因吸藏的一个关键角色提供引人注目的证据。 | Jedidiah Gaetz Kayla L Clift Croydon J Femandes Frank Fuxiang Mao Jae Hyun Lee Li Zhang Samuel W Baker Timothy J Looney Kara M Foshay Wei-Hua Yu Andy Peng Xiang Bruce T Lahn | 2012 | Cell Research2012，22，5： | 1 |
| 5 | 去甲肾上腺素激活星形胶质细胞内核膜上的β1-肾上腺素能受体显示文摘去甲肾上腺素对星形胶质细胞的代谢、神经保护和免疫调节功能有强大的影响。直到最近,去甲肾上腺素的所有作用尚被认为是由仅存在于细胞质膜的受体介导的。然而,最近对心肌细胞的研究已经确定定位于细胞内膜(包括高尔基体和内核膜)的肾上腺素能受体,并表明去甲肾上腺素可以通过转运蛋白介导的摄取而作用于这些受体。我们最近发现了一种高容量去甲肾上腺素转运蛋白有机阳离子转运蛋白3(OCT3)。该转运蛋白密集定位于星形胶质细胞的外核膜,这表明肾上腺素能信号传导也可能发生在这些细胞的内核膜上。本研究证实:使用免疫荧光和蛋白质印迹技术显示β1-肾上腺素受体定位于星形胶质细胞内核膜;关键的肾上腺素能信号通路组分存在于星形胶质细胞核中;且OCT3和其他儿茶酚胺转运蛋白于星形胶质细胞质膜和核膜均表达。为了测试核膜β1-肾上腺素能受体的功能,我们使用荧光生物传感器实时监测星形胶质细胞核中的蛋白激酶A(PKA)活性。用去甲肾上腺素处理星形胶质细胞会导致核区室中PKA活性的快速增加。用儿茶酚胺摄取抑制剂预处理星形胶质细胞可阻断去甲肾上腺素诱导的核PKA活性的快速增加。这些研究首次记录了任何中枢神经系统细胞核膜上的功能性肾上腺素能受体,揭示了去甲肾上腺素可能直接影响核过程的新机制。这种机制可能与先前描述的去甲肾上腺素的神经保护、代谢和免疫调节作用有关。 | Kelsey C Benton Daniel S Wheeler Beliz Kurtoglu Mahshid Bagher Zadeh Ansari Daniel P Cibich Dante A Gonzalez Matthew R Herbst Saema Khursheed Rachel C Knorr Doug Lobner Jenree G Maglasang Kayla E Rohr Analisa Taylor Robert C Twining Paul JWitt Paul J Gasser 杜一星(编译) | 2022 | 神经损伤与功能重建2022，17，7： | 0 |
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