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| 1 | Lymphomatous involvement of gastrointestinal tract: Evaluation by positron emission tomography with ^(18)F-fluorodeoxyglucose显示文摘AIM: To demonstrate the 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) findings in patients with non-Hodgkin's lymphoma (NHL) involving the gastrointestinal (GI) tract and the clinical utility of modality despite of the known normal uptake of FDG in the GI tract.METHODS: Thirty-three patients with biopsy-proven gastrointestinal NHL who had undergone FDG-PET scan were included. All the patients were injected with 10-15 mCi FDG and scanned approximately 60 min later with a CTI/Siemens HR (+) PET scanner. PET scans were reviewed and the maximum standard uptake value (SUVmax) of the lesions was measured before and after the treatment,if data were available and compared with histologic diagnoses.RESULTS: Twenty-five patients had a high-grade lymphoma and eight had a low-grade lymphoma. The stomach was the most common site of the involvement (20 patients). In high-grade lymphoma, PET showed focal nodular or diffuse hypermetabolic activity. The average SUVmax±SD was 11.58±5.83. After the therapy,the patients whose biopsies showed no evidence of lymphoma had a lower uptake without focal lesions.The SUVmax±SD decreased from 11.58±5.83 to 2.21±0.78. In patients whose post-treatment biopsies showed lymphoma, the SUVmax±SD was 9.42±6.27. Low-grade follicular lymphomas of the colon and stomach showed diffuse hypermetabolic activity in the bowel wall (SUVmax 8.2 and 10.3, respectively). The SUVmax was 2.02-3.8 (mean 3.02) in the stomach lesions of patients with MALT lymphoma.CONCLUSION: 18F-FDG PET contributes to the diagnosis of high-grade gastrointestinal non-Hodgkin's lymphoma,even when there is the normal background FDG activity. Furthermore, the SUV plays a role in evaluating treatment response. Low-grade NHL demonstrates FDG uptake but at a lesser intensity than seen in high-grade NHL. | Sith Phongkitkarun Vithya Varavithya Toshiki Kazama Silvana C Faria Martha V Mar Donald A Podoloff Homer A Macapinlac | 2005 | World Journal of Gastroenterology2005，11，46： | 6 |
| 2 | Nomograms for colorectal cancer:A systematic review显示文摘AIM: To assist in the selection of suitable nomograms for obtaining desired predictions in daily clinicalpractice.METHODS: We conducted electronic searches for journal articles on colorectal cancer(CRC)-associated nomograms using the search terms colon/rectal/colorectal/nomogram. Of 174 articles initially found, we retrieved 28 studies in which a nomogram for CRC was developed.RESULTS: We discuss the currently available CRCassociated nomograms, including those that predict the oncological prognosis, the short-term outcome of treatments, such as surgery or neoadjuvant chemoradiotherapy, and the future development of CRC. Developing nomograms always presents a dilemma. On the one hand, the desire to cover as wide a patient range as possible tends to produce nomograms that are too complex and yet have C-indexes that are not sufficiently high. Conversely, confining the target patients might impair the clinical applicability of constructed nomograms.CONCLUSION: The information provided in this review should be of use in selecting a nomogram suitable for obtaining desired predictions in daily clinical practice. | Kazushige Kawai Eiji Sunami Hironori Yamaguchi Soichiro Ishihara Shinsuke Kazama Hiroaki Nozawa Keisuke Hata Tomomichi Kiyomatsu Junichiro Tanaka Toshiaki Tanaka Takeshi Nishikawa Joji Kitayama Toshiaki Watanabe | 2015 | World Journal of Gastroenterology2015，21，41： | 5 |
| 3 | Confirmation of Novel Quantitative Trait Loci for Seed Dormancy at Different Ripening Stages in Rice显示文摘Seed dormancy contributes resistance to pre-harvest sprouting.Effects on respective quantitative trait loci (QTLs) for dormancy should be assessed by using fresh seeds before germinability altered through storage.We investigated QTLs related to seed dormancy using backcross inbred lines derived from a cross between Nipponbare and Kasalath.Four putative QTLs for seed dormancy were detected immediately after harvest using composite interval mapping.These putative QTLs were mapped near C1488 on chromosome 3 (qSD-3.1),R2171 on chromosome 6 (qSD-6.1),R1245 on chromosome 7 (qSD-7.1) and C488 on chromosome 10 (qSD-10.1).Kasalath alleles promoted dormancy for qSD-3.1,qSD-6.1 and qSD-7.1,and the respective proportions of phenotypic variation explained by each QTL were 12.9%,9.3% and 8.1%.We evaluated the seed dormancy harvested at different ripening stages during seed development using chromosome segment substitution lines (CSSLs) to confirm gene effects.The germination rates of CSSL27 and CSSL28 substituted with the region including qSD-6.1 were significantly lower than those of Nipponbare and other CSSLs at the late ripening stage.Therefore,qSD-6.1 is considered the most effective novel QTL for pre-harvest sprouting resistance among the QTLs detected in this study. | Kazuhiro SASAKI Yuri KAZAMA Youn CHAE Tadashi SATO | 2013 | Rice science2013，20，3： | 4 |
| 4 | Breakthrough therapy for peritoneal carcinomatosis of gastric cancer:Intraperitoneal chemotherapy with taxanes显示文摘The effect of chemotherapy on peritoneal carcinomatosis(PC) of gastric cancer remains unclear.Recently,the intraperitoneal(IP) administration of taxanes [e.g.,paclitaxel(PTX) and docetaxel(DOC)] during the perioperative period has shown promising results.Herein,we summarized the rationale and methodology for using IP chemotherapy with taxanes and reviewed the clinical results.IP administered taxanes remain in the IP space at an extremely high concentration for 48-72 h.The drug directly infiltrates peritoneal metastatic nodules from the surface and then produces antitumor effects,making it ideal for IP chemotherapy.There are two types of perioperative IP chemotherapy with taxanes: neoadjuvant intraperitoneal and systemic chemotherapy and sequential perioperative intraperitoneal chemotherapy(SPIC).In SPIC,patients receive neoadjuvant IP chemotherapy and the same regimen of IP chemotherapy after cytoreductive surgery(CRS) until disease progression.Usually,a taxane dissolved in 500-1000 m L of saline at ordinary temperature is administered through an IP access port on an outpatient basis.According to phase Ⅰ?studies,the recommended doses(RD) are as follows: IP DOC,45-60 mg/m2; IP PTX [without intravenous(IV) PTX],80 mg/m2; and IP PTX(with IV PTX),20 mg/m2.Phase Ⅱ studies have reported a median survival time of 14.4-24.6 mo with a 1-year overall survival of 67%-78%.A phase Ⅲ study comparing S-1 in combination with IP and IV PTX to S-1 with IV cisplatin started in 2011.The prognosis of patients who underwent CRS was better than that of those who did not; however,this was partly due to selection bias.Although several phase Ⅱ studies have shown promising results,a randomized controlled study is needed to validate the effectiveness of IP chemotherapy with taxanes for PC of gastric cancer. | Hironori Yamaguchi Joji Kitayama Hironori Ishigami Shinsuke Kazama Hiroaki Nozawa Kazushige Kawai Keisuke Hata Tomomichi Kiyomatsu Toshiaki Tanaka Junichiro Tanaka Takeshi Nishikawa Kensuke Otani Koji Yasuda Soichiro Ishihara Eiji Sunami Toshiaki Watanabe | 2015 | World Journal of Gastrointestinal Oncology2015，7，11： | 3 |
| 5 | Microstructure of shear bands and its relation to the mechanisms of dilatancy and failure of dense granular soils显示文摘 | Oda M Kazama H | 1998 | Géotechnique1998，48，4： | 2 |
| 6 | A fate model of pathogenic viruses in a composting toilet based on coliphage inactivation显示文摘A composting toilet using sawdust as a matrix has the potential to trap pathogens that might occasionally be contained in human feces. Therefore, care should be taken when handling the sawdust. It should also be noted that pathogenic viruses tend to have stronger tolerance than pathogenic bacteria. The fates of several species of coliphages, T4, λ, Qβ and MS2, in sawdust were investigated as a viral model. The fates of coliphages were significantly different among them, and they changed in response to temperature and the water content of the sawdust. As the results, T4 coliphage had the strongest tolerance and Qβ had the weakest one in sawdust. It was estimated the days required to decrease virus to a safe level based on a risk assessment. According to the rates of Qβ and T4, 15 days and 167 days were required respectively for a safe level of infection risk based on actually operated composting toilet condition. Thus, it was significantly different depending on the species and sawdust conditions. | Shinobu Kazama Narue Tameike Naoko Nakagawa Masahiro Otaki | 2011 | Journal of Environmental Sciences2011，23，7： | 2 |
| 7 | Assessment of surface water quality using multivariate statistical techniques: A case study of the Fuji river basin, Japan显示文摘 | S. Shrestha F. Kazama | 2006 | Environmental Modelling and Software2006，，4： | 2 |
| 8 | Expression pattern of CXC ehemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma显示文摘 | Kato M Kitayama J Kazama S | 2003 | Breast Cancer Res2003，5，5： | 1 |
| 9 | Poorly differentiated colorectal adenocarcinomas show higher rates of microsatellite instability and promoter methylation of p16 and hMLH1 : a study matched for T classification and tumor location 显示文摘 | Kazama Y Watanabe T Kanazawa T | 2008 | J Surg Oncol2008，97，3： | 1 |
| 10 | Poorly differentiated adenocarcinoma and mucinous carcinoma of the colon and rectum show higher rates of loss of heterozygosity and loss of E-cadherin expression due to methylation of promoter region显示文摘 | Kanazawa T Watanabe T Kazama S | 2002 | Int J Cancer2002，102，3： | 1 |
| 11 | Comparison of the effect side Keo of propofol for blood pressure and EEG bispectral index in eldenly and younger patients显示文摘 | Kazama T Zkedak Moritak | 1999 | Anesthesiology1999，90，： | 1 |
| 12 | Preparation of Mycoplasma hyopneumoniae antigen for the enzyme-linked immunosorbent assay显示文摘 | KAZAMA S YAGIHASHI T SETO K | 1989 | Can J Vet Res1989，53，2： | 1 |
| 13 | Expression of vascular endothelial growth factor C and D (VEGF-C and -D) is an important risk factor for lymphatic metastasis in undifferentiated early gastric carcinoma 显示文摘 | Ishikawa M Kitayama J Kazama S | 2003 | Jpn J Clin Oneot2003，33，1： | 1 |
| 14 | Induction of immuno- logical tolerance by apoptotic cells requires caspase-dependent ox- idation of high-mobility group box-1 protein 显示文摘 | Kazama H Ricci JE Hendon JM | 2008 | Immunity2008，29，1： | 1 |
| 15 | Sepsis-inducedapoptosis leads to active suppression of delayed-type hypersen-sitivity by CD8+regulatory T cells through a TRAIL-dependentmechanism显示文摘 | Unsinger J Kazama H McDonough JS | 2010 | J Immunol2010，184，12： | 1 |
| 16 | Assessment of surface water quality using multivariate statistical techniques: A case study of the Fuji river basin,Japan 显示文摘 | SHRESTHA S KAZAMA F | 2007 | Environmental Modeling Software2007，22，4： | 1 |
| 17 | Optimal propefol plasma cone- entration during upper gastrointestinal endoscopy in young middle-age and elderly patients显示文摘 | Kazama T Takeuchi K Ikeda K | 2000 | Anesthesiology2000，93，3： | 1 |
| 18 | Effects of nitrite inhibition on anaerobic ammonium oxidation 显示文摘 | Kimura Y Isaka K Kazama F | 2010 | Applied Microbiology and Biotechnology2010，86，1： | 1 |
| 19 | Role of fibroblast growth factor 23 in health and in chronic kidney disease显示文摘 | Fukagawa M Nii-Kono T Kazama JJ | 2005 | Curr Opin Nephrol Hypertens2005，14，： | 1 |
| 20 | Classic pulmonary blastoma:a subtype of biphasic pulmonary blastoma显示文摘 | Nakayama T Ohtsuka T Kazama A | 2012 | Ann Thorac Cardiovasc Surg2012，18，2： | 1 |
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