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| 1 | Derivatization in Liquid Chromatography/Mass Spectrometric Analysis of Neurosteroids显示文摘Liquid chromatography/mass spectrometry (LC/MS) is now considered to be the most promising analytical method for the determination of biological substances, especially nonvolatile or highly polar substances However, some compounds do not show enough sensitivity in LC/MS and soft ionization methods commonly used in LC/MS, such as electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI), sometimes do not give satisfactory structural information This report presents an overview of the derivatization methods in the LC/MS analysis of neurosteroids or neuroactive neurosteroids, which are synthesized and accumulated in the nervous system The derivatization of pregnenolone 3 sulfate, one of these steroids, with 4 ( N,N dimethylaminosulfonyl) 7 hydrazino 2,1,3 benzoxadiazole gave a satisfactory sensitivity during the quantitative analysis using LC/ESI MS The obtained results are much lower than those previously obtained using gas chromatography/mass spectrometry or radioimmunoassay On the other hand, the derivatization to acetate was useful for the treatment of labile catechol estrogens in rat brains and gave enough structural information in LC/APCI MS, which confirmed the existence of catechol estrogens in mammalian | Kuniko MITAMURA, Kazutake SHIMADA (Faculty of Pharmaceutical Sciences, Kanazawa University 13 1, Takara machi, Kanazawa 920 0934, Japan) | 2001 | 色谱2001，19，6： | 5 |
| 2 | Simulation of deformation and temperature in multi pass caliber rolling显示文摘 | Kazutake K | 1997 | Journal of Materials Processing Technology1997，71，32： | 1 |
| 3 | Gas chromatography and high- performance liquid chromatography of natural steroids显示文摘 | KAZUTAKE SHIMADA KUNIKO MITAMURA TATSUYA HIGASHI | 2001 | Journal of Chromatography A2001，935，： | 1 |
| 4 | Immunomodulation effects of heat-treated Enterococcus faecalis FK-23(FK-23) in mice显示文摘Objective:The purpose of this study was to evaluate the effects of Enterococcus faecalis FK-23(FK-23) on the immune function in mice. Methods:Mice were treated with three doses of the FK-23(0.05,0.1,0.2,0.6 g/kg body weight) for 30 days. Delayed type hypersensitivity (DTH),monocyte phagocytic function,serum hemolysis antibody and natural killer cell activity were studied. Results:The significant increases in mice treated with 0.6 g/kg bw were found in DTH,phagocytic function of monocyte,serum hemolysis antibody and natural killer cell activity. Conclusion:The results from the present study suggest that FK-23 could improve both specific and nonspecific immune function. | Takashi Shimada Yunqing Cai Lei Cheng Chie Motonaga Kazutake Fukada Yoshihisa Kitamura Jieshu Wu | 2009 | Journal of Nanjing Medical University2009，23，3： | 1 |
| 5 | Simulation of deformation and temperature in multi- pass three -roll rolling 显示文摘 | Kazutake Komori | 1999 | Journal of Materials Processing Technology1999，9293，： | 1 |
| 6 | Simulation of deformation and temperature in multi - pass H - shape rolling 显示文摘 | Kazutake Komori | 2000 | Journal of Materials Processing Technology2000，105，： | 1 |
| 7 | Confirmation, Annulment, Recognition and Enforcement of Arbitral Awards 显示文摘 | KAZUTAKE OKUMA | 2005 | The Seinan Law Review2005，37，4： | 1 |
| 8 | Simulation of deformation and temperature in multi-pass H-shape rolling 显示文摘 | Kazutake K Katsuhiko K | 2000 | Journal of Materials Processing Technology2000，，8： | 1 |
| 9 | Liquid chromatography–tandem mass spectrometric method for the determination of salivary 25-hydroxyvitamin D3: a noninvasive tool for the assessment of vitamin D status显示文摘 | Tatsuya Higashi Yujin Shibayama Mihoko Fuji Kazutake Shimada | 2008 | Analytical and Bioanalytical Chemistry2008，，1： | 1 |
| 10 | Simulation of Deformation and Temperature in Multi-Pass H-Shape Rolling 显示文摘 | Kazutake Komori Katsuhiko Koumura | 2000 | Journal of Materials Processing Technology2000，105，1： | 1 |
| 11 | Simulation of Deformation and Temperature in Press Roll Piercing显示文摘 | Minoru Suzuki | 2005 | Journal of Materials Processing Technology2005，169，： | 1 |
| 12 | Simulation of deformation and tempera-ture in multi-pass H-shape rolling显示文摘 | | 2000 | Journal of Materi-als Processing Technology2000，，105： | 1 |
| 13 | Effect of ductile fracture criteria on chevron crack formation and evolution in drawing 显示文摘 | Komori Kazutake | 2003 | International Journal of Mechanical Sciences2003，45，1： | 1 |
| 14 | Simulation of tensile test by node separation method显示文摘 | Kazutake Komori | 2002 | Journal of Materials Processing Tech2002，，： | 1 |
| 15 | Increased Thermost-ability of Cross Enzyme Crystaly of Subtisin in Organic Solvents,Biotechnology显示文摘 | Hidetaka Noritiomi Kazutake Koyama | 1998 | Techniques1998，12，6： | 1 |
| 16 | Effect of ductile fracture criteria on chevron crack formation and evolution in drawing显示文摘 | Kazutake Komori | 2003 | International Journal of Mechanical Sciences2003，，45： | 1 |
| 17 | Brain activity during expectancy of emotional stimuli:an fMRI study显示文摘 | Ueda Kazutake Okamoto Yasumasa Okada GO | 2003 | Neuroreport2003，14，1： | 1 |
| 18 | Di-2-methoxyethyl azodicarboxylate (DMEAD): an inexpensive and separation-friendly alternative reagent for the Mitsunobu reaction 显示文摘 | Takashi S Kazutake H | 2007 | Chemistry Letters2007，36，4： | 1 |
| 19 | DMEAD: A New Dialkyl Azodicarboxylate for the Mitsunobu Reaction 显示文摘 | Kazutake H Natsuko M Tomonori M | 2009 | Tetrahedron2009，65，31： | 1 |
| 20 | Effect of ductile fracture criteria on chevron crack formation and evolution in drawing显示文摘 | Kazutake Komori | 2003 | International Journal of Mechanical Sciences2003，45，： | 1 |
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