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| 1 | Clinical applications, limitations and future role of transient elastography in the management of liver disease显示文摘Transient elastography(TE) is a reliable tool for the non-invasive assessment of liver fibrosis in routine clinical practice. TE is currently approved for use in Europe, Asia and the United States. The widespread adoption of this technology is certain to increase the use of TE worldwide. Although TE has been well validated in chronic viral hepatitis, its clinical role in other liver diseases remains less clear. The advent of new treatment for chronic hepatitis C and emerging prevalence of non-alcoholic steatohepatitis raises new questions on the role of TE in current clinical practice. This review aims to examine the clinical applications, limitations and future role of TE in current clinical practice in light of the changing epidemiology of liver diseases and new clinical management paradigms. In current clinical practice, TE is the most accurate noninvasive method for diagnosis of liver cirrhosis. TE is useful to rule out fibrosis and cirrhosis but does not have sufficient accuracy to discern between various stages of fibrosis. The clinical role of TE has evolved from cross-sectional point-in-time assessment of fibrosis and cirrhosis to the more relevant role of prediction of vital clinical end-points. This provides clinicians with the ability to modify treatment strategies based on the information provided by TE. TE has evolved over the past decade to become an essential tool to assist the clinician in the management of chronic liver disease. | Pik Eu Chang George Boon-Bee Goh Jing Hieng Ngu Hiang Keat Tan Chee Kiat Tan | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，1： | 5 |
| 2 | Topiramate-associated acute, bilateral, secondary adute-angle closure glaucoma显示文摘 | Fraunfelder FW Fraunfelder FT Keates EU | 2004 | Ophthalmology2004，111，1： | 1 |
| 3 | Topiramate-associated acute, bilateral, secondary angle-closure glaucoma显示文摘 | Fraunfelder FW Fraunfelder FT Keates EU | 2004 | Ophthalmology2004，111，1： | 1 |
| 4 | Topiramateassociated acute, bilateral, secondary, angle-closure glaucoma 显示文摘 | Frauafelder FW Fraunfelder Fr Keates EU | 2004 | Ophthalmology2004，111，1： | 1 |
| 5 | Gamma-globulin in the trabecular meshwork of glaucomatous eyes显示文摘 | Becker B Keates EU Coleman SL | 1962 | Arch Ophthalmol1962，68，11： | 1 |
| 6 | Gamma-globulin in the trabecular meshwork of glaucomatous eyes显示文摘 | Becker B Keates EU Coleman SL | 1962 | Arch Opthalmol1962，68，5： | 1 |
| 7 | Topiramate- associated acute, bilateral, secondary angle-closure glaucoma显示文摘 | Fraunfelder FW Fraunfelder FT Keates EU | 2004 | Ophthalmology2004，111，1： | 1 |
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