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您的检索式：作者名="Kefeng Zhai"
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| 1 | Ginsenoside Rg1 ameliorates bloodebrain barrier disruption and traumatic brain injury via attenuating macrophages derived exosomes miR-21 release显示文摘During the traumatic brain injury(TBI),improved expression of circulatory miR-21 serves as a diagnostic feature.Low levels of exosome-miR-21 in the brain can effectively improve neuroinflammation and bloodebrain barrier(BBB)permeability,reduce nerve apoptosis,restore neural function and ameliorate TBI.We evaluated the role of macrophage derived exosomes-miR-21(M-Exos-miR-21)in disrupting BBB,deteriorating TBI,and Rg1 interventions.IL-1β-induced macrophages(ⅡA)-Exos-miR-21 can activate NF-kB signaling pathway and induce the expressions of MMP-1,-3 and-9 and downregulate the levels of tight junction proteins(TJPs)deteriorating the BBB.Rg1 reduced miR-21-5 p content in ⅡA-Exos(RⅡA-Exos).The interaction of NMIIAe HSP90 controlled the release of Exos-miR-21,this interaction was restricted by Rg1.Rg1 could inhibit the Exos-miR-21 release in peripheral blood flow to brain,enhancing TIMP3 protein expression,MMPs proteolysis,and restricting TJPs degradation thus protected the BBB integrity.Conclusively,Rg1 can improve the cerebrovascular endothelial injury and hold the therapeutic potential against TBI disease. | Kefeng Zhai Hong Duan Wei Wang Siyu Zhao Ghulam Jilany Khan Mengting Wang Yuhan Zhang Kiran Thakur Xuemei Fang Chao Wu Jianbo Xiao Zhaojun Wei | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 6 |
| 2 | Effect of temperature field on solidification structure of pure Al under pulse magneto-oscillation显示文摘This article discusses the effect of temperature field on the Pulse Magneto-Oscillation(PMO) induced solidification refinement of pure aluminium to provide more information for the industrial application of the PMO solidification technology.The temperature field is altered mainly by applied variable cooling conditions and pulse parameters.Experimental results show that the refinement effect in the case of full sand mould applied is weakened with the decreasing of cooling rate,however,in the alternative case,the sand mould whose sand bottom was replaced by a graphite block is favorable to the survival of equiaxed nucleus.The refinement mechanism is discussed in terms of the relationship between temperature field and the formation process of solidified structure.The formation or survival of nucleus depends on both temperature field and Joule heat produced by PMO,both low pulse frequency and high pulse current were experimentally confirmed to be effective;and PMO was demonstrated high potential in industrial application. | Li Bo Yin Zhenxing Gong Yongyong LJ Kefeng Zheng Hongxing Li Renxing Zhai Qijie | 2011 | China Foundry2011，8，2： | 6 |
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