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| 1 | A novel approach of testability modeling and analysis for PHM systems based on failure evolution mechanism显示文摘Prognostics and health management (PHM) significantly improves system availability and reliability, and reduces the cost of system operations. Design for testability (DFT) developed concurrently with system design is an important way to improve PHM capability. Testability modeling and analysis are the foundation of DFT. This paper proposes a novel approach of testability modeling and analysis based on failure evolution mechanisms. At the component level, the fault progression-related information of each unit under test (UUT) in a system is obtained by means of failure modes, evolution mechanisms, effects and criticality analysis (FMEMECA), and then the failure-symptom dependency can be generated. At the system level, the dynamic attributes of UUTs are assigned by using the bond graph methodology, and then the symptom-test dependency can be obtained by means of the functional flow method. Based on the failure-symptom and symptom-test dependencies, testability analysis for PHM systems can be realized. A shunt motor is used to verify the application of the approach proposed in this paper. Experimental results show that this approach is able to be applied to testability modeling and analysis for PHM systems very well, and the analysis results can provide a guide for engineers to design for testability in order to improve PHM performance. | Tan Xiaodong Qiu Jing Liu Guanjun Lv Kehong Yang Shuming Wang Chao | 2013 | Chinese Journal of Aeronautics2013，26，3： | 14 |
| 2 | Environmental stress level evaluation approach based on physical model and interval grey association degree显示文摘Associating environmental stresses (ESs) with built-in test (BIT) output is an important means to help diagnose intermittent faults (IFs). Aiming at low efficiency in association of traditional time stress measurement device (TSMD), an association model is built. Thereafter, a novel approach is given to evaluate the integrated environmental stress (IES) level. Firstly, the selection principle and approach of main environmental stresses (MESs) and key characteristic parameters (KCPs) are presented based on fault mode, mechanism, and ESs analysis (FMMEA). Secondly, reference stress events (RSEs) are constructed by dividing IES into three stress levels according to its impact on faults; and then the association model between integrated environmental stress event (IESE) and BIT output is built. Thirdly, an interval grey association approach to evaluate IES level is proposed due to the interval number of IES value. Consequently, the association output can be obtained as well. Finally, a case study is presented to demonstrate the proposed approach. Results show the proposed model and approach are effective and feasible. This approach can be used to guide ESs measure, record, and association. It is well suited for on-line assistant diagnosis of faults, especially IFs. | Deng Guanqian Qiu Jing Liu Guanjun Lv Kehong | 2013 | Chinese Journal of Aeronautics2013，26，2： | 7 |
| 3 | Engineering CeO_(2)/CuO heterostructure anchored on upconversion nanoparticles with boosting ROS generation-primed apoptosisferroptosis for cancer dynamic therapy显示文摘Highly toxic reactive oxygen species(ROS)induced apoptosis and ferroptosis have been considered as significant cell death pathways for cancer therapy.However,insufficient amount of intracellular ROS extremely restricts the therapeutic effect.Toward this,we report a rationally designed nanocomposite(mUCC)with enhanced ROS generation ability,inducing the combination of apoptosis and ferroptosis through synergistic photodynamic therapy(PDT)and chemodynamic therapy(CDT).Under 808 nm near-infrared(NIR)light irradiation,photocatalytic reaction is triggered starting from the separation of electron-hole pairs on the surface of heterojunction(CeO_(2)/CuO),realizing improved ROS production.Simultaneously,mUCC served as Fenton-like agent exhibits considerable ability to generate highly toxic·OH under tumor microenvironment(TME).The boosted accumulation of ROS disrupts the redox balance within tumor cells and results in the integration of apoptosis and ferroptosis.In addition,mUCC shows satisfactory tumor targeting property benefiting from the cancer cell membrane functionalization under the guidance of magnetic resonance imaging(MRI)and NIR fluorescence imaging.The intelligent mUCC with good biocompatibility and excellent antitumor response achieves efficient tumor elimination under synergistic PDT and CDT.This work offers an elective approach for further development of ROS-based therapeutic nanoplatform in cancer therapy. | Xuan Gao Jing Feng Kehong Lv Yifei Zhou Ruohao Zhang Shuyan Song Hongjie Zhang Daguang Wang | 2023 | Nano Research2023，16，4： | 1 |
| 4 | Utilizing dual-pathway energy transfer in upconversion nanoconjugates for reinforced photodynamic therapy显示文摘Enhancing the therapeutic effect of existing treatments or developing new non-invasive treatments are important measures to achieve high-efficiency treatment of malignant tumors.Photodynamic therapy(PDT)is an emerging treatment modality,and the key for achieving high-efficiency PDT is to select light with strong tissue penetration depth and enhance the generation of reactive oxygen species(ROS).Although the upconversion nanoparticles(UCNPs)modified with the photosensitizers could achieve PDT with strong penetration depth under near-infrared light irradiation,the ROS generated by traditional single-pathway PDT is still insufficient.Herein,we developed a novel nanoconjugate(UCNP-Ce6/AIEgen)for dual-pathway reinforced PDT,in which the UCNPs were co-modified with chlorin e6(Ce6)and luminogen with aggregation-induced emission(AIEgen).Due to the presence of AIEgen,UCNP-Ce6/AIEgen could avoid aggregation-caused luminescence quenching in biological water environments and convert upconversion luminescence(UCL)of UCNPs to Ce6-activatable fluorescence.Therefore,under the irradiation of 808 nm laser,UCNP-Ce6/AIEgen can not only undergo direct lanthanide-triplet energy transfer to activate Ce6,but also convert the UCL of UCNPs to the light that can activate Ce6 through Fӧrster resonance energy transfer to generate more ROS,thus promoting tumor cell apoptosis.This work broadens the applications of nanoconjugates of lanthanide-based inorganic materials and organic dyes,and provides a conception for reinforced PDT of tumors. | Ruohao Zhang Yu Lu Yifei Zhou Kehong Lv Xinyu Fu Jitong Gong Shuang Yao Xiaozhen Wang Jing Feng Hongjie Zhang | 2024 | Nano Research2024，17，4： | 0 |
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