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| 1 | A case of invasive hemolymphangioma of the pancreas显示文摘Hemolymphangioma of the pancreas is a very rare benign tumor. There were only five reports of this disease until March 2008. Herein, we report a case of hemolymphangioma of the pancreas with gastrointestinal bleeding due to duodenal invasion. A 53-year-old man had been admitted a referral hospital because of severe anemia due to gastrointestinal bleeding in December 2005. He was then transferred to our institute with a diagnosis of a tumor of the head of the pancreas with duodenal invasion in January 2006. No abnormalities were revealed except for anemia in laboratory data including CEA and CA19-9. Gastrointestinal endoscopy revealed bleeding at the duodenum. Computed tomography also demonstrated a heterogenous mass at the pancreatic head and suspected invasion to the duodenal wall. Ultrasonography showed a huge mass at the pancreatic head with a mixture of high and low echoic areas. Pylorous-preserving pancreatoduodenectomy was performed. The pancreatic tumor was soft and had invaded to the duodenum. The pathological diagnosis was a hemolymphangioma of the pancreas invaded to the duodenum. His postoperative course was uneventful and he was discharged on the 26th d after surgery. Hemolymphangioma of the pancreas is a very rare benign tumor. In a literature review until March 2008, we found five case reports. Major symptoms are abdominal pain and distension due to the enlarged tumor. However, we experienced a case of hemolymphangioma of the pancreas with gastrointestinal bleeding due to invasion to the duodenum. This disease is a very rare entity, but should be considered when patients have gastrointestinal bleeding. | Yoshikazu Toyoki Kenichi Hakamada Shunji Narumi Masaki Nara Daisuke Kudoh Keinosuke Ishido Mutsuo Sasaki | 2008 | World Journal of Gastroenterology2008，14，18： | 26 |
| 2 | Hemosuccus pancreaticus: Problems and pitfalls in diagnosis and treatment显示文摘Hemosuccus pancreaticus is a rare cause of intermittent upper gastrointestinal bleeding. We report two cases of hemosuccus pancreaticus with multiple episodes of upper gastrointestinal bleeding. The causes of hemorrhage were rupture of pseudoaneurysm of the splenic artery and bleeding from the wall of pancreatic pseudocyst. Interventional radiology is the first modality for early diagnosis and possible treatment of hemosuccus pancreaticus. When angiography shows no abnormal findings or interventional radiological therapy can not be successful, surgery should be considered without delay. Our patients herein underwent surgery without recurrence or sequelae. Intraoperative ultrasonography and pancreatoscopy were helpful modalities for confirming the source of hemorrhage and determining the cutting line of the pancreas. When we encounter intermittent upper gastrointestinal bleeding with an obscure source, hemosuccus pancreaticus should be included in differential diagnoses especially in patients with chronic pancreatitis, which would lead to a prompt and proper treatment. | Yoshikazu Toyoki Kenichi Hakamada Shunji Narumi Masaki Nara Keinosuke Ishido Mutsuo Sasaki | 2008 | World Journal of Gastroenterology2008，14，17： | 5 |
| 3 | Des-gamma-carboxy prothrombin as an important prognostic indicator in patients with small hepatocellular carcinoma显示文摘AIM:To clarify the effect of a high des-gamma-carboxy prothrombin (DCP) level on the invasiveness and prognosis of small hepatocellular carcinoma. METHODS: Among 142 consecutive patients with known DCP levels, who underwent hepatectomy because of hepatocellular carcinoma, 85 patients met the criteria for small hepatocellular carcinoma, i.e. one ≤ 5 cm sized single tumor or no more than three ≤ 3 cm sized tumors. RESULTS: The overall survival rate of the 142 patients was 92.1% for 1 year, 69.6% for 3 years, and 56.9% for 5 years. Multivariate analysis showed that microscopic vascular invasion (P = 0.03) and serum DCP ≥ 400 mAU/mL (P = 0.02) were independent prognostic factors. In the group of patients who met the criteria for small hepatocellular carcinoma, DCP ≥ 400 mAU/mL was found to be an independent prognostic factor for recurrence-free (P = 0.02) and overall survival (P = 0.0005). In patients who did not meet the criteria, the presence of vascular invasion was an independent factor for recurrence-free (P = 0.02) and overall survivals (P = 0.01). In 75% of patients with small hepatocellular carcinoma and high DCP levels, recurrence occurred extrahepatically. CONCLUSION: For small hepatocellular carcinoma, a high preoperative DCP level appears indicative fortumor recurrence. Because many patients with a high preoperative DCP level develop extrahepatic recurrence, it is necessary to screen the whole body. | Kenichi Hakamada Norihisa Kimura Takuya Miura Hajime Morohashi Keinosuke Ishido Masaki Nara Yoshikazu Toyoki Shunji Narumi Mutsuo Sasaki | 2008 | World Journal of Gastroenterology2008，14，9： | 4 |
| 4 | Estimation of the gradient of a density function and its applications in pattern recognition显示文摘 | Fukunaga Keinosuke Hostetler Larry D | 1973 | American Society of Mechanical Engineers (Paper)1973，，： | 1 |
| 5 | The estimation of the gradient of a density function with applications in pattern recognition 显示文摘 | Keinosuke Fukunaga and Larry Hostetler | 1975 | IEEE Transactions on Information Theory1975，21，1： | 1 |
| 6 | Spatial resolution improvement for ultrasonic imaging of an object consisting of multiple planes with level differences using contour xtraction显示文摘 | Michitoshi N Koichi M Keinosuke N | | 0，，6： | 1 |
| 7 | Resection of a locally advanced hilar tumor and the hepatic artery after stepwise hepatic arterial embolization: A case report显示文摘We herein report a case of a hilar tumor with extensive invasion to the proper hepatic artery, which was successfully treated with a radical resection in a 57-year-old female patient after a stepwise hepatic arterial embolization. She underwent right colectomy and partial hepatectomy for advanced colon cancer two years ago and radiofrequency ablation therapy for a liver metastasis one year ago, respectively. A recurrent tumor was noted around the proper hepatic artery with invasion to the left hepatic duct and right hepatic artery 7 mo previously. We planned a radical resection for the patient 5 mo after the absence of tumor progression was confirmed while he was undergoing chemotherapy. To avoid surgery-related liver failure, we tried to promote the formation of collateral hepatic arteries after stepwise arterial embolizationof the posterior and anterior hepatic arteries two weeks apart. Finally, the proper hepatic artery was occluded after formation of collateral flow from the inferior phrenic and superior mesenteric arteries was confirmed. One month later, a left hepatectomy with hepatic arterial resection was successfully performed without any major complications. | Takuya Miura Kenichi Hakamada Takashi Ohata Shunji Narumi Yoshikazu Toyoki Masaki Nara Keinosuke Ishido Motonari Ohashi Harue Akasaka Hiroyuki Jin Norihito Kubo Shuichi Ono Hiroshi Kijima Mutsuo Sasaki | 2008 | World Journal of Gastroenterology2008，14，22： | 1 |
| 8 | The estimation of the gradient of a density function,with applications in pattern recognition显示文摘 | Keinosuke Fukunaga | 1975 | IEEE Trans on Inf Theory1975，21，1： | 1 |
| 9 | Estimation of the gradient of a density function and its applications in pattern recognition 显示文摘 | Fukunaga Keinosuke Hostetler D Larry | 1973 | American Society of Mechanical Engineers (Paper)1973，，： | 1 |
| 10 | The estimation of the gradient of a density function with application in pattern recognition 显示文摘 | Keinosuke Fukunaga Larry D Hostetler | 1975 | IEEE Transactions on Information Theory1975，21，1： | 1 |
| 11 | Making and fabricating of steel components for jaek-up fig legs显示文摘 | Toshiaid Wake | 1982 | Kawasaki sted Teehnical Report1982，，6： | 1 |
| 12 | The estimation of the gradient of a density function with applications in pattern recognition显示文摘 | Keinosuke Fukunaga Larry D Hosteler | 1975 | IEEE Transactions on information theory1975，21，1： | 1 |
| 13 | The estimation of the gradient of a density function, with applications in pattern recognition 显示文摘 | Fukunaga Keinosuke Hostetler Larry D | 1975 | IEEE Transactions on Information Theory1975，21，1： | 1 |
| 14 | Sonographic demonstration of wall thickness of the gallbladder in pediatric patients with pancreatico-biliary maljunction显示文摘 | Michihiro Sugai Keinosuke Ishido Masaaki Endoh Ryukichi Hada Hirohumi Munakata | 2010 | Journal of Hepato - Biliary - Pancreatic Sciences2010，，3： | 1 |
| 15 | The cytotoxinhemolysin genes of human and eel pathogenic Vibrio vulnificus strains: comparison of nucleotide sequences and application to the genetic grouping显示文摘 | Mitsutoshi S Shin-Ichi M Keinosuke O | 2005 | Microbiol Immunol2005，49，6： | 1 |
| 16 | Calculation of Bayes recognition error for two multivariate Gaussian distributions显示文摘 | Keinosuke Fukunaga Thomas F Krile | 1969 | IEEE Transactions on computers1969，18，： | 1 |
| 17 | The estimation of the gradient of a density function, with applications in pattern recognition 显示文摘 | Fukunaga Keinosuke Hostetler Larry D | 1975 | IEEE Transactions on Information Theory1975，21，1： | 1 |
| 18 | Evaluation of photomutage-nicity and photocytotoxicity of food coloring agents显示文摘 | SAKAE K MASAKI M KEINOSUKE O | 2005 | Mutagenesis2005，20，3： | 1 |
| 19 | Inhibition of ABCBI (MDRI) expression by an siRNA nanopartieulate delivery system to overcome drug resistance in osteosarcoma 显示文摘 | Michiro S Arun KL Keinosuke R | 2010 | P Los 0ne2010，5，10： | 1 |
| 20 | The estimation of the gradient of a density function,with applications in pat- tern recognition 显示文摘 | Fukunaga Keinosuke Hostetler Larry D | 1975 | IEEE Transactions on Information Theory1975，21，1： | 1 |
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