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| 1 | Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study显示文摘 | Keith C Bible Vera J Suman Julian R Molina Robert C Smallridge William J Maples Michael E Menefee Joseph Rubin Kostandinos Sideras John C Morris Bryan McIver Jill K Burton Kevin P Webster Carolyn Bieber Anne M Traynor Patrick J Flynn Boon Cher Goh Hui Tan | 2010 | Lancet Oncology2010，，10： | 1 |
| 2 | Chemistry of inclole glucosinolates: intermediacy of indol-3-ylmethyl isothiocyanates in the enzymic hydrolysis of indole glucosinolates显示文摘 | A BRYAN HANLEY KEITH R PARSLEY JENNY A | 1990 | J Chem Soc Perkin Trans1990，1，： | 1 |
| 3 | Acute and repeated dose (28 day) mouse oral toxicology studies with Cry34Ab1 and Cry35Ab1 Bt proteins used in coleopteran resistant DAS-59122-7 corn显示文摘 | Daland R. Juberg Rod A. Herman Johnson Thomas Keith J. Brooks Bryan Delaney | 2009 | Regulatory Toxicology and Pharmacology2009，，2： | 1 |
| 4 | Endothelial HIF-2[alpha] regulates murine pathological angiogenesis and revascularization processes显示文摘 | Skuli Nicolas Majmundar Amar J Krock Bryan L Mesquita Rickson C Mathew Lijoy K Quinn Zachary L Runge Anja Liu Liping Kim Meeri N Liang Jiaming Schenkel Steven Yodh Arjun G Keith Brian Simon M Celeste | 2012 | EN2012，，4： | 1 |
| 5 | Prevalence of CKD and Comorbid Illness in Elderly Patients in the United States: Results From the Kidney Early Evaluation Program (KEEP)显示文摘 | Lesley A. Stevens Suying Li Changchun Wang Cindy Huang Bryan N. Becker Andrew S. Bomback Wendy Weinstock Brown Nilka Ríos Burrows Claudine T. Jurkovitz Samy I. McFarlane Keith C. Norris Michael Shlipak Adam T. Whaley-Connell Shu-Cheng Chen George L. Bakri | 2010 | American Journal of Kidney Diseases2010，，3： | 1 |
| 6 | A combination of density-based clustering method and DEM to numerically investigate the breakage of bonded pharmaceutical granules in the ball milling process显示文摘Ball milling is widely used in industry to mill particulate material.The primary purpose of this process is to attain an appropriate product size with the least possible energy consumption.The process is also extensively utilised in pharmaceuticals for the comminution of the excipients or drugs.Surprisingly,for ball mill,little is known concerning the mechanism of size reduction.Traditional prediction approaches are not deemed useful to provide significant insights into the operation or facilitate radical step changes in performance.Therefore,the discrete element method(DEM)as a computational modelling approach has been used in this paper.In previous research,DEM has been applied to simulate breaking behaviour through the impact energy of all ball collisions as the driving force for fracturing.However,the nature of pharmaceutical material fragmentation during ball milling is more complex.Suitable functional equations which link broken media and applied energy do not consider the collision of particulate media of different shapes or collisions of particulate media(such as granules)with balls and rotating mill drum.This could have a significant impact on fragmentation.Therefore,this paper aimed to investigate the fragmentation of bounded particles into DEM granules of different shape/size during the ball milling process.A systematic study was undertaken to explore the effect of milling speed on breakage behaviour.Also,in this study,a combination of a density-based clustering method and discrete element method was employed to numerically investigate the number and size of the fragments generated during the ball milling process over time.It was discovered that the collisions of the ball increased proportionally with rotation speed until reaching the critical rotation speed.Consequently,results illustrate that with an increase of rotation speed,the mill power increased correspondingly.The caratacting motion of mill material together with balls was identified as the most effective regime regarding the fragmentation,and fewer breakage events occurred for centrifugal motion.Higher quantities of the fines in each batch were produced with increased milling speed with less quantities of grain fragments.Moreover,the relationship between the number of produced fragment and milling speed at the end of the process exhibited a linear tendency. | Alexander Krok Peter Peciar Kieran Coffey Keith Bryan Sandra Lenihan | 2021 | Particuology2021，19，5： | 0 |
| 7 | Compaction analysis and optimisation of convex-faced pharmaceutical tablets using numerical techniques显示文摘Capping failure,edge chipping,and non-uniform mechanical properties of convex-faced pharmaceutical tablets are common problems in the pharma industry.In this paper,the finite element method(FEM)and design of experiment techniques are used to determine the optimal shape of convex-faced(CF)pharmaceutical tablet which has more uniform mechanical properties and less capping and chipping tendency.The effects of different geometrical parameters and friction on the compaction responses of convex-faced pharmaceutical tablets were first identified and analysed.An FEM model of the tabletting process was generated using the implicit code ABAQUS and validated against experimental measurements.Response surface methodology was used to establish the relationship between the design variables,represented by the geometrical parameters and friction coefficient,and compaction responses of interest including residual die pressure,relative density variation within a tablet,and relative shear stress at the edge of a tablet.A statistical-based optimisation approach was then used to optimise the shape of CF tablets.The obtained results demonstrated how the geometrical parameters and friction coefficient of CF pharmaceutical tablets strongly affect their compaction behaviour and quality. | Ahmad Baroutaji Sandra Lenihan Keith Bryan | 2019 | Particuology2019，17，6： | 0 |
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