|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Employee performance cues in a hotel service environment: influence on perceived service quality, value, and word-of-mouth intentions显示文摘 | Michael D H Keith C J | 1996 | Journal of Business Research1996，35，6： | 1 |
| 3 | Cloning of a delta opioid receptor by functional expression显示文摘 | Evans C J Keith D E Morrison H | 1992 | Science1992，258，5090： | 1 |
| 4 | Employee performance cues in a hotelservice environment:influence on perceived service quality,value,and word-of-mouth intentions显示文摘 | Michael D H Keith C J | 1996 | Journal of Business Research1996，35，6： | 1 |
| 5 | Knowledge sharing between design and manufacture 显示文摘 | COCHRANE S D KEITH C YOUNG R I | 2005 | Lecture Notes in Computer Science2005，3684，： | 1 |
| 6 | African Americans,hypertension and the renin angiotensin system显示文摘African Americans have exceptionally high rates of hypertension and hypertension related complications. It is commonly reported that the blood pressure lowering efficacy of renin angiotensin system(RAS) inhibitors is attenuated in African Americans due to a greater likelihood of having a low renin profile. Therefore these agents are often not recommended as initial therapy in African Americans with hypertension. However, the high prevalence of comorbid conditions, such as diabetes, cardiovascular and chronic kidney disease makes treatment with RAS inhibitors more compelling. Despite lower circulating renin levels and a less significant fall in blood pressure in response to RAS inhibitors in African Americans, numerous clinical trials support the efficacy of RAS inhibitors to improve clinical outcomes in this population, especially in those with hypertension and risk factors for cardiovascular and related diseases. Here, we discuss the rationale of RAS blockade as part of a comprehensive approach to attenuate the high rates of premature morbidity and mortality associated with hypertension among African Americans. | Sandra F Williams Susanne B Nicholas Nosratola D Vaziri Keith C Norris | 2014 | World Journal of Cardiology2014，6，9： | 1 |
| 7 | Multi-adaptive filterin technique for surface somatosensory evoked potentials processing显示文摘 | Benny S C HU Yong Keith D K L et ol | 2005 | Med Eng & Physics2005，27，： | 1 |
| 8 | Percutaneous management of bile duct strictures and injuries associated with laparoscopic cholecystectomy: a decade of experience显示文摘 | Sanjay Misra Genevieve B Melton J.F Geschwind Anthony C Venbrux John L Cameron Keith D Lillemoe | 2004 | Journal of the American College of Surgeons2004，，2： | 1 |
| 9 | Diabetic neuropathy: An intensive review 显示文摘 | Jeremiah John D R Keith C Setter SM | 2004 | Am J Health Syst Pharm2004，61，2： | 1 |
| 10 | The effect of liquid water on thunderstorm charging显示文摘 | W D Keith R P Mitzeva | 1991 | J Geophys Res1991，96，11： | 1 |
| 11 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 12 | Adeno-associated virusmediated bone morphogenetic protein-4 gene therapy for in vivo bone formation显示文摘 | Keith D K Yan C Kenneth M C | 2003 | Biochem Biophys Res Commun2003，308，： | 1 |
| 13 | Theinfluence of large-scale wind power on global climate 显示文摘 | Keith D W DeCarolls J F Denkenberger D C | 2004 | PNAS2004，16，16： | 1 |
| 14 | Cloning of delta opioid receptor by functional expression 显示文摘 | EVANS C J KEITH D E MORRISON H | 1992 | Science1992，258，5090： | 1 |
| 15 | Pericardiectomy for pericardial constriction显示文摘 | MICHAEL C TROTER M D KEITH C | 1996 | Am Surg1996，62，4： | 1 |
| 16 | Multi-adaptive filtering technique for surface somatosensory evoked potentials processing显示文摘 | Benny S C HIJ Yong Keith D K L | 2005 | Med Eng & Physics2005，27，： | 1 |
| 17 | Liquid deposition photolithography for submicrometer resolution three-dimensional index structuring with large throughput显示文摘Photonic devices increasingly require three-dimensional control of refractive index,but existing fabrication methods such as femtosecond micromachining,multilayer lithography and bulk diffusion can only address a select scale range,are often limited in complexity or thickness and have low throughput.We introduce a new fabrication method and polymeric material that can efficiently create mm^(3) optical devices with programmable,gradient index of refraction with arbitrary feature size.Index contrast of 0.1 is demonstrated,which is 100 times larger than femtosecond micromachining,and 20 times larger than commercial holographic photopolymers.This is achieved by repetitive microfluidic layering of a self-developing photopolymer structured by projection lithography.The process has the unusual property that total fabrication time for a fixed thickness decreases with the number of layers,enabling fabrication 10^(5) faster than femtosecond micromachining.We demonstrate the process by sequentially writing 100 layers to fabricate a mm thick waveguide array. | Adam C Urness Eric D Moore Keith K Kamysiak Michael C Cole Robert R McLeod | 2013 | Light(Science & Applications)2013，2，1： | 1 |
| 18 | The effect of liquid water on thunderstorm charging 显示文摘 | Saunders C P R Keith W D Mitzeva R P | 1991 | J Geophys Res1991，96，11： | 1 |
| 19 | Germination and establishment with root- zone amendments显示文摘 | Cale A Bigelow Dan C Bowman Ph D D Keith Cassel | 1999 | Journal of Experimental Botany1999，50，2： | 1 |
| 20 | Impacts of land-use change on hydrologic responses in the Great Lakes region 显示文摘 | Mao D Keith A C | 2009 | Journal of Hydrology2009，374，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员