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| 1 | Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma显示文摘Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis,cancer,and liver failure.Liver cancer is the third leading cause of cancer-associated mortality,of which hepatocellular carcinoma(HCC)represents 90%of all primary liver cancers.Solid tumors like HCC are complex and have heterogeneous tumor genomic profiles contributing to complexity in diagnosis and management.Chronic infection with hepatitis B virus(HBV),hepatitis delta virus(HDV),and hepatitis C virus(HCV)are the greatest etiological risk factors for HCC.Due to the significant role of chronic viral infection in HCC development,it is important to investigate direct(viral associated)and indirect(immune-associated)mechanisms involved in the pathogenesis of HCC.Common mechanisms used by HBV,HCV,and HDV that drive hepatocarcinogenesis include persistent liver inflammation with an impaired antiviral immune response,immune and viral protein-mediated oxidative stress,and deregulation of cellular signaling pathways by viral proteins.DNA integration to promote genome instability is a feature of HBV infection,and metabolic reprogramming leading to steatosis is driven by HCV infection.The current review aims to provide a brief overview of HBV,HCV and HDV molecular biology,and highlight specific viral-associated oncogenic mechanisms and common molecular pathways deregulated in HCC,and current as well as emerging treatments for HCC. | Simmone D'souza Keith CK Lau Carla S Coffin Trushar R Patel | 2020 | World Journal of Gastroenterology2020，26，38： | 25 |
| 2 | Analytical methods for detection of selected estrogenic compounds in aqueous mixtures 显示文摘 | Snyder S A Keith T L Verbrugge D A | 1999 | Environ Sci Technol1999，33，16： | 2 |
| 3 | On the role of Mn (IV) vacancies in the photoreductive dissolution of hexagonal birnessite显示文摘 | KIDEOK D K KEITH R GARRISON S | 2009 | Geochimica et Cosmochimica Acta2009，73，： | 1 |
| 4 | Knowledge sharing between design and manufacture 显示文摘 | COCHRANE S D KEITH C YOUNG R I | 2005 | Lecture Notes in Computer Science2005，3684，： | 1 |
| 5 | Multi-adaptive filterin technique for surface somatosensory evoked potentials processing显示文摘 | Benny S C HU Yong Keith D K L et ol | 2005 | Med Eng & Physics2005，27，： | 1 |
| 6 | Geomechanical modeling for CO2 storage in Nisku aquifer in Wabamun Lake area in Canada显示文摘 | GOODARZI S SETTARI A KEITH D | 2012 | International Journal of Greenhouse Gas Control2012，10，10： | 1 |
| 7 | Mobilization of PAHs and PCBs from in-place contaminated marine sediments during simulated resuspension events显示文摘 | LATIMER J S DAVIS W R KEITH D J | 1999 | Estuarine Coastal and Shelf Science1999，49，4： | 1 |
| 8 | Review:infrared spec-troscopy-enabling an evidence-based diagnostic surveillance approach to agricultural and environmental management in developing countries显示文摘 | Keith D S Markus G W | 2007 | Journal of Near Infrared Spectroscopy2007，15，1： | 1 |
| 9 | Spatial and temporal distribution of coloured dissolved organic matter (CDOM) in Narragansett Bay, Rhode Island: implications for phytoplankton in coastal waters显示文摘 | Keith D J Yoder J A Freeman S A | 2002 | Estuar Coast Shelf S2002，55，5： | 1 |
| 10 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 11 | Analytical methods for detection of selected estrogenic compounds in aqueous mixtures 显示文摘 | Snyder S A Keith T L Verbrugge D A | 1999 | Environ Sci Technol1999，33，16： | 1 |
| 12 | Multi-adaptive filtering technique for surface somatosensory evoked potentials processing显示文摘 | Benny S C HIJ Yong Keith D K L | 2005 | Med Eng & Physics2005，27，： | 1 |
| 13 | Model for pubilc sector designbuild project selection 显示文摘 | Keith R M Anthony D S | 1998 | Journal of Construction Engineering and Management1998，146，6： | 1 |
| 14 | Analysing initialattack on wildland fires using stochastic simulation显示文摘 | JEREMY S RIED D KEITH J G | 2006 | In-ternational Journal of Woodland Fire2006，15，： | 1 |
| 15 | Spatial and Temporal Distribution of Coloured Dissolved Organic Matter (CDOM) in Narragansett Bay, Rhode Island: Implications for Phytoplankton in Coastal Waters 显示文摘 | KEITH D J YODER J A FREEMAN S A | 2001 | Estuarine Coastal and Shelf Science2001，55，5： | 1 |
| 16 | Resource characterization of the McMurray Wabiskaw deposit in the Athabasca South Region of Northeastern Alberta显示文摘 | MacGillivray J R Strobl R S Keith D A W | | 0，，： | 1 |
| 17 | A new method for bromination of carbazoles,β–carbolines and iminodibenzyls by use of N-bromosuccinimide and silicagel显示文摘 | Keith S D Martin J Anil G M | 1992 | Tetrahedron1992，48，36： | 1 |
| 18 | A new method for bromination of carbazoles ,β-carbolines and imink-odibenzyls by use of N-bromosuccinimide and silica gel 显示文摘 | Keith S D Martin J Anil G M | 1992 | Tetrahedron1992，48，36： | 1 |
| 19 | Effect of increasing anode surface area on the performance of a single chamber microbial fuel cell 显示文摘 | Mirella D L Keith S Tom P C | 2010 | Chemical Enlineerin Journal2010，156，1： | 1 |
| 20 | Comparative analysis of maromoleeules in mollusk shells显示文摘 | Keith J Stockwell S Ball D | 1993 | Comp Biochem Physiol1993，105，： | 1 |
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