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| 1 | Clinical features and management of primary sclerosing cholangitis显示文摘Primary sclerosing cholangitis is a chronic cholestatic liver disease characterized by inflammation and fibrosis of the bile ducts,resulting in cirrhosis and need for liver transplantation and reduced life expectancy.The majority of cases occur in young and middle-aged men,often in association with inflammatory bowel disease.The etiology of primary sclerosing cholangitis includes immune-mediated components and elements of undefined nature.No effective medical therapy has been identified.The multiple complications of primary sclerosing cholangitis include metabolic bone disease,dominant strictures,bacterial cholangitis,and malignancy,particularly cholangiocarcinoma,which is the most lethal complication of primary sclerosing cholangitis.Liver transplantation is currently the only life-extending therapeutic alternative for patients with end-stage disease,although recurrence in the allografted liver has been described.A PSC-like variant attracting attention is cholangitis marked by raised levels of the immunoglobulin G4 subclass,prominence of plasma cells within the lesions,and steroid responsiveness. | Marina G Silveira Keith D Lindor | 2008 | World Journal of Gastroenterology2008，14，21： | 9 |
| 2 | Lymphoepithelial cysts and cystic lymphangiomas: Underrecognized benign cystic lesions of the pancreas显示文摘AIM: To identify their diagnostic and prognostic clinical characteristics in a large series.METHODS: Retrospective review of clinicopathologic and imaging characteristics of patients diagnosed with lymphoepithelial cysts and cystic lymphangiomas of the pancreas at Massachusetts General Hospital.RESULTS: Twelve patients were identified between 1/1/1997 and 8/1/2007. Their median age was 55.5 years(range 19-78 years), and 6 were females. The le-sion was incidentally discovered in half of the patients.Contrast enhanced computed tomography demonstrat-ed that the cysts had thin walls, without calcifications, pancreatic duct dilation or pancreatic parenchyma inva-sion. Endoscopic ultrasound with fine needle aspiration(EUS/FNA) confirmed the diagnosis of a lymphoepithe-lial cyst in 3 patients, one of whom was spared an op-eration and continues to do well after 6 years. Eleven patients had a resection: 3 pancreaticoduodenecto-mies, 7 distal pancreatectomies, and 1 enucleation. The median size of the cysts was 3 cm(range 2-20 cm). At a median follow-up of 57 mo no recurrences or other pancreas-related conditions occurred.CONCLUSION: Lymphoepithelial cysts and cystic lymphangiomas of the pancreas can be diagnosed with a combination of contrast-enhanced computed tomog-raphy scans and EUS/FNA. If the lesion is asymptom-atic, an operation might be avoided. | Ioannis T Konstantinidis Avinash Kambadakone Onofrio A Catalano Dushyant V Sahani Vikram Deshpe David G Forcione Jennifer A Wargo Carlos Fernandez-del Castillo Keith D Lillemoe Andrew L Warshaw Cristina R Ferrone | 2014 | World Journal of Gastrointestinal Surgery2014，6，7： | 2 |
| 3 | Biosensor technology: technology push versus market pull显示文摘 | JOHN H T L KEITH B M JEREMY D G | 2008 | Biotechn Adv2008，26，5： | 1 |
| 4 | Total synthesis of halichondrin B and norhalichondrin B 显示文摘 | Thomas D A Keith R B Francis G F | | J Am Chem Soc t992 114 (8)0，3162，： | 1 |
| 5 | Review:infrared spec-troscopy-enabling an evidence-based diagnostic surveillance approach to agricultural and environmental management in developing countries显示文摘 | Keith D S Markus G W | 2007 | Journal of Near Infrared Spectroscopy2007，15，1： | 1 |
| 6 | Frequent nonreciprocal translocations in the amphidiploid genome of oilseed rape (Brassica napus)显示文摘 | Sharpe A G Pakin I A P Keith D J | 1995 | Genome1995，38，： | 1 |
| 7 | Optical performance as a function dynamic mechanical loading 显示文摘 | VICTOR L G KEITH B D GREGORY J M | 2008 | SPIE2008，5178，4： | 1 |
| 8 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 9 | Identification of the A and C genomes of amphidiploid Brassica napus (oilseed rape) 显示文摘 | Parkin I A P Sharpe A G Keith D J | 1995 | Genome1995，38，6： | 1 |
| 10 | Ventricular septal defect:incidence morbidity and mortality in various age groups显示文摘 | KEITH J D ROSE V COLLINS G | 1971 | Br Heart1971，，： | 1 |
| 11 | VITS - A vision system for autonomous land vehicle navigation 显示文摘 | Turk M A Morgenthaler D G Keith D G | 1988 | IEEE Transactions on Pattern Analysis and Machine Intelligence1988，10，3： | 1 |
| 12 | BAI 3, CDX 2 and VIL 1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas显示文摘 | Muhammad F Bari Helen Brown Andrew G Nicholson Keith M Kerr John R Gosney William A Wallace Irshad Soomro Salli Muller Danielle Peat Jonathan D Moore Lesley A Ward Maxim B Freidin Eric Lim Manu Vatish David R J Snead | 2014 | Histopathology2014，，： | 1 |
| 13 | Plant functional traits in relation to fire in crown-fire ecosystems显示文摘 | Pausas J G Bradstock R A Keith D A | 2004 | Ecology2004，85，4： | 1 |
| 14 | Low temperature processes in a bituminous coal studied by in situ electron spin resonance spectroscopy显示文摘 | Fowler T G Keith B D Rafael Kandiyoti | 1987 | Fuel1987，66，： | 1 |
| 15 | Lipid-lowering effect of a dietary chromium (III)-nicotinic acid complex in male athletes 显示文摘 | Lefavi R G Wilson G D Keith R E | 1993 | Nutrition research1993，13，： | 1 |
| 16 | Carbon dioxide capture from atmospheric air using sodium hydroxide spray 显示文摘 | Stolaroff J K Keith D W Lowry G V | 2008 | Environmental Science & Technology2008，42，8： | 1 |
| 17 | Using CaO- and MgO-rich industrial waste stream for carbon sequestration 显示文摘 | StolaroffJ Lowry G Keith D | 2005 | Energy Cinvers Manage2005，46，： | 1 |
| 18 | Subjective judgments by climate experts显示文摘 | Morgan M G Keith D W | 1995 | Environmental Science & Technology1995，29，10： | 1 |
| 19 | Response of metal- lic pyramidal lattice core sandwich panels to high intensity im- pulsive loading in air显示文摘 | Kumar P D Haydn N G W Keith W | 2011 | International Journal of Impact Engi- neering2011，38，5： | 1 |
| 20 | Using CaO and MgO rich in- dustrial waste streams for carbon sequestration 显示文摘 | Stolaroff J K Lowry G V Keith D W | 2005 | Energy Conver- sion Management2005，46，5： | 1 |
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