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| 1 | Histological healing favors lower risk of colon carcinoma in extensive ulcerative colitis显示文摘AIM:To search for the answer in extensive ulcerative colitis as to whether histological inflammation persisting despite endoscopic mucosal healing serves to increase the risk of colon cancer(CC)or high grade dysplasia(HGD).METHODS:This is a single center(Lenox Hill Hospital)retrospective cohort and descriptive study of extensive ulcerative colitis(UC)for 20 years or more with a minimum of 3 surveillance colonoscopies and biopsies performed after the first 10 years of UC diagnosis.Data analyzed included:duration of UC,date of diagnosis of(CC)or(HGD),number of surveillance colonoscopies,and biopsies showing histological inflammation and its severity in each of 6 segments when endoscopic appearance is normal.Two subgroups of patients were compared:group 1 patients who developed CC/HGD and group 2 patients who did not develop CC/HGD.RESULTS:Of 115 patients with longstanding UC reviewed,68 patients met the inclusion criteria.Twenty patients were in group 1 and 48 in group 2.We identified the number of times for each patient when the endoscopic appearance was normal but biopsies nevertheless showed inflammation.Overall,histological disease activity in the absence of gross/endoscopic disease was found in 31.2%(95%CI:28%-35%)of colonoscopies performed on the entire cohort of 68 patients.Histological disease activity when the colonoscopy showed an absence of gross disease activity was more common in group 1 than group 2 patients,88%(95%CI:72%-97%)vs 59%(95%CI:53%-64%).Only 3/20(15%)of patients in group 1 ever had a colonoscopy completely without demonstrated disease activity(i.e.,no endoscopic or histological activity)as compared to 37/48(77%)of patients in group 2,and only 3.3%(95%CI:0.09%-8.3%)of colonoscopies in group 1 had no histological inflammation compared to23%(95%CI:20%-27%)in group 2.CONCLUSION:Progression to HGD or CC in extensive ulcerative colitis of long standing was more frequently encountered among those patients who demonstrate persistent histological inflammation in the absence of gross mucosal disease.Our findings support including the elimination of histological inflammation in the definition of mucosal healing,and support this endpoint as an appropriate goal of therapy because of its risk of increasing dysplasia and colon cancer. | Burton I Korelitz Keith Sultan Megha Kothari Leo Arapos Judy Schneider Georgia Panagopoulos | 2014 | World Journal of Gastroenterology2014，20，17： | 4 |
| 2 | Three-week neonatal hypoxia reduces blood CGRP and causes persistent pulmonary hypertension in rats 显示文摘 | Keith I M Tjen-A-Looi S Kraiczi H | 2000 | Am J Physiol Heart Circ Physiol2000，279，4： | 2 |
| 3 | Plant responses to atmospberic CO2 enrichment in the face of enviromental constraints:a review of the past 10 years reseach 显示文摘 | Keith E I Sherwood BI | 1994 | Agricultural and Forest Meteorology1994，69，： | 1 |
| 4 | Knowledge sharing between design and manufacture 显示文摘 | COCHRANE S D KEITH C YOUNG R I | 2005 | Lecture Notes in Computer Science2005，3684，： | 1 |
| 5 | Identification, molec- ular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells显示文摘 | Keith SC Espinosa I Chao M | 2009 | Proc Natl Acad Sci USA2009，106，14： | 1 |
| 6 | The effect of oxygen on the sporulation and toxicity of Bacillus sphericus 2362 显示文摘 | Mohamed I A K Rachel J L Keith J O | 1993 | Biotechnology letters1993，15，1： | 1 |
| 7 | Carbon and Oxygen Isotopic Composition of Selected Limestones and Fossils显示文摘 | Keith M I Weber J N | 1964 | Geochimica et Cosmochimica Acta1964，28，： | 1 |
| 8 | Nucleotide sequence of the structural glycoprotein VP7 gene of nebraska calf diarrhea virus rotavirus: comparison with homologous from four strain of human and animal rotavirus显示文摘 | Glass R I Keith J J Nakagomi O et M | 1985 | Virology1985，141，： | 1 |
| 9 | Frequent nonreciprocal translocations in the amphidiploid genome of oilseed rape (Brassica napus)显示文摘 | Sharpe A G Pakin I A P Keith D J | 1995 | Genome1995，38，： | 1 |
| 10 | Identification of the A and C genomes of amphidiploid Brassica napus (oilseed rape) 显示文摘 | Parkin I A P Sharpe A G Keith D J | 1995 | Genome1995，38，6： | 1 |
| 11 | Modeling and simulation of an electric arc furnace process显示文摘 | GERHARDT J KEITH I CHRISTIAAN P | 1999 | ISIJ International1999，39，1： | 1 |
| 12 | Diabetes and depression显示文摘 | Keith Merkl A Heuser I | 2005 | Dtsch Med Wochenschr2005，130，17： | 1 |
| 13 | Anaesthesia and blood loss in total hip replacement显示文摘 | Keith I | 1977 | Anaesthesia1977，32，3： | 1 |
| 14 | Is sleep apnea an independent risk factor for prevalent and incident diabete] in the Busseh on Health Study? 显示文摘 | Nathaniel S Marshal I Keith K | 2009 | J Clin Sleep Med2009，15，5： | 1 |
| 15 | Dorsal column stimulation for persistent vegetative state显示文摘 | Morita I Keith MW Kanno T | 2007 | Acta Neurochir suppl2007，，： | 1 |
| 16 | Reversible gastroparesis:functional documentation of celiac axis compression syndrome and postoperative improvement显示文摘 | Trinidad-Hernandez M Keith P Habib I | 2006 | Am Surg2006，72，： | 1 |
| 17 | Examining carer stress in dementia:the role of subtype diagnosis and neuropsychiatric symptoms显示文摘 | Lee DR Mc Keith I Mosimann U | 2013 | Int J Geriatr Psychiatry2013，28，2： | 1 |
| 18 | On the possible cause of monozygotic twinning: lessons from the 9-banded armadillo and from assisted reproduction显示文摘 | Blickstein I Keith LG | 2007 | Twin Res Hum Genet2007，10，2： | 1 |
| 19 | The role of endogenous lung neuropeptides in regulation of the pulmonary circulation 显示文摘 | Keith I M | 2000 | Physiol Res2000，49，5： | 1 |
| 20 | Postoperative fatigue negatively impacts the daily lives of patients recovering from hysterectomy显示文摘 | Alan HD Gloria B Keith I | 2002 | Obstet Gynecol2002，99，： | 1 |
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