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6篇 您的检索式：作者名="Keith Killian"

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		题名	作者	年代	出处	被引量
	1	在男吸烟者之中的白血球 DNA methylation 和 colorectal 癌症显示文摘 AIM: To explore the association between methylation in leukocyte DNA and colorectal cancer (CRC) risk in male smokers using the α-tocopherol, β-carotene cancer prevention study. METHODS: About 221 incident CRC cases, and 219controls, frequency-matched on age and smoking intensity were included. DNA methylation of 1505 CpG sites selected from 807 genes were evaluated using Il-lumina GoldenGate Methylation Cancer Panel I in prediagnostic blood leukocytes of study subjects. Tertiles of methylation level classified according to the distribution in controls for each CpG site were used to analyze the association between methylation level and CRC risk with logistic regression. The time between blood draw to cancer diagnosis (classifying cases according to latency) was incorporated in further analyses using proportional odds regression. RESULTS: We found that methylation changes of 31 CpG sites were associated with CRC risk at P<0.01 level. Though none of these 31 sites remained statistically significant after Bonferroni correction, the most statistically significant CpG site associated with CRC risk achieved a Pvalue of 1.0×10-4 . The CpG site is located in DSP gene, and the risk estimate was 1.52 (95% CI: 0.91-2.53) and 2.62 (95% CI: 1.65-4.17) for the second and third tertile comparing with the lowest tertile respectively. Taking the latency information into account strengthened some associations, suggesting that the methylation levels of corresponding sites might change over time with tumor progression. CONCLUSION: The results suggest that the methylation level of some genes were associated with cancer susceptibility and some were related to tumor development over time. Further studies are warranted to confirm and refine our results.	Keith Killian Stephanie Weinstein Jarmo Virtamo Margaret Tucker Philip Taylor Demetrius Albanes Paul Meltzer Neil Caporaso	2012	World Journal of Gastrointestinal Oncology2012，4，8：	2
	2	Energy and environmental aspects of u-sing corn stover for fuel ethano显示文摘	John Sheehan Andy Aden Keith Paus-tian Kentrick Killian John Brenner Marie Walsh Richard Nelson	2003	Journal of Industri-al Ecology Volume 7 Issue 3-4 July 20032003，，：	1
	3	Genomic structure of the human M6P/IGF2 receptor显示文摘	J. Keith Killian Randy L. Jirtle	1999	Mammalian Genome1999，，1：	1
	4	Genomic structure of the human M6P/IGF2 receptor显示文摘	J. Keith Killian Randy L. Jirtle	1999	Mammalian Genome1999，，1：	1
	5	Imprint status of M6P/IGF2R and IGF2 in chickens显示文摘	Catherine M. Nolan J. Keith Killian James N. Petitte Randy L. Jirtle	2001	Development Genes and Evolution2001，，4：	1
	6	Immunohistochemical Loss of Succinate Dehydrogenase Subunit A (SDHA) in Gastrointestinal Stromal Tumors (GISTs) Signals SDHA Germline Mutation显示文摘	Markku Miettinen Jonathan Keith Killian Zeng-Feng Wang Jerzy Lasota Christopher Lau Laura Jones Robert Walker Marbin Pineda Yuelin Jack Zhu Su Y. Kim Lee Helman Paul Meltzer	2013	The American Journal of Surgical Pathology2013，，2：	1

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