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| 1 | A phase 3,double-blind,randomized placebo-controlled efficacy and safety study of abiraterone acetate in chemotherapynaı¨ve patients with mCRPC in China,Malaysia,Thailand and Russia显示文摘Objective:This double-blind,placebo-controlled phase 3 study was designed to compare efficacy and safety of abiraterone acetate+prednisone(abiraterone)to prednisone alone in chemotherapy-naı¨ve,asymptomatic or mildly symptomatic metastatic castrationresistant prostate cancer(mCRPC)patients from China,Malaysia,Thailand and Russia.Methods:Adult chemotherapy-naı¨ve patients with confirmed prostate adenocarcinoma,Eastern Cooperative Oncology Group(ECOG)performance status(PS)grade 0e1,ongoing androgen deprivation(serum testosterone<50 ng/dL)with prostate specific antigen(PSA)or radiographic progression were randomized to receive abiraterone acetate(1000 mg,QD)t prednisone(5 mg,BID)or placebo t prednisone(5 mg,BID),until disease progression,unacceptable toxicity or consent withdrawal.Primary endpoint was improvements in time to PSA progression(TTPP).Results:Totally,313 patients were randomized(abiraterone:n Z 157;prednisone:n Z 156);and baseline characteristics were balanced.At clinical cut-off(median follow-up time:3.9 months),80% patients received treatment(abiraterone:n Z 138,prednisone:n Z 112).Median time to PSA progression was not reached with abiraterone versus 3.8 months for prednisone,attaining 58%reduction in PSA progression risk(HR=0.418;p<0.0001).Abirateronetreated patients had higher confirmed PSA response rate(50%vs.21%;relative odds=2.4;p<0.0001)and were 5 times more likely to achieve radiographic response than prednisonetreated patients(22.9%vs.4.8%,p=0.0369).Median survival was not reached.Most common(≥10% abiraterone vs.prednisone-treated)adverse events:bone pain(7%vs.14%),pain in extremity(6%vs.12%),arthralgia(10%vs.8%),back pain(7%vs.11%),and hypertension(15%vs.14%).Conclusion:Interim analysis confirmed favorable benefit-to-risk ratio of abiraterone in chemotherapy-naı¨ve men with mCRPC,consistent with global study,thus supporting use of abiraterone in this patient population. | Dingwei Ye Yiran Huang Fangjian Zhou Keji Xie Vsevolod Matveev Changling Li Boris Alexeev Ye Tian Mingxing Qiu Hanzhong Li Tie Zhou Peter De Porre Margaret Yu Vahid Naini Hongchuan Liang Zhuli Wu Yinghao Sun | 2017 | Asian Journal of Urology2017，4，2： | 3 |
| 2 | Optimizing Prescription of Chinese Herbal Medicine for Unstable Angina Based on Partially Observable Markov Decision Process显示文摘 | Yan Feng Yu Qiu Xuezhong Zhou Yixin Wang Hao Xu Baoyan Liu Keji Chen | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 1 |
| 3 | Oxidation of aromatic sulfides with molecular oxygen:Controllable synthesis of sulfoxides or sulfones显示文摘The recent development of selective oxidation of aromatic sulfides with molecular oxygen was highlighted.The sulfoxides and sulfones could be obtained by simply switching the reaction media,i.e.,bis(2-butoxyethyl)ether(BBE)or poly(ethylene glycol)dimethyl ether(PEGDME).The application of the high-boiling-point polyether as an initiator and green media can eliminate the need of large quantities of additives and volatile solvents.This strategy represents an economic and eco-friendly method that could find potential applications. | Lili Tang Kejie Du Bing Yu Liangnian He | 2020 | Chinese Chemical Letters2020，31，12： | 1 |
| 4 | The complexities of proanthocyanidin biosynthesis and its regulation in plants显示文摘Proanthocyanidins(PAs)are natural flavan-3-ol polymers that contribute protection to plants under biotic and abiotic stress,benefits to human health,and bitterness and astringency to food products.They are also potential targets for carbon sequestration for climate mitigation.In recent years,from model species to commercial crops,research has moved closer to elucidating the flux control and channeling,subunit biosynthesis and polymerization,transport mechanisms,and regulatory networks involved in plant PA metabolism.This review extends the conventional understanding with recent findings that provide new insights to address lingering questions and focus strategies for manipulating PA traits in plants. | Keji Yu Yushuang Song Jinxing Lin Richard A.Dixon | 2023 | Plant Communications2023，4，2： | 0 |
| 5 | Protective effects of oleic acid and polyphenols in extra virgin olive oil on cardiovascular diseases显示文摘The Mediterranean diet has long been recognized as one of the most effective ways to prevent and improve cardiovascular disease.Extra virgin olive oil(EVOO)is the typical sources of fat in the Mediterranean diet which have been shown to have noteworthy nutritional value and positive impact on human health.It is worth noting that EVOO owes its superior nutritional value to its bioactive composition.The main component of EVOO is monounsaturated fatty acids(MUFAs)in the form of oleic acid.Oleic acid accounts for up to 70%-80%of EVOO.Secondly,EVOO contains approximately more than 30 phenolic compounds,of which HT is essential for the protection against cardiovascular diseases.In this review,we focused on the potential mechanisms of oleic acid and polyphenols combat cardiovascular diseases risk in terms of oxidative stress,inflammation,blood pressure,endothelial function and cholesterol.This review might provide a reference for the studies on cardiovascular protective effects of EVOO. | Yan Lu Jun Zhao Qiqi Xin Rong Yuan Yu Miao Manli Yang Hui Mo Keji Chen Weihong Cong | 2024 | Food Science and Human Wellness2024，13，2： | 0 |
| 6 | Status Quo of Maker Spaces in Main Urban Area of Chengdu显示文摘This paper, based on the literature review and field investigation, studied the status quo of maker spaces in main urban district of Chengdu at a time when the development of the maker spaces has received strong support from national and local governments. In addition to introducing the related concepts and policy support of the maker space, it summarized its distribution characteristics, audience characteristics, and status quo as well as problems and presented the direction for the development of the maker space in main urban area of Chengdu grounded on a survey of the status quo of national maker spaces in main urban area of Chengdu. | GAO Wei LIU Pan LIANG Zihan HOU Junzheng LUO Tianze LU Baorong WANG Xufei YU Xinyu FENG Yajin REN Zijie DU Jinqiang BAI Yile WANG Kejie SUN Zhentong | 2017 | Journal of Landscape Research2017，9，4： | 0 |
| 7 | Biofabrication of aligned structures that guide cell orientation and applications in tissue engineering显示文摘The organized alignment of cells in various tissues plays a significant role in the maintenance of specific functions.To induce such an alignment,ideal scaffolds should simulate the characteristics and morphologies of natural tissues.Aligned structures that guide cell orientation are used to facilitate tissue regeneration and repair.We here review how various aligned structures are fabricated,including aligned electrospun nanofibers,aligned porous or channeled structures,micropatterns and combinations thereof,and their application in nerve,skeletal muscle,tendon,and tubular dentin regeneration.The future use of aligned structures in tissue engineering is also discussed. | Kejie Lu Ying Qian Jiaxing Gong Ziyu Zhu Jun Yin Liang Ma Mengfei Yu Huiming Wang | 2021 | Bio-Design and Manufacturing2021，4，2： | 0 |
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