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| 1 | Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial显示文摘AIM To evaluate the effect of sitagliptin vs placebo on histologic and non-histologic parameters of nonalcoholic steatohepatitis(NASH).METHODS Twelve patients with biopsy-proven NASH were randomized to sitagliptin(100 mg daily)(n=6)or placebo(n=6)for 24 wk.The primary outcome was improvement in liver fibrosis after 24 wk.Secondary outcomes included evaluation of changes in NAFLD activity score(NAS),individual components of NAS(hepatocyte ballooning,lobular inflammation,and steatosis),glycemic control and insulin resistance[including measurements of glycated hemoglobin(Hb A1C)and adipocytokines],lipid profile including free fatty acids,adipose distribution measured using magnetic resonance imaging(MRI),and thrombosis markers(platelet aggregation and plasminogen activator inhibitor 1 levels).We also sought to determine the correlation between changes in hepatic fat fraction(%)[as measured using the Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation(IDEAL)MRI technique]and changes in hepatic steatosis on liver biopsy.RESULTS Sitagliptin was not significantly better than placebo at reducing liver fibrosis score as measured on liver biopsy(mean difference between sitagliptin and placebo arms,0.40,P=0.82).There were no significant improvements evident with the use of sitagliptin vs placebo for the secondary histologic outcomes of NAS total score as well as for the individual components of NAS.Compared to baseline,those patients who received sitagliptin demonstrated improved Hb A1C(6.7%±0.4%vs 7.9%±1.0%,P=0.02),and trended towards improved adiponectin levels(4.7±3.5μg/m L vs 3.9±2.7μg/m L,P=0.06)and triglyceride levels(1.26±0.43 mmol/L vs 2.80±1.64 mmol/L,P=0.08).However,when compared with placebo,sitagliptin did not cause a statistically significant improvement in Hb A1C(mean difference,-0.7%,P=0.19)nor triglyceride levels(mean difference-1.10mmol/L,P=0.19)but did trend towards improved adiponectin levels only(mean difference,0.60μg/m L,P=0.095).No significant changes in anthropometrics,liver enzymes,other adipocytokines,lipid profile,thrombosis parameters,or adipose distribution were demonstrated.The MRI IDEAL procedure correlated well with steatosis scores obtained on liver biopsy in both groups at baseline and post-treatment,and the Spearman correlation coefficients ranged from r=0.819(baseline)to r=0.878(post-treatment),P=0.002.CONCLUSION Sitagliptin does not improve fibrosis score or NAS after 24 wk of therapy.The MRI IDEAL technique may be useful for non-invasive measurement of hepatic steatosis. | Tisha R Joy Charles A McKenzie Rommel G Tirona Kelly Summers Shannon Seney Subrata Chakrabarti Neel Malhotra Melanie D Beaton | 2017 | World Journal of Gastroenterology2017，23，1： | 18 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | An introduction to wavelet analysis in oceanography and meteorology: with application to the dispersion of Yannai waves显示文摘 | Meyers S D Kelly B G O'Brien J J | 1993 | Mon Wea Rev1993，121，10： | 2 |
| 4 | Genetics of myeloid leukemias显示文摘 | KELLY L M GILLILAND D G | 2002 | Annu Rev Genomics Hum Genet2002，3，： | 1 |
| 5 | Hydroxylated and methoxylated polybrorninated diphenyl ethers in a Canadian Arctic marine food web 显示文摘 | KELLY B C IKONOMOU M G BLAIR J D | 2008 | Environmental Science & Technolo- gy2008，42，19： | 1 |
| 6 | Adiponectin in re- lation to insulin sensitivity and insulin secretion in the develop- ment of type 2 diabetes: a prospective study in 64-year-old women显示文摘 | Fagerberg B Kellis D Bergstrom G | 2011 | J Intern Med2011，269，6： | 1 |
| 7 | Chain length dependence and sensing capabilities of the localized surface plasmon resonance of silver nanoparticles chemically modified with alkanethiol self-assembled monolayer显示文摘 | Malinsky M D Kelly K L Schatz G C | 2001 | Journal of the American Chemical Society2001，123，： | 1 |
| 8 | Data Mining for Fun and Prof it显示文摘 | Hand D J Blunt G Kelly M G | 2000 | Statistic Science2000，15，2： | 1 |
| 9 | Application of Fourier transform midinfrared spectroscopy to the discrimination between Irish artisanal honey and such honey adulterated with various sugar syrups显示文摘 | KELLY J D PETISCO C DOWNEY G | 2006 | Journal of agricultural and food chemistry2006，54，17： | 1 |
| 10 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 11 | The effect of fermented liquid feeding on the faecal microbiology and colostrum quality of farrowing sows 显示文摘 | Demeckova V Kelly D Coutts A G P | 2002 | International Food Microbiology2002，79，： | 1 |
| 12 | Selective reverse-reactivation of normal faults, and deformation around reverse-reactivated faults in the Mesozoic of the Somerset coast 显示文摘 | Kelly P G Peacock D C P Sanderson D J | 1999 | Journal of Structural Geology1999，21，： | 1 |
| 13 | Early nutrition and the development of immune function in the neonate显示文摘 | Kelly D A G Coutts | 2000 | Proc Nutr Soc2000，59，2： | 1 |
| 14 | PIagmn matrix metalloproteinase-9 and left ventricular remodeling after acute myocardial infarction in man:a prospective cohort study显示文摘 | Kelly D Cockerill G Ng U | 2007 | Eur Heart J2007，28，6： | 1 |
| 15 | Plasma matrix metallo- proteinase-9 and left ventricular remodelling after acute myocardial infarction in man: a prospective cohort study 显示文摘 | Kelly D Cockerill G Ng LL | 2007 | Eur Heart J2007，28，6： | 1 |
| 16 | Reactome: a database of reactions, pathways and biological processes 显示文摘 | Croft D O′Kelly G Wu G | 2010 | Nucleic Acids Res2010，39，： | 1 |
| 17 | Detection of honey adulteration by addition of fructose and glucose using near infrared transflectance spectroscopy显示文摘 | Downey G Fouratier V Kelly J D | 2003 | Journal of Near infrared spectroscopy2003，11，： | 1 |
| 18 | Geographical classification of honey samples by near-infrared spectroscopy:, a feasibility study 显示文摘 | Woodcock T Downey G Kelly J D | 2007 | Journal of Agriculture and Food Chemistry2007，55，： | 1 |
| 19 | Volatile fatty acid production on thermophilic aerobic digestion of sludge 显示文摘 | Chu A Mavinic D S Kelly H G | 1994 | Wat Res1994，28，7： | 1 |
| 20 | Circulating stromelysin-1(MMP-3):a novel predictor of LV dysfunction,remodelling and all-cause mortality after acute myocardial infarction显示文摘 | Kelly D Khan S Cockerill G | 2008 | Eur J Heart Fail2008，10，2： | 1 |
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