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| 1 | Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes显示文摘This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further research in this understudied malignancy. Pancreatic adenocarcinoma is a lethal condition with a rising incidence, predicted to become the second leading cause of cancer death in some regions. It often presents at an advanced stage, which contributes to poor five-year survival rates of 2%-9%, ranking firmly last amongst all cancer sites in terms of prognostic outcomes for patients. Better understanding of the risk factors and symptoms associated with this disease is essential to inform both health professionals and the general population of potential preventive and/or early detection measures. The identification of high-risk patients who could benefit from screening to detect pre-malignant conditions such as pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasms and mucinous cystic neoplasms is urgently required, however an acceptable screening test has yet to be identified. The management of pancreatic adenocarcinoma is evolving, with the introduction of new surgical techniques and medical therapies such as laparoscopic techniques and neo-adjuvant chemoradiotherapy, however this has only led to modest improvements in outcomes. The identification of novel biomarkers is desirable to move towards a precision medicine era, where pancreatic cancer therapy can be tailored to the individual patient, while unnecessary treatments that have negative consequences on quality of life could be prevented for others. Research efforts must also focus on the development of new agents and delivery systems. Overall, considerable progress is required to reduce the burden associated with pancreatic cancer. Recent, renewed efforts to fund large consortia and research into pancreatic adenocarcinoma are welcomed, but further streams will be necessary to facilitate the momentum needed to bring breakthroughs seen for other cancer sites. | Andrew McGuigan Paul Kelly Richard C Turkington Claire Jones Helen G Coleman R Stephen McCain | 2018 | World Journal of Gastroenterology2018，24，43： | 140 |
| 2 | CD40 is a cellular receptor mediating mycobacterial heat shock protein 70 stimulation of CC-chemokines 显示文摘 | Wang Y F Kelly C G Jaana T | 2001 | Immunity2001，15，6： | 1 |
| 3 | Hydroxylated and methoxylated polybrorninated diphenyl ethers in a Canadian Arctic marine food web 显示文摘 | KELLY B C IKONOMOU M G BLAIR J D | 2008 | Environmental Science & Technolo- gy2008，42，19： | 1 |
| 4 | Therapeutic Efficacy by Recombinant Human Granulocyte/Monocyte-Colony Stimulating Factor on Mucositis Occurring in Patients with Oral and Oropharynx Tumors Treated with Curative Radiotherapy显示文摘 | Masucci G Broman P Kelly C | | 0，，03： | 1 |
| 5 | Chain length dependence and sensing capabilities of the localized surface plasmon resonance of silver nanoparticles chemically modified with alkanethiol self-assembled monolayer显示文摘 | Malinsky M D Kelly K L Schatz G C | 2001 | Journal of the American Chemical Society2001，123，： | 1 |
| 6 | Stimulation of Th1-polarizing cytokines, C-C chemokines, maturation of dendritic cells, and adjuvant function by the peptide binding fragment of heat shock protein 70显示文摘 | Wang Y F Kelly C G Mahavir Singh | 2002 | J Immunol2002，169，5： | 1 |
| 7 | Application of Fourier transform midinfrared spectroscopy to the discrimination between Irish artisanal honey and such honey adulterated with various sugar syrups显示文摘 | KELLY J D PETISCO C DOWNEY G | 2006 | Journal of agricultural and food chemistry2006，54，17： | 1 |
| 8 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 9 | Selective reverse-reactivation of normal faults, and deformation around reverse-reactivated faults in the Mesozoic of the Somerset coast 显示文摘 | Kelly P G Peacock D C P Sanderson D J | 1999 | Journal of Structural Geology1999，21，： | 1 |
| 10 | Simultaneous follow-up of mouse colon lesions by colonoscopy and endoluminal ultrasound biomicroscopy显示文摘AIM:To evaluate the potential use of colonoscopy and endoluminal ultrasonic biomicroscopy(eUBM)to track the progression of mouse colonic lesions.METHODS:Ten mice were treated with a single azoxy-methane intraperitoneal injection(week 1)followed by seven days of a dextran sulfate sodium treatment in their drinking water(week 2)to induce inflammationassociated colon tumors.eUBM was performed simultaneously with colonoscopy at weeks 13,17-20 and21.A 3.6-F diameter 40 MHz mini-probe catheter was used for eUBM imaging.The ultrasound mini-probe catheter was inserted into the accessory channel of a pediatric flexible bronchofiberscope,allowing simultaneous acquisition of colonoscopic and eUBM images.During image acquisition,the mice were anesthetized with isoflurane and kept in a supine position over a stainless steel heated surgical waterbed at 37℃.Both eUBM and colonoscopic images were captured and stored when a lesion was detected by colonoscopy or when the eUBM image revealed a modified colon wall anatomy.During the procedure,the colon was irrigated with water that was injected through a flush port on the mini-probe catheter and that acted as the ultrasound coupling medium between the transducer and the colon wall.Once the acquisition of the last eUBM/colonoscopy section for each animal was completed,the colons were fixed,paraffin-embedded,and stained with hematoxylin and eosin.Colon images acquired at the first time-point for each mouse were compared with subsequent eUBM/colonoscopic images of the same sites obtained in the following acquisitions to evaluate lesion progression.RESULTS:All 10 mice had eUBM and colonoscopic images acquired at week 13(the first time-point).Two animals died immediately after the first imaging acquisition and,consequently,only 8 mice were subjected to the second eUBM/colonoscopy imaging acquisition(at the second time-point).Due to the advanced stage of colonic tumorigenesis,5 animals died after the second time-point image acquisition,and thus,only three were subjected to the third eUBM/colonoscopy imaging acquisition(the third time-point).eUBM was able to detect the four layers in healthy segments of colon:the mucosa(the first hyperechoic layer moving away from the mini-probe axis),followed by the muscularis mucosae(hypoechoic),the submucosa(the second hyperechoic layer)and the muscularis externa(the second hypoechoic layer).Hypoechoic regions between the mucosa and the muscularis externa layers represented lymphoid infiltrates,as confirmed by the corresponding histological images.Pedunculated tumors were represented by hyperechoic masses in the mucosa layer.Among the lesions that decreased in size between the first and third time-points,one of the lesions changed from a mucosal hyperplasia with ulceration at the top to a mucosal hyperplasia with lymphoid infiltrate and,finally,to small signs of mucosal hyperplasia and lymphoid infiltrate.In this case,while lesion regression and modification were observable in the eUBM images,colonoscopy was only able to detect the lesion at the first and second time-points,without the capacity to demonstrate the presence of lymphoid infiltrate.Regarding the lesions that increased in size,one of them started as a small elevation in the mucosa layer and progressed to a pedunculated tumor.In this case,while eUBM imaging revealed the lesion at the first time-point,colonoscopy was only able to detect it at the second time-point.All colonic lesions(tumors,lymphoid infiltrate and mucosal thickening)were identified by eUBM,while colonoscopy identified just76%of them.Colonoscopy identified all of the colonic tumors but failed to diagnose lymphoid infiltrates and increased mucosal thickness and failed to differentiate lymphoid infiltrates from small adenomas.During the observation period,most of the lesions(approximately67%)increased in size,approximately 14%remained unchanged,and 19%regressed.CONCLUSION:Combining eUBM with colonoscopy improves the diagnosis and the follow-up of mouse colonic lesions,adding transmural assessment of the bowel wall. | Rossana C Soletti Kelly Z Alves Marcelo AP de Britto Dyanna G de Matos Mnica Soldan Helena L Borges Joo C Machado | 2013 | World Journal of Gastroenterology2013，19，44： | 1 |
| 11 | Effect of friction fatigue on pile capacity in dense sand显示文摘 | Gavin Kenneth G O'Kelly Brendan C | 2007 | Journal of Geotechnical and Geo-environmental Engineering2007，133，1： | 1 |
| 12 | Effect of monomeric and polymeric co-solutes on cetyltrimethylammonium bromide wormlike micelles:Rheology,Cryo-TEM and Small-angle neutron scattering显示文摘 | Kelly R.Francisco Marcelo A.da Silva Edvaldo Sabadini G(a)ran Karlsson Cécile A.Dreiss | | 0，，： | 1 |
| 13 | Effect ofpH on intracellular accumulation of trace concentrations of Hg(Ⅱ) in Escherichia coli under anaerobic conditions, as measured using a mer-lux bioreporter 显示文摘 | Golding G R Sparling R Kelly C A | 2008 | Applied and Environmental Microbiology2008，74，3： | 1 |
| 14 | Oxalobaeter formigenes may reduce the risk of calcium oxalate kidney stones 显示文摘 | KAUFMAN D W KELLY J P CURHAN G C | 2008 | J Am Soe Nephrol2008，19，6： | 1 |
| 15 | CCR5 inhibition prevents cardiac dysfunction in the SIV/Macaque model of HIV显示文摘 | Kelly K M Tocchetti C G Lyashkov A | 2014 | JAm Heart Assoc2014，3，00： | 1 |
| 16 | Bioaccumulation behavionr of polybrominated diphenyl ethers(PBDEs) in a Canadian Arctic marine food web显示文摘 | KELLY B C IKONOMOU M G BLAIR J D | 2008 | Science of the Total Environment2008，401，： | 1 |
| 17 | Occluded solution chemistry control and the role of alloy sulfur on the initiation of crevice corrosion in type 304ss显示文摘 | Brossia C S Kelly R G | 1998 | Corrosion Science1998，40，： | 1 |
| 18 | Occluded Solution Chemistry Control and the Role of Alloy Sulfur on the Initiation of Crevice Corrosion in Type 304ss显示文摘 | Brossia C S Kelly R G | 1998 | Corrosion Science1998，40，11： | 1 |
| 19 | Nickel(II)-ca talysed oxidative guanine and DNA damage beyond 8- oxoguanine 显示文摘 | Kelly M C Whitaker G White B | 2007 | Free Radic Biol Med2007，42，： | 1 |
| 20 | Malignant transformation of oral lichen planus显示文摘 | Rajentheran R McLean N R Kelly C G | 1999 | Eur J Surg Oncol1999，25，： | 1 |
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