|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cancer immune checkpoint blockade therapy and its associated autoimmune cardiotoxicity显示文摘有免疫力的检查点分子在进化被出现由激活的 T 房间保护主人免受自我攻击的伤害。然而,癌症房间熬过并且膨胀的策略,能劫持这些分子和机制压制 T 调停房间的有免疫力的回答。因此,堵住检查点分子提高宿主免疫系统的反肿瘤活动的一个想法被开发了并且在禁止的 T 细胞合作受体的发现以后适用于癌症治疗,细胞毒素的T淋巴细胞联系了蛋白质 4 ( CTLA-4 ),并且进一步在 PD-1 和它的 ligands 的鉴定上提高了。自从 2010,几个检查点禁止者被食物及药品管理局同意了,许多更多在临床的试用。在先进癌症的治疗,这些禁止者显著地增加了反应率和幸存好处。然而,与惹人注目的结果伴随了,广泛地发生在许多机关的免疫者相关的不利事件(irAEs ) 被观察并且报导,其中一些是致命的。此处,我们首先在癌症治疗在有免疫力的检查点分子的研究和他们的堵住的抗体的应用程序考察最近的前进,然后讨论治疗和策略导致到监视器的心脏的毒性,当它发生时,管理这个不利事件。 | Jiu-cheng Zhang Wei-dong Chen Jean Bustamante Alvarez Kelly Jia Lei Shi Qiang Wang Ning Zou Kai He Hua Zhu | 2018 | Acta Pharmacologica Sinica2018，39，11： | 14 |
| 2 | An appraisal of lymph node ratio in colon and rectal cancer: not one size fits all显示文摘 | M. Medani Niall Kelly George Samaha G. Duff Vourneen Healy Elizabeth Mulcahy Eoghan Condon David Waldron Jean Saunders J. Calvin Coffey | 2013 | International Journal of Colorectal Disease2013，，10： | 1 |
| 3 | Mitochondrial Polymorphisms Significantly Reduce the Risk of Parkinson Disease显示文摘 | Joelle M. van der Walt Kristin K. Nicodemus Eden R. Martin William K. Scott Martha A. Nance Ray L. Watts Jean P. Hubble Jonathan L. Haines William C. Koller Kelly Lyons Rajesh Pahwa Matthew B. Stern Amy Colcher Bradley C. Hiner Joseph Jankovic William G. | 2003 | The American Journal of Human Genetics2003，，4： | 1 |
| 4 | Oxygen isotopic composition of soil water: Quantifying evaporation and transpiration显示文摘 | Jean C.C Hsieh Oliver A Chadwick Eugene F Kelly Samuel M Savin | 1998 | Geoderma1998，，1： | 1 |
| 5 | Outcome After Curative Resection for Locally Recurrent Rectal Cancer显示文摘 | Isabelle Bedrosian M.D. Geoffrey Giacco M.S. Lee Pederson M.D. Miguel A. Rodriguez-Bigas M.D. Barry Feig M.D. Kelly K. Hunt M.D. Lee Ellis M.D. Steven A. Curley M.D. Jean Nicolas Vauthey M.D. Marc Delclos M.D. Christopher H. Crane M.D. Nora Janjan M.D. Jo | 2006 | Diseases of the Colon & Rectum2006，，2： | 1 |
| 6 | Redefing paracoccus denitrificans and Paracoccus pantotrophus and the case for a reassessment of the strains held by international culture collections 显示文摘 | Donovan P Kelly Jean P Euzeby Celia F Goodhew | 2006 | International Journal of systematic and evolutionary microbiology2006，56，： | 1 |
| 7 | Strategic intent and performance: The role of resource allocation decisions显示文摘 | Babu John Mariadoss Jean L. Johnson Kelly D. Martin | 2014 | Journal of Business Research2014，，： | 1 |
| 8 | First case of bioterrorism-related inhalational anthrax, florida, 2001: North Carolina investigation 显示文摘 | Jean MM Marc F Kelly TM | 2002 | Emerg Infect Dis2002，8，： | 1 |
| 9 | Feasibility of Breast Preservation in the Treatment of Occult Primary Carcinoma Presenting With Axillary Metastases显示文摘 | Georges Vlastos MD Marina E. Jean MD Attiqa N. Mirza MD Nadeem Q. Mirza MD MPH Henry M. Kuerer MD PhD Frederick C. Ames MD Kelly K. Hunt MD Merrick I. Ross MD Thomas A. Buchholz MD Aman U. Buzdar MD S. Eva Singletary MD | 2001 | Annals of Surgical Oncology2001，，5： | 1 |
| 10 | Feasibility of Breast Preservation in the Treatment of Occult Primary Carcinoma Presenting With Axillary Metastases显示文摘 | Georges Vlastos MD Marina E. Jean MD Attiqa N. Mirza MD Nadeem Q. Mirza MD MPH Henry M. Kuerer MD PhD Frederick C. Ames MD Kelly K. Hunt MD Merrick I. Ross MD Thomas A. Buchholz MD Aman U. Buzdar MD S. Eva Singletary MD | 2001 | Annals of Surgical Oncology2001，，5： | 1 |
| 11 | Linking the spatiotemporal variation of litterfall to standing vegetation biomass in Brazilian savannas显示文摘全球尺度上的凋落物受气候,土壤特征和植被结构的影响,随着植被现存生物量的增加,从草地到森林的凋落物产量增加。然而,在景观尺度上,凋落物的产量与植被结构之间的相同关系却很少被研究,相邻的结构不同的群落之间凋落物格局的比较研究也比较缺乏。本研究使用一种标准化的方法来描述四种稀树草原地貌之间的结构差异,并分析了在巴西塞拉多保护区(Cerrado)中地貌与凋落物变化的关系。我们评估了平均分布在4个地貌的48个地点的木本植被结构和组成,并从2014年4月到2015年3月每月监测凋落物产量。研究结果表明,不同地貌的木本植被密度、断面积、柱状体积和地上生物量各不相同。地上生物量与年凋落物产量之间存在着很强的正相关关系,凋落物产量随植被结构的增加从0.9增加到8.4 Mg ha^(−1)。不同植被类型间的月产量具有季节性和相似性,旱季产量增加。叶组成显性部分(约85%)和凋落物的季节性主要是由于干旱月份落叶集中所致。然而,可能是随着植物群落中落叶物种丰度的减少,全年凋落物的时间格局显示出从开放植被类型到封闭植被类型的季节性逐渐减少。我们的研究结果表明,植被结构的变化可能会影响不同地貌凋落物的空间和时间分布格局,这些格局在整个塞拉多保护区景观中同时发生,可能对该生态系统的整体功能产生影响。此外,这些发现强调了使用标准化方法是正确比较不同环境中凋落物格局的必要条件。 | Alan N.Costa Jeane R.Souza Karyne M.Alves Anderson Penna-Oliveira Geisciele Paula-Silva Ingrid S.Becker Kelly Marinho-Vieira Ana L.Bonfim Alessandra Bartimachi Ernane H.M.Vieira-Neto | 2020 | Journal of Plant Ecology2020，13，5： | 0 |
| 12 | Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic显示文摘Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were reported.The study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar declines.Methods We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke centres.Patients with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,codes.The 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May 2020.The prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal variation.Findings There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,p<0.0001).Embolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative drop.Subgroup analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,p<0.0001).A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this tertile.Interpretation There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 pandemic.These findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction. | Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sugimura Masaaki Uno Yohei Takenobu Yuji Matsumaru Satoshi Yamada Ryuhei Kono Takuya Kanamaru Masafumi Morimoto Junichi Iida Vasu Saini Dileep Yavagal Saif Bushnaq Wenguo Huang Italo Linfante Jawad Kirmani David S Liebeskind Viktor Szeder Ruchir Shah Thomas G Devlin Lee Birnbaum Jun Luo Anchalee Churojana Hesham E Masoud Carlos Ynigo Lopez Brendan Steinfort Alice Ma Ameer E Hassan Amal Al Hashmi Mollie McDermott Maxim Mokin Alex Chebl Odysseas Kargiotis Georgios Tsivgoulis Jane G Morris Clifford J Eskey Jesse Thon Leticia Rebello Dorothea Altschul Oriana Cornett Varsha Singh Jeyaraj Pandian Anirudh Kulkarni Pablo M Lavados Veronica V Olavarria Kenichi Todo Yuki Yamamoto Gisele Sampaio Silva Serdar Geyik Jasmine Johann Sumeet Multani Artem Kaliaev Kazutaka Sonoda Hiroyuki Hashimoto Adel Alhazzani David Y Chung Stephan A Mayer Johanna T Fifi Michael D Hill Hao Zhang Zhengzhou Yuan Xianjin Shang Alicia C Castonguay Rishi Gupta Tudor G Jovin Jean Raymond Osama O Zaidat Raul G Nogueira SVIN COVID-19 Registry,the Middle East North Africa Stroke and Interventional Neurotherapies Organization(MENA-SINO),Japanese Society of Vascular and Interventional Neurology Society(JVIN) | 2021 | Stroke & Vascular Neurology2021，6，4： | 0 |
| 13 | The impact of the coronavirus disease 2019 pandemic on physical activity in U.S. children显示文摘Background:Daily moderate-to-vigorous physical activity(MVPA)is vital to the physical,mental,and social well-being of children.Early restrictions during the coronavirus disease 2019(COVID-19)pandemic included the closure of schools and physical activity(PA)amenities across the US.This study aimed to examine the impact of the pandemic on the PA and play behavior of U.S.children and to provide evidencebased recommendations to improve their PA.Methods:A cross-sectional,online,parent-reported survey was conducted of children aged 318 years between April and June 2020 to assess light PA and MVPA using a modified Godin Leisure-Time Exercise Questionnaire.Additional items included family/child socioeconomic demographics,child adaptability to the pandemic,and community access.The survey was shared through social media and snowball sampling distribution.Results:Analysis of 1310 surveys indicated child PA scores declined significantly during the pandemic(from 56.6 to 44.6,max 119,p<0.001).Specifically,MVPA score decreased(from 46.7 to 34.7,max 98,p<0.001)while light PA remained the same.Age-based changes were seen in the quantity,variety,and intensity of PA,with the lowest pandemic-related impact seen in preschoolers and the highest in high schoolers(4.7 vs.17.2,p<0.001).Community-based peer PA decreased across all age groups.Conclusion:This study shows decreased PA levels in U.S.children,according to parent reporting,during the COVID-19 pandemic.Recommendations for community leaders,educators,and parents to improve PA in children are provided.With continued spread of COVID-19,these results and recommendations may be imperative to the physical well-being of U.S.children. | Kirsten Tulchin-Francis Wilshaw Stevens Jr Xiangli Gu Tao Zhang Heather Roberts Jean Keller Dana Dempsey Justine Borchard Kelly Jeans Jonathan VanPelt | 2021 | Journal of Sport and Health Science2021，10，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员