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| 1 | 在血压控制不良的高血压患者中使用数字化干预的家庭和在线血压管理:随机对照试验显示文摘HOME BP试验(The home and online management and evaluation of blood pressure)的目的是评估在初级预防中结合自我监测和自我管理的数字化干预在高血压管理中的作用。研究者纳入英国76个治疗中心经过治疗但血压控制不好(>140/90 mm Hg, 1 mm Hg=0.133 kPa)并能上网的患者622例,进行自动确定主要终点的公开随机对照试验。 | McMa-nus RJ Little P Stuart B Morton K Raftery J Kelly J Bradbury K Zhang J Zhu S Murray E May CR Mair FS Michie S Smith P Band R Ogburn E AllenJ Rice C Nut-tall J Williams B Yardley L 陈嘉睿(译) 叶鹏(审校) | 2021 | 中华高血压杂志2021，29，5： | 15 |
| 2 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 3 | WONCA研究论文摘要汇编——全科医疗问诊中占主导地位的非语言交流的简单干预随机控制试验显示文摘背景改变问诊中非语言行为的影响并不明朗。目的评估占问诊主导地位的非语言交流的简短医生培训。设计和场所进行整群随机平行组试验,在南安普敦市研究协调中心附近的全科医疗诊所中选取年龄≥16岁的全科医生。方法 16名全科医生随机分为培训组和非培训组,培训包括对一项前期行为研究结果的简短介绍〔研究结果的缩略词为KEPe Warm,含义如下:展现对患者的了解;鼓励(例如说"嗯"来发出反馈信号)〕;肢体参与(碰触、手势、稍稍前倾);预热:冷静/专业的开场,预热,避免疏远和问诊结束时的非言语收场和鼓励医生对问诊录像进行回顾。以医学访问满意量表(MISS)项目平均得分(1~7分)和患者对交流其他方面的认知为试验指标。结果培训组MISS整体得分高于非培训组〔OR=0.23,95%CI(0.06,0.41)〕;其中,痛苦减轻、关系认知分量表的得分提高最多;交流/合作认知得分〔OR=0.29,95%CI(0.09,0.49)〕和健康提升得分〔OR=0.26,95%CI(0.05,0.46)〕显著提高,私人关系认知、积极方法和了解疾病对生活影响的得分提高不显著。结论占问诊主导地位的非语言交流的简短医生培训和问诊录像回顾能够提升患者满意度、减轻痛苦、促进合作方法认知和健康提升。 | Little P White P Kelly J 本刊编辑部 | 2015 | 中国全科医学2015，18，21： | 2 |
| 4 | Characterization Study of Diamond and Diamond-like Carbon显示文摘 | Dowling D P Ahern M J Kelly T C | 1992 | Surface and Coating Technology1992，53，： | 2 |
| 5 | Magnetron sputtering;a review of recent development and applications显示文摘 | Kelly P J Arnell R D | 2000 | Vacuum2000，56，： | 1 |
| 6 | 显示文摘 | Kelly P J Arnell R D | 2000 | Vacuum2000，56，： | 1 |
| 7 | Unmetabolized folic acid in serum : acute studies in subjects consuming fortified food and supple- ments 显示文摘 | Kelly P McPartlin J Gogglns M | 1997 | Am J Clin Nun''1997，65，： | 1 |
| 8 | Polyelectrolytes as in- clusions in electrorheologically active materials: Effect of chemical characteristics on ER actirity materials and mecha- nisms in electrorheology显示文摘 | BLOCK H KELLY J P QIN A | 1990 | Langmuir1990，6，： | 1 |
| 9 | Influence of transglutaminase treatment on properties of micellar casein and products made therefrom 显示文摘 | Mounsey J S O ' Kennedy B T Kelly P M | 2005 | Lait2005，85，： | 1 |
| 10 | A low-glycemic index diet combined with exercise reduces insulin resistance,postprandial hyperinsulinemia,and glucose-dependent insulinotropic polypeptide responses in obese,prediabetichumans显示文摘 | Solomon T P Haus J M Kelly K R | 2010 | Am J Clin Nutr2010，92，6： | 1 |
| 11 | Robust analysis of the yeast proteome under 50 kDa by molecular-massbased fractionation and top-down mass spectrometry显示文摘 | Kellie J F Catherman A D Durbin K R Tran J C Tipton J D Norris J L Witkowski C E 2nd Thomas P M Kelleher N L | | 0，，01： | 1 |
| 12 | Magnetron SputterDg:a Review of Recent Developments and Applications显示文摘 | Kelly P J Amell R D | | 0，，03： | 1 |
| 13 | Modelling tourism destination energyconsumption and greenhouse gas emissions: Whistler, BritishColumbia, Canada显示文摘 | Kelly J Williams P W | 2007 | Journal of Sustainable Tourism2007，15，1： | 1 |
| 14 | Light-emitting fluorine photoreactive liquid crystals for organic electroluminescence显示文摘 | Aldred M P Eastwood A J Kelly S M | 2004 | Chem Mater2004，16，： | 1 |
| 15 | Late paleocene to eocene paleocenography of the equatorial pacific ocean: stable isotopes recorded at ocean drilling program site 865, allison guyot显示文摘 | Zachos J C Thomas E Parrow M Paul C K Kelly D C Silva I P Sliter W V Lohmann K C | 1995 | Paleoceanography1995，10，： | 1 |
| 16 | Magnetron Sputtering:A Review ofRecent Developments and Applications显示文摘 | Kelly P J Arnell R D | 2000 | Vacuum2000，56，3： | 1 |
| 17 | The Characterization ofOxotremorine induced Hypothermic Response in the Rat 显示文摘 | Ryan P M Kelly J P Chambers P L | 1996 | Pharmacol Toxicol1996，79，5： | 1 |
| 18 | 查看详情显示文摘 | Regan S P Marozas J A Craxton R S Kelly J H Donaldson W R Jaanimagi P A Jacobs-Perkins D Keck R L Kessler T J Mey-erhofer D D Sangster T C Seka W Smalyuk V A Sknpsky S Zuegel J D | | 0，，： | 1 |
| 19 | Influence of varied parking tariffs on parking occupancy levels by trip purpose显示文摘 | Kelly J A Clinch J P | 2006 | Transport Policy2006，13，6： | 1 |
| 20 | Formanilide and carbanilide from aniline and carbon dioxide 显示文摘 | Munshi Pradip Heldebrant David J McKoon Erin P Kelly Patrick A Tai Chih-Cheng Jessop Philip G | 2003 | Tetrahedron Letters2003，44，： | 1 |
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