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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Characterization Study of Diamond and Diamond-like Carbon显示文摘 | Dowling D P Ahern M J Kelly T C | 1992 | Surface and Coating Technology1992，53，： | 2 |
| 3 | Influence of transglutaminase treatment on properties of micellar casein and products made therefrom 显示文摘 | Mounsey J S O ' Kennedy B T Kelly P M | 2005 | Lait2005，85，： | 1 |
| 4 | A low-glycemic index diet combined with exercise reduces insulin resistance,postprandial hyperinsulinemia,and glucose-dependent insulinotropic polypeptide responses in obese,prediabetichumans显示文摘 | Solomon T P Haus J M Kelly K R | 2010 | Am J Clin Nutr2010，92，6： | 1 |
| 5 | Late paleocene to eocene paleocenography of the equatorial pacific ocean: stable isotopes recorded at ocean drilling program site 865, allison guyot显示文摘 | Zachos J C Thomas E Parrow M Paul C K Kelly D C Silva I P Sliter W V Lohmann K C | 1995 | Paleoceanography1995，10，： | 1 |
| 6 | Effect of lactation on the de- cline of brush border lactase activity in neonatal pigs 显示文摘 | KELLY D KING T P MCFADYEN M | 1991 | Gut1991，32，： | 1 |
| 7 | 查看详情显示文摘 | Regan S P Marozas J A Craxton R S Kelly J H Donaldson W R Jaanimagi P A Jacobs-Perkins D Keck R L Kessler T J Mey-erhofer D D Sangster T C Seka W Smalyuk V A Sknpsky S Zuegel J D | | 0，，： | 1 |
| 8 | Fibreoptie endoscopic evaluation of swallowing and videofluomscopy: does examination type influence perception of pharyngeal residue severity? 显示文摘 | Kelly AM Leslie P Beale T | 2006 | Clin Otolaryngo12006，31，5： | 1 |
| 9 | Classification comparisons between dual-pol,compact polarimetric and quad-pol SAR imagery显示文摘 | Ainsworth T L Kelly J P Lee J S | 2009 | ISPRS Journal of Photogrammetry and Remote Sensing2009，64，5： | 1 |
| 10 | Characterization study of diamond and diamond-like carbon显示文摘 | Dowling D P Ahern M J Kelly T C | 1992 | Surface and Coatings Technology1992，53，： | 1 |
| 11 | Wheat (Triticum Aestivum) and Rotational Crop Response to MON 37500显示文摘 | KELLY J P PEEPER T F | 2003 | Weed Technology2003，17，1： | 1 |
| 12 | Effect of Elevated Temperature Exposure on Cast Gamma Titanium Aluminide (Ti-48Al-2Cr-2Nb) 显示文摘 | Kelly T J Austin C M Fink P J | 1994 | Scripta Metallurgica et Materialia1994，30，9： | 1 |
| 13 | Diffusion MRI in ischemic stroke compared to pathologically verified infarction显示文摘 | Kelly P J Hedley-Whyte E T Primavera J | 2001 | Neurology2001，56，7： | 1 |
| 14 | Slow responses to standard dose rituximab in immune thrombocytopenic purpura显示文摘 | KELLY K GLEESON M MURPHY P T | 2009 | Haematologica2009，94，： | 1 |
| 15 | Fibreoptic endoscopic evalua-tion of swallowing and videofluoroscopy : Does examination typeinfluence perception of pharyngeal residue severity? 显示文摘 | Kelly AM Leslie P Beale T | 2006 | ClinOtolaryngol2006，31，42： | 1 |
| 16 | Identifying, understanding, and analyzing critical infrastructure interdependencies 显示文摘 | RINALDI S M PEERENBOOM J P KELLY T K | 2001 | IEEE Control Systems Magazine2001，21，6： | 1 |
| 17 | Effect of low oxygen and temperature on quality retention of 'Bing' cherries during prolonged storage显示文摘 | CHEN P M MELLENTHIN W M KELLY S B FACTEAU T J | 1981 | J Amer Soe Hort Sci1981，106，： | 1 |
| 18 | The use of cast Ti48Al-2Cr-2Nb in jet engines显示文摘 | Barrett J Kelly T | 1997 | JOM1997，49，： | 1 |
| 19 | Extension of pheno type associated with structural mutations in type I collagen: siblings with juvenile osteoporosis have an alpha2(I)Gly436→Arg substitution显示文摘 | Dawson P A Kelly T E Marini J C | 1999 | J Bone Miner Res1999，14，： | 1 |
| 20 | Slow responses to standard dose rituximab in immune thrombocytopenic purpura显示文摘 | Kelly K Gleeson M Murphy P T | 2009 | Haematologica2009，94，3： | 1 |
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