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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 3 | Hypertension subtype and risk of cardiovascular disease in chinese adults显示文摘 | KELLY T N GU D CHEN j | 2008 | Circula- tion2008，118，15： | 1 |
| 4 | WholeObody MRI incomparison to skeletal scintigraphy in detection of skeletal-metastases in patients with solid tumors 显示文摘 | Ghanem N Altehoefer C Kelly T | 2006 | In Vivo2006，20，1： | 1 |
| 5 | Chemical inhibition of nitrification in activated sludge显示文摘 | Kelly R T Henriques I D S Love N G | 2004 | Biotechnol Bioeng2004，85，6： | 1 |
| 6 | Metallurgy of high strength Ni Mn microsystems fabricated by electrodeposition显示文摘 | Yang N Y C Headley T J Kelly J J | 2004 | Scripta Materialia2004，51，： | 1 |
| 7 | Metallurgy of high strength Ni-Mn microsystems fabricated显示文摘 | YANG N Y C HEADLEY T J KELLY J J | 2004 | Scripta Materialia2004，51，： | 1 |
| 8 | Rationally designed,chiral Lewis acid for the asymmetric induction of some Diels-Alder reactions显示文摘 | Kelly T R Whiting A Chandrakumar N S | 1986 | J Am Chem Soc1986，108，12： | 1 |
| 9 | In situ sulphate stimulation of mercury methylation in a boreal peat?land: Toward a link between acid rain and methylmercury contamination in remote environments显示文摘 | Branfireun B A Roulet N T Kelly C A Rudd J W M | 1999 | Global Biogeo?chem Cy1999，13，3： | 1 |
| 10 | Whole-body MRI in com- parison to skeletal scintigraphy in detection of skeletal metastases in patiens with solid tumors显示文摘 | Ghanem N Altehoefer C Kelly T | 2006 | In Vivo2006，20，1： | 1 |
| 11 | Autonomous driving in urban environments: Boss and the urban challenge 显示文摘 | URMSON C ANHALT J BAGNELL D BAKER C BITTNER R CLARK M N DOLAN J DUGGINS D GALATALI T GEYER C GITTLEMAN M HARBAUGH S HEBERT M HOWARD T M KOLSKI S KELLY A LIKHACHEV M MCNAUGHTON M MILLER N PETERSON K PILNICK B RAJKUMAR R RYBSKI P SALESKY B SEO Y W SINGH S SNIDER J STENTZ A WHITTAKER W WOLKOWICKI Z Z1GLAR J BAE H BROWN T DEMITRISH D LITKOUHI B NICKOLAOU J SADEKAR V ZHANG Wen-de STRUBLE J TAYLOR M DARMS M FERGUSON D | 2008 | Journal of Field Robotics2008，25，8： | 1 |
| 12 | Metallurgy of high strength Ni- Mn microsystems fabricated by electrodeposition 显示文摘 | Yang N Y C Headley T J Kelly J J | 2004 | Scripta Materialia2004，51，： | 1 |
| 13 | In situ sulphate stimulation of mercury methylation in a boreal peatland: Toward a link between acid rain and methylmercury contamination in remote environments 显示文摘 | Branfireun B A Roulet N T Kelly C A | 1999 | Global Biogeochemical Cycles1999，13，3： | 1 |
| 14 | Solar photovohaic charging of lithium-ion batteries显示文摘 | GIBSON T L KELLY N A | 2010 | Journal of Power Sources2010，195，12： | 1 |
| 15 | Lead coprecipitation with iron oxyhydroxide nano-particles显示文摘 | LU P NUHFER N T KELLY S | 2011 | Geochimica et Cosmochimica Acta2011，75，16： | 1 |
| 16 | Serum nouron-specific enolase as a predictor of intracranial lesions in children with head trauma:a pilot stody显示文摘 | Fridriksson T Kini N Walsh Kelly C | 2000 | Acad Emerg Med2000，7，7： | 1 |
| 17 | How to study proteins by circular dichroism 显示文摘 | Kelly S M Jess T J Price N C | 2005 | Biochim Biophys Acta2005，1751，2： | 1 |
| 18 | Photocatalytic growth and plasmon resonance-assisted photoelectrochemical toppling of upright Ag nanoplates on a nanoparticulate TiO2 film显示文摘 | ICHIRO T KAZUKI M STACEY D S EMIKO K LANCE KELLY K SAKAIA N TATSUMA T | 2009 | Chem Commun2009，，： | 1 |
| 19 | How to study proteins by circular dichroism 显示文摘 | Kelly S M Jess T J Price N C | 2005 | Biochimica et Biophysica Acta (BBA)-Proteins & Proteomics2005，1751，2： | 1 |
| 20 | Chemical inhibition of nitrification in activated sludge显示文摘 | Kelly II R T Henriques I D S Love N G | 2004 | Biotechnol Bioeng2004，85，： | 1 |
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