4篇
您的检索式：作者名="Ken MACKIE"
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| 1 | The utility of megavoltage computed tomography images from a helical tomotherapy system for setup verification purposes显示文摘 | Lisa J. Forrest Thomas Rockwell Mackie Ken Ruchala Michelle Turek Jeff Kapatoes Hazim Jaradat Susanta Hui John Balog David M. Vail Minesh P. Mehta | 2004 | International Journal of Radiation Oncology Biology Physics2004，，5： | 1 |
| 2 | Cannabinoid receptors and endocannabinoids: Evidence for new players显示文摘 | Ken Mackie Nephi Stella | 2006 | The AAPS Journal2006，，： | 1 |
| 3 | 大麻酚类受体-1在脊髓、背角、背根神经节和周围神经的分布(英文)显示文摘AIM: The localization of CB1 receptors in the spinalcord, spinal roots, dorsal root ganglion (DRG), andperipheral nerve of the rat was determined.METHODS: We studied the distribution of CB1cannabinoid receptors by immunohistochemistry usingan antibody raised against the N-termina1 of thereceptor. RESULTS: The spinal cord showednumerous transverse fibers labelled for CB1 receptorsthroughout and concentrated in the dorsal horn.Lightly-stained cells were observed throughout thespinal cord gray matter. The DRG also showed cellsand fibers labelled for CB1 receptors. Labelled fiberswere observed in both dorsal and ventral roots as well | M Clara.SANUDO-PENA Nicole M STRANGMAN Ken MACKIE J Mchael WALKER TSOU Kang | 1999 | 中国药理学报1999，20，12： | 0 |
| 4 | Engineering human spinal microphysiological systems to model opioid-induced tolerance显示文摘pioids are commonly used for treating chronic pain.However,with continued use,they may induce tolerance and/or hyperalgesia,which limits therapeutic efficacy.The human mechanisms of opioid-induced tolerance and hyperalgesia are significantly understudied,in part,because current models cannot fully recapitulate human pathology.Here,we engineered novel human spinal microphysiological systems(MPSs)integrated with plug-and-play neural activity sensing for modeling human nociception and opioid-induced tolerance.Each spinal MPS consists of a flattened human spinal cord organoid derived from human stem cells and a 3D printed organoid holder device for plug-and-play neural activity measurement.We found that the flattened organoid design of MPSs not only reduces hypoxia and necrosis in the organoids,but also promotes their neuron maturation,neural activity,and functional development.We further demonstrated that prolonged opioid exposure resulted in neurochemical correlates of opioid tolerance and hyperalgesia,as measured by altered neural activity,and downregulation ofμ-opioid receptor expression of human spinal MPSs.The MPSs are scalable,cost-effective,easy-to-use,and compatible with commonly-used well-plates,thus allowing plug-and-play measurements of neural activity.We believe the MPSs hold a promising translational potential for studying human pain etiology,screening new treatments,and validating novel therapeutics for human pain medicine. | Hongwei Cai Zheng Ao Chunhui Tian Zhuhao Wu Connor Kaurich Zi Chen Mingxia Gu Andrea G.Hohmann Ken Mackie Feng Guo | 2023 | Bioactive Materials2023，，4： | 0 |
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