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| 1 | Medium-term results of permanent sacral nerve stimulation for faecal incontinence 显示文摘 | KENEFICK N J VAIZEY C J COHEN R G | 2002 | Br J Surg2002，89，： | 1 |
| 2 | Non-surgical management of fecal incontinence 显示文摘 | CHEETHAM M J KENEFICK N J KAMM M A | 2001 | Hosp Med2001，62，： | 1 |
| 3 | Injectable silicone biomaterial for fecal incontinence duo to internal anal sphincter dysfunction 显示文摘 | KENEFICK N J WAIZEY C J MALOUF A J | 2002 | Gut2002，51，： | 1 |
| 4 | A prospective evaluation of stapled haemorrhoidopexy/rectal mucosectomy in the management of 3rd and 4th degree hemorrhoids显示文摘 | SLAWIK S KENEFICK N GREENSLADE G L | 2007 | Colorectal Dis2007，9，4： | 1 |
| 5 | A prospective evalua- tion of stapled heamorrhoidopexy/rectal mucosectomy in the management of 3rd and 4th degree haemorrhoids显示文摘 | Slawik S Kenefick N Greenslade GL | 2007 | Colorec- tal Dis2007，9，4： | 1 |
| 6 | Effect of heat acclimation on sweat minerals 显示文摘 | CHTNEVERE T D KENEFICK R W CHEUVRONT S N etal | 2008 | Med SciSports Exe2008，40，5： | 1 |
| 7 | Double-blind placebo- controlled crossover study of sacral nerve stimulation for idiopathic constipation 显示文摘 | Kenefick N J Vaizey C J Cohen C R | 2002 | Br J Surg2002，89，12： | 1 |
| 8 | Treatment of resistanlanal fissure with advancement anoplasty显示文摘 | KENEFICK N J GEE A S DURDEY P | 2002 | Colorectal Dis2002，4，6： | 1 |
| 9 | Biological and analytical variation of the human sweating re-sponse: implications for study design and analysis 显示文摘 | KENEFICK R W CHEUVRONT S N ELLIOTT L at | 2012 | Am jPhys Regul Integr Comp Phys2012，302，2： | 1 |
| 10 | Double-blind placebo-controlled crossover study of sacral nerve stimulation for idiopathic constipation 显示文摘 | Kenefick N J Vaizey C J Cohen CR | 2002 | Br J Surg2002，89，12： | 1 |
| 11 | Biological and analytical variation of the human sweating response:implications for study design and analysis显示文摘 | KENEFICK R W CHEUVRONT S N ELLIOTT L D | 2012 | Am J Phy Regul Integr Comp Phy2012，302，2： | 1 |
| 12 | A prospective evaluation of stapled heamorrhoidopexy/rectal mucosectomy in themanagement of 3rd and 4th degree haemorrhoids显示文摘 | Slawik S Kenefick N Greenslade GL | 2007 | Colorectal Dis2007，9，4： | 1 |
| 13 | A prospective evaluation of stapled heamorr-hoidopexy rectal mucosectomy in the management of 3rd and 4th degree haemor Thoids显示文摘 | Slawik S Kenefick N Greenslade GL | 2007 | Colorectal Dis2007，9，4： | 1 |
| 14 | Effect of heat acclimation on sweat minerals显示文摘 | Chinevere T D Kenefick R W Cheuvront S N | 2008 | Medicine & Science in Sports & Exercise2008，40，5： | 1 |
| 15 | Effectiveness of an amino acid beverage formulation in diarrheapredominant irritable bowel syndrome:A pragmatic real-world study显示文摘BACKGROUND Amino-acid based medical foods have shown promise in alleviating symptoms of drug induced gastrointestinal side effects;particularly,diarrhea-predominant symptoms.Irritable bowel syndrome(IBS)is a gastrointestinal disorder that affects up to 9% of people globally,with diarrhea predominant IBS(IBS-D)being the most prevalent subtype.Further trials are needed to explore potential added benefits when integrated into standard care for IBS-D.AIM To assess the effectiveness of an amino acid-based medical food as an adjunct to standard of care for adults with IBS-D.METHODS This is a pragmatic,real world,open label,single arm study comparing a 2-week baseline assessment to a 2-week intervention period.One hundred adults,aged 18 to 65 years,with IBS-D,according to Rome IV criteria,were enrolled after completing a 2-week baseline assessment period and received a 2-week supply of an amino acid based medical food which was consumed at home twice daily on top of their standard of care.The primary outcome was an assessment of tolerability after 2-weeks of consumption,while secondary outcomes included changes in stool consistency(Bristol Stool Form Scale),severity of abdominal pain&discomfort,symptoms of urgency,Global Improvement Survey(GIS),and the IBS severity scoring system(IBS-SSS).RESULTS The test product was well-tolerated as each participant successfully completed the full 14-day trial,and there were no instances of dropouts or discontinuation of the study product reported.Forty percent of participants achieved a 50% or more reduction in the number of days with type 6-7 bowel movements(IBS-D stool consistency responders).Fifty-three percent of participants achieved a clinically meaningful reduction of 30% in mean weekly pain scores,and 55%experienced the same for mean weekly discomfort scores(IBS-D pain and discomfort responders).Participants experienced a mean-109.4(95% confidence interval:-130.1,-88.8)point reduction on the IBS-SSS and 52% experienced a minimally clinically important difference of>95 points.An IBS-SSS category shift from severe to moderate or mild occurred in 69% of participants.For functional symptoms,76% of participants reported symptom relief on the GIS.CONCLUSION The amino acid-based medical food was well-tolerated,when added to the standard of care,and demonstrated improvements in both overall IBS symptom severity and IBS-D symptoms within just 2 wk. | Samantha E Niles Phil Blazy Samuel N Cheuvront Robert W Kenefick Sadasivan Vidyasagar Adam BSmith Neil Fawkes William Denman | 2023 | World Journal of Gastrointestinal Pharmacology and Therapeutics2023，14，5： | 0 |
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