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| 1 | MicroRNA-21 as a potential colon and rectal cancer biomarker显示文摘Colorectal cancer(CRC)is one of the most common malignant diseases worldwide and the prognosis is still poor although much progress has been achieved in recent years.In order to reduce CRC-related deaths,many studies are aimed at identifying novel screeningand prognosis-related biomarkers.MicroRNAs(miRNAs)are a class of 18-27-nucleotide single-stranded RNA molecules that regulate gene expression at the posttranscriptional level.It has been demonstrated that miRNAs regulate a variety of physiological functions,including development,cell differentiation,proliferation,and apoptosis.They play important roles in various physiologic and developmental processes and in the initiation and progression of various human cancers.It has been shown that miRNAs can critically regulate tumor cell gene expression,and evidence suggests that they may function as both oncogenes and tumor suppressor genes.In CRC,miRNAs-21 is one of the most important miRNAs and is rapidly emerging as a novel biomarker in CRC,with good potential as a diagnostic and therapeutic target.In this review,we summarize the latest research findings of the clinicopathological relevance of miRNAs-21 in CRC initiation,development,and progress,highlighting its potential diagnostic,prognostic,and therapeutic application,as well as discuss-ing future prospects. | Tao Li Mei Ha Leong Bruce Harms Gregory Kennedy Lin Chen | 2013 | World Journal of Gastroenterology2013，19，34： | 16 |
| 2 | Efficacy of intravitreal bevacizumab for stage 3+retinopathy of prematurity显示文摘 | Mintz-Hittner HA Kennedy KA Chuang AZ | | 0，，： | 1 |
| 3 | Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity显示文摘 | Mintz-Hittner HA Kennedy KA Chuang AZ | 2011 | N Engl J Med2011，364，7： | 1 |
| 4 | Botulinum A toxin injection as a treatment for blepharospasm 显示文摘 | Scott AB Kennedy RA Stubbs HA | 1985 | Arch Ophthal1985，103，： | 1 |
| 5 | Effica- cy of intravitreal bevaeizumab for stage 3+ retinopathy of prematurity显示文摘 | Mintz-Hittner HA Kennedy KA Chuang AZ | 2011 | N Engl J Med2011，364，7： | 1 |
| 6 | Botulinum A toxic injection as a treatment for blepharospasm显示文摘 | SCOTT AB KENNEDY RA STUBBS HA | 1985 | Arch Ophthalmol1985，103，： | 1 |
| 7 | Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity显示文摘 | Mintz-Hittner HA Kennedy KA Chuang AZ | 2011 | N Engl J Med2011，364，7： | 1 |
| 8 | Efficacy of intravitreal bevacizumab for stage 3 + retinopathy of prematuri- ty显示文摘 | Mintz-Hittner HA Kennedy KA Chuang AZ | 2011 | N Engl J Med2011，364，7： | 1 |
| 9 | Botulinum A toxic injection as atreatment for blepharespasm显示文摘 | Scott AB Kennedy RA Stubbs HA | 1985 | Arch Ophthalmol1985，103，： | 1 |
| 10 | Efficacy of intravitrealbevacizumab for stage 3+retinopathy of prematurity显示文摘 | Mintz-Hittner HA Kennedy KA Chuang AZ | 2011 | N Engl J Med2011，364，7： | 1 |
| 11 | A prospective analysis of the HOMA model:the Mexico City Diabetes Study显示文摘 | Ha finer SM Kennedy E Gonzalez C | 1996 | Diabetes Care1996，19，10： | 1 |
| 12 | Collateral u- rethral duplication in the frontal plane : a spectrum of cases 显示文摘 | Kennedy HA Steidle CP Mitchell ME | 1988 | J Urol1988，139，2： | 1 |
| 13 | Efficacy of intravit- real bevacizumab for stage 3 + retinopathy of prematurity显示文摘 | Mintz-Hittner HA Kennedy KA Chuang AZ | 2011 | N Engl J Med2011，364，7： | 1 |
| 14 | Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes 显示文摘 | Slanden CL Kennedy NJ Flavell HA Davis RJ | 2009 | Mol Cell Biol2009，29，17： | 1 |
| 15 | Efficacy of in- travitreal bevacizumab for stage 3^+ retinopathy of prematurity显示文摘 | Mintz-Hittner HA Kennedy KA Chuang AZ | 2011 | N Engl J Med2011，364，7： | 1 |
| 16 | Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity显示文摘 | Mintz-Hittner HA Kennedy KA Chuang AZ | 2011 | N Engl J Med2011，364，7： | 1 |
| 17 | Botulinum toxin A injection as a treatment for blepharospasm显示文摘 | Scott AB Kennedy RA Stubbs HA | 1985 | Arch Ophthal1985，103，： | 1 |
| 18 | Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity显示文摘 | Mintz-Hitmer HA Kennedy KA Chuang AZ | 2011 | NEnglJ Med2011，364，7： | 1 |
| 19 | Efficacy of intravitreal bevacizumab for stage 3 + retinopathy of prematurity显示文摘 | Mintz-Hittner HA Kennedy KA Chuang AZ | 2011 | N Engl J Med2011，364，7： | 1 |
| 20 | Deep repeti- tive transcranial magnetic stimulation associated with im- proved social functioning in a young woman with an au- tism spectrum disorder显示文摘 | Enticott PG Kennedy HA Zangen A | 2011 | J ECT2011，27，1： | 1 |
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