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| 1 | Chemopreventive effect of oltipraz on AFB_1-induced hepatocarcinogenesis in tree shrew model显示文摘INTRODUCTIONHepatocellular carcinoma (HCC) is one of themajor cancers in the world with a mortality of morethan 250 000 cases yearly.More than 137 000 casesof HCC were diagnosed each year in China,whichacount approximately for more than 40 percent ofthe total number in the world.HCC has become thesecond major cause of death for cancer in | TW Kensler BD Roebuck | 2000 | World Journal of Gastroenterology2000，6，5： | 5 |
| 2 | Keap1 eye on the target:chemoprevention of liver cancer显示文摘Hepatocellular 癌(HCC ) 是世界范围的最普通的癌症之一,每年引起将近 600 000 死亡。 HCC 的增加的风险为许多指向 HBV 感染的 thesedeaths.Prevention 策略由于有肝炎 B 病毒( HBV )和到饮食的黄麴毒素的暴露的长期的感染负责,黄麴毒素暴露能戏剧性地影响程序在某 high-riskareas.Strategies 开始了在店有的食物减少黄麴毒素污染的 HCC.Universal HBV 种痘的率另外 beenimplemented.However ,黄麴毒素污染的完全的消除可能不是可能的。为这个原因,改变黄麴毒素布置的 chemoprevention 策略是一座实际策略岩山引出在有高饮食的黄麴毒素暴露的人口的 HCC 的发生。机制导致 ofaflatoxin 的 hepatocarcinogenesis 是众所周知的。这知识为暴露的评估提供基础给黄麴毒素布置 bychemopreventive 代理人的黄麴毒素,以及调整。象另外的代谢物一样的黄麴毒素 DNA 损坏和毒性的产品能被用作简历标记评估黄麴毒素布置的调整。黄麴毒素布置的调整能通过结合和 cytoprotective 酶的正式就职被完成。许多通过 Kelch 联系 ECH 蛋白质 1 这些酶被调整(Keap1 )-NF-E2-related factor2 (Nrf2 )-antioxi-dant 反应元素() 发信号,为 chemoprevention.Rodent 研究使这条小径成为一个重要分子的目标识别了导致 cytoprotective 基因的 chemopreventive 代理人的几个班。这些 inducers 包括酉分的抗氧化剂, dithiolethiones, isothiocyanates,和 triterpenoids.Furthermore,临床的干预证明了 Keap1-Nrf2-ARE 发信号的 inducers 增加 cytoprotective 酶表示,导致黄麴毒素的调整布置。要做以便在 at-riskpopulations.However 从现出症状之前的潜的评估带有希望的 chemopreventive 代理人去申请的许多工作遗体,适当地设计的临床的试用将帮助这进程,它能在 HCC 的发生上有深刻影响。 | Melinda Sue YATES Thomas Wells KENSLER | 2007 | Acta Pharmacologica Sinica2007，28，9： | 2 |
| 3 | Nrf2 as a target for cancer chemoprevention显示文摘 | Xiang Yu Thomas Kensler | 2005 | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis2005，，1： | 2 |
| 4 | Genetic mutations associated with cigarette smoking in pancreatic cancer显示文摘 | Blackford A Parmigiani G Kensler TW | 2009 | Cancer Res2009，69，： | 1 |
| 5 | Nrf2 : friend or foe for chemopreven- tion显示文摘 | Kensler TW Wakabayashi N | 2010 | Carcinogenesis2010，31，： | 1 |
| 6 | Oltipraz: clinical opportunities for cancer chemoprevention显示文摘 | Kensler T W Helzlsouer K J etal | 1995 | p J Cell Biochem Suppl1995，22，： | 1 |
| 7 | Chemoprevention through the Keapl Nrf2 signaling pathway by phase 2 enzyme inducers显示文摘 | Kwak MK Wakabayashi N Kensler TW | 2004 | Mutation Res2004，555，12： | 1 |
| 8 | Biomarkers and mechanistic approaches in environmental epidemiology 显示文摘 | Links JM Kensler TW Groopman JD | 1995 | Ann Rev Public Health1995，16，： | 1 |
| 9 | Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates 显示文摘 | Zhang Y Kensler T W Cho C G | 1994 | Proceeding of the National Academy of Sciences of the United States of America1994，91，8： | 1 |
| 10 | Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway显示文摘 | Kensler TW Wakabayashi N Biswal S | 2007 | Annu Rev Pharmacol Toxicol2007，47，： | 1 |
| 11 | Nrf2 as a target for cancer chemoprevention 显示文摘 | Yu X Kensler T | 2005 | Mutation Research/fundamental &Molecular Mechanisms of Mutagenesis2005，591，591： | 1 |
| 12 | Cell survival responses to environmental stresses via the Keapl - Nrf2 - ARE pathway显示文摘 | KENSLER T W WAKABAYASHI N BISWAL S | 2007 | Annu Rev Pharmaeol Toxieol2007，47，： | 1 |
| 13 | Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway显示文摘 | Kensler TW Wakabayashi N Biswal S | | 0，，： | 1 |
| 14 | Cell survival responses to environmental stresses via the Keap 1-Nrf2-ARE pathway显示文摘 | Kensler TW Wakabayashi N Biswal S | 2007 | Annu Rev Pharmacol Toxicol2007，47，： | 1 |
| 15 | Oxidative Mechanisms in Carcinogenesis 显示文摘 | Guyton K Z Kensler T W | 1993 | Br Med Bull1993，49，3： | 1 |
| 16 | Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates显示文摘 | Zhang Y Kensler TW Cho CG | 1994 | Proc Natl Acad Sci USA1994，91，： | 1 |
| 17 | Repetitive training of isolated movements improves the outcome of motor rehabilitation of the centrally paretic hand显示文摘 | Butefisch C Hummelsheim H Kensler P | 1995 | J Neurol Sci1995，130，： | 1 |
| 18 | Changing rates for liver and lung cancers in Qidong,china显示文摘 | Chen JG Kensler TW | 2014 | Chem Res Toxicol2014，27，1： | 1 |
| 19 | Anticarcinogenic Activities of Sulforaphane and Structurally Related Synthetic Norbomyl Isothiocyanates显示文摘 | Zhang Y S Kensler T W Cho C G Posner G H Talalay P | 1994 | P Natl Acad Sci USA1994，91，： | 1 |
| 20 | Translational strategies for canc?er prevention in liver显示文摘 | Kensler T W Qian G S ChenJ G | 2003 | Nat Rev Cancer2003，3，5： | 1 |
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