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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 3 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 4 | Numerical simulations of smoke movement from a pool fire in a ventilated tunnel显示文摘 | Flecher D F Kent J H Apte V B | 1994 | Fire SafJ1994，23，3： | 3 |
| 5 | Molecular targets in the treatment of anxiety显示文摘 | Kent J M Mathew S J Gorman J M | 2002 | Biol Psychiatry2002，52，10： | 2 |
| 6 | Utilization of a benchtop mass spectrometer with capillary supercritical fluid chromatography显示文摘 | MURUGAVERL B KENT J DE LUCA V S J | 1993 | Journal of Chromatography A1993，633，： | 1 |
| 7 | Genetic vaccination strategies for enhanced cellular, humoral and mucosal immunity显示文摘 | Ramsay A J Kent S J Strugnell R A | 1999 | Immunol Rev1999，171，1： | 1 |
| 8 | Commutation failures in HVDC transmission systems显示文摘 | Thio C V Davies J B Kent K L | 1996 | IEEE Trans on Power Delivery1996，11，2： | 1 |
| 9 | Performance Appraisals: Usage, Criteria and Obserbations显示文摘 | Pettijohn L S Stephen Parker R Pettijohn C E Kent J L | 2001 | Journal of Management Development2001，20，9： | 1 |
| 10 | Tumor size predicts survival within stage IA non-small cell lung cancer 显示文摘 | Port JL Kent MS Korst R J | 2003 | Chest2003，124，5： | 1 |
| 11 | Memory At- tack on Device-Independent Quantum Cryp- tography显示文摘 | BARRETT J COLBECK R KENT A | 2013 | Physical Review Letters2013，110，01： | 1 |
| 12 | The state of the art of thezebrafish model for toxicology and toxicologic patholo- gy research-Advantages and current limitations 显示文摘 | Spitsbergen J M Kent M L | 2003 | Toxicology Pathology2003，，： | 1 |
| 13 | Developing a Logistics Service Quality Scale显示文摘 | Mentzer J T Flint D J Kent J L | | 0，，01： | 1 |
| 14 | Commutation Failures in HVDC Transmission Systems显示文摘 | THIO C V DAVIES J B KENT K L | | 0，，02： | 1 |
| 15 | An exploratory investigation of responses elicited by music varying in tempo, tonality, and texture显示文摘 | Kellaris 1 J Kent R J | 1993 | Journal of Consumer Psychology1993，2，4： | 1 |
| 16 | Mycobacteriosis in zebrafish ( Danio rerio ) research facilities 显示文摘 | Kent M L Whipps C M Matthews J L | 2004 | Comparative Biochemistry and Physiology Part C2004，138，： | 1 |
| 17 | Interactions between terminally substituted amino acids in an aqueous and a non-aqueous environment显示文摘 | Lilley T H Milburn P J | 1985 | J Soln Chem1985，14，： | 1 |
| 18 | Commutation failures in HVDC transmission systems显示文摘 | Thio C V Davies J B Kent K L | 1996 | IEEE Trans on Power Delivery1996，11，2： | 1 |
| 19 | Environmentally induced foregut remodeling by PHA-4 / FoxA and DAF-12 / NHR显示文摘 | AO W GAUDET J KENT W J | 2004 | Science2004，305，： | 1 |
| 20 | BLAT-the BLAST-like alignment tool显示文摘 | KENT W J | | 0，，： | 1 |
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