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| 1 | Successful treatment of warfarin-induced skin necrosis using oral rivaroxaban: A case report显示文摘BACKGROUND Heparin is commonly recommended for warfarin-induced skin necrosis;however, there is currently no established therapy for this disease. We present a serious case of warfarin-induced skin necrosis that was successfully treated with oral rivaroxaban, a factor Xa inhibitor.CASE SUMMARY A 48-year-old woman was admitted to the hospital for cellulitis of the right lower extremity. After antibiotic treatment, she developed pain and swelling of the left lower extremity, and deep vein thrombosis of both lower extremities was diagnosed. She was treated with a continuous heparin injection;subsequently,oral warfarin was concomitantly administered. Heparin was terminated after the therapeutic range was reached. On the following day, the patient had swelling and pain in the left lower extremity. In addition to decrease in protein S activity due to systemic lupus erythematosus, warfarin also reduced protein C activity,resulting in further hypercoagulation and skin necrosis. Warfarin was discontinued, and continuous heparin injection was resumed. Although the patient had to undergo amputation of the distal end of her left foot, continuous heparin injection was switched to oral rivaroxaban, and she was eventually discharged from the hospital in remission.CONCLUSION Administration of direct oral anticoagulants instead of warfarin is important in patients with decreased protein S and C activity. | Momoka Kamada Tsuneaki Kenzaka | 2019 | World Journal of Clinical Cases2019，7，24： | 5 |
| 2 | Serum matrix metalloproteinase 3 in detecting remitting seronegative symmetrical synovitis with pitting edema syndrome: A case report显示文摘We report a case of remitting seronegative symmetrical synovitis with pitting edema(RS3 PE) syndrome in a 71-year-old woman. She referred to our hospital with finger stiffness, edema of both hands and feet, pain of bilateral shoulder, wrist, metacarpophalangeal, proximal interphalangeal, and ankle joints. Rheumatoid factor was negative, human leukocyte antigen-B7 antigen was positive. Moreover, matrix metalloproteinase 3(MMP-3) was high. She was diagnosed with RS3 PE syndrome, and treatment with prednisolone(15 mg/d) was started. One week after prednisolone treatment initiation, CRP decreased to negative, and joint pain was almost completely resolved. However, hand stiffness persisted, and MMP-3 level was still high. Thus, prednisolone dose was increased to 20 mg/d, and the stiffness resolved. Twenty days after treatment initiation, MMP-3 was normalized. MMP-3 was more indicative of RS3 PE syndrome symptoms than CRP. Thus, MMP-3 seems to be more sensitive to RS3 PE syndrome symptoms. | Tsuneaki Kenzaka Ken Goda | 2018 | World Journal of Clinical Cases2018，6，5： | 4 |
| 3 | Clinically mild encephalitis/encephalopathy with a reversible splenial lesion caused by methicillin-sensitive Staphylococcus aureus bacteremia with toxic shock syndrome: a case report显示文摘 | Kosaim K Kenzaka T Sagara Y | 2016 | BMC Infect Dis2016，16，1： | 1 |
| 4 | Purple urine bag syndrome in a patient witha urethral balloon catheter and a history of ileal conduit urinarydiversion显示文摘 | Kenzaka T | 2015 | Korean J Intern Med2015，30，3： | 1 |
| 5 | Detection of bacteria carrying the stx2 gene by in situ loop-mediated isothermal amplification显示文摘 | Maruyama F Kenzaka T Yamaguchi N | 2003 | Applied and Environmental Microbiology2003，69，8： | 1 |
| 6 | High-frequency phage-mediated gene transfer among Escherichia coil cells,determined at the single-cell level显示文摘 | Kenzaka T Tani K Sakotani A | 2007 | Appl Environ Microbiol2007，73，10： | 1 |
| 7 | Detection of bacteria carrying the stx2 gene by in situ loop-mediated isothermal amplification显示文摘 | Maruyama F Kenzaka T Yamaguchi N | 2003 | Appl Environ Microbiol2003，69，8： | 1 |
| 8 | Detection of Bacteria Carrying the stx2 Gene by In Situ Loop- Mediated Isothernal Amplication显示文摘 | Marnyama F Kenzaka T Yamaguchi N | 2003 | Applied and Environmental Microbiology2003，69，8： | 1 |
| 9 | Use of a semi quantitative procalcitonin kit for evaluating severity and predicting mortality in patients with sepsis 显示文摘 | Kenzaka T Okayama M Kuroki S | 2012 | Int J Gen Med2012，5，： | 1 |
| 10 | Detection of bacteria caring the stx2 gene by in situ loop-mediated isothermal amplification 显示文摘 | Maruyama F Kenzaka T Yamaguchi N | 2003 | Appl Environ Microbiol2003，69，8： | 1 |
| 11 | Use of a semiquantitative procalcitonin kit for evaluating severity and predicting mortality in patients with sepsis 显示文摘 | Kenzaka T Okayama M Kuroki S etal | 2012 | Int J Gen Med2012，5，： | 1 |
| 12 | Top of the basilar syndrome with disturbed consciousness显示文摘 | Kenzaka T Onishi T | 2015 | Mayo Clin Proc2015，90，1： | 1 |
| 13 | Detection of bacteriacarrying the stx2 gene by in situ loop-mediated isothermal amplification 显示文摘 | MAMYAMA F KENZAKA T YAM-AGUCHI N | 2003 | Appl Environ Microbiol2003，69，8： | 1 |
| 14 | Detection of bacteria carrying the stx2 gene by in situ loop-mediatedi sothermal amplification显示文摘 | Maruyama F Kenzaka T Yamaguchi N | | 0，，08： | 1 |
| 15 | A case of subacute infective endocarditis and blood access infection caused by Enterococcus durans 显示文摘 | Kenzaka T Takamura N Kumabe A | 2013 | BMC Infect Dis2013，13，1： | 1 |
| 16 | Computed Tomography Images of Rhabdomyolysis显示文摘 | Tsuneaki Kenzaka Koichi Takida | 2013 | Intern Med J2013，52，： | 1 |
| 17 | Detection of bacteria carrying the stX2 gene by in situ loop-mediated isothermal amplification显示文摘 | Maruyama F Kenzaka T YamaguchiN | | 0，，8： | 1 |
| 18 | Detection of bacteria carrying the stx2 gene by insituloop - mediated isothermal amplification 显示文摘 | Maruyama F Kenzaka T Yamaguchi N | 2003 | Appl Environ Microbiol2003，69，8： | 1 |
| 19 | Detection of Bacteria Carrying the stx2 Gene by In Situ Loop-Mediated Isothermal显示文摘 | Marnyama F Kenzaka T Yamaguehi N | 2003 | Applied and Environmental Microbiology2003，69，8： | 1 |
| 20 | Detection of bacteria carrying the stx2 gene by in situ loop-mediated isothermal amplification显示文摘 | Maruyama F Kenzaka T Yamaguchi N | 2003 | Appl Environ Microbiol2003，69，8： | 1 |
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