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| 1 | Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis显示文摘AIM To investigate the effects of orally gavaged aqueous rhubarb extract(RE) on 5-fluorouracil(5-FU)-induced intestinal mucositis in rats. METHODS Female Dark Agouti rats(n = 8/group) were gavaged daily(1 mL) with water, high-dose RE(HDR; 200 mg/kg) or low-dose RE(LDR; 20mg/kg) for eight days. Intestinal mucositis was induced(day 5) with 5-FU(150 mg/kg) via intraperitoneal injection. Intestinal tissue samples were collected for myeloperoxidase(MPO) activity and histological examination. Xenopus oocytes expressing aquaporin 4 water channels were prepared to examine the effect of aqueous RE on cell volume, indicating a potential mechanism responsible for modulating net fluid absorption and secretion in the gastrointestinal tract. Statistical significance was assumed at P < 0.05 by one-way ANOVA. RESULTS B o d y w e i g h t w a s s i g n i f i c a n t l y r e d u c e d i n r a t s administered 5-FU compared to healthy controls(P < 0.01). Rats administered 5-FU significantly increased intestinal MPO levels(≥ 307%; P < 0.001), compared to healthy controls. However, LDR attenuated this effect in 5-FU treated rats, significantly decreasing ileal MPO activity(by 45%; P < 0.05), as compared to 5-FU controls. 5-FU significantly reduced intestinal mucosal thickness(by ≥ 29% P < 0.001) as compared to healthy controls. LDR significantly increased ileal mucosal thickness in 5-FU treated rats(19%; P < 0.05) relative to 5-FU controls. In xenopus oocytes expressing AQP4 water channels, RE selectively blocked water influx into the cell, induced by a decrease in external osmotic pressure. As water efflux was unaltered by the presence of extracellular RE, the directional flow of water across the epithelial barrier, in the presence of extracellular RE, indicated that RE may alleviate water loss across the epithelial barrier and promote intestinal health in chemotherapy-induced intestinal mucositis.CONCLUSION In summary, low dose RE improves selected parameters of mucosal integrity and reduces ileal inflammation, manifesting from 5-FU-induced intestinal mucositis. | Juliana E Bajic Georgina L Eden Lorrinne S Lampton Ker Y Cheah Kerry A Lymn Jinxin V Pei Andrea J Yool Gordon S Howarth | 2016 | World Journal of Gastroenterology2016，22，37： | 3 |
| 2 | FUSARIUM-ID v. 1.0: A DNA Sequence Database for Identifying Fusarium显示文摘 | David M. Geiser María del Mar Jiménez-Gasco Seogchan Kang Izabela Makalowska Narayanan Veeraraghavan Todd J. Ward Ning Zhang Gretchen A. Kuldau Kerry O’donnell | 2004 | European Journal of Plant Pathology (-)2004，，5： | 2 |
| 3 | Farmer Participatory Evaluation of Nursery Bed Treatments for the Control of Root-Knot Nematodes [Meloidogynejavanica (Treub) Chitwood and Meloidogyne incognita (Kofoid and White) Chitwood] in Smallholder Farms in Kenya显示文摘 | D. K. Karanja S. R. Gowen B. Ndung u R. O. Musebe S. Simons A McLeod B. R. Kerry P. K. Karanja B. Pembroke | 2011 | Journal of Agricultural Science and Technology(A)2011，1，5： | 2 |
| 4 | Correlation of VEGF production with IL - 1α and IL - 6 secretion by human pituitary adenoma cells 显示文摘 | BORG S A KERRY K E ROYDS J A | 2005 | European Journal of Endocrinology2005，152，： | 1 |
| 5 | Changes in the microbiological and physicochemical quality of high-pressure-treated oysters ( Crassostrea gigas ) during chilled storage 显示文摘 | Cruz-Romero M Kerry J Kelly A | 2008 | Food Control2008，19，12： | 1 |
| 6 | Do statins reduce blood pressure? A meta-analysis of randomized, controlled trims 显示文摘 | STRAZZULLO P KERRY S M BARBATO A | 2007 | Hypertension2007，49，4： | 1 |
| 7 | Marine natural product as anticancer drugs显示文摘 | Simmons T L Eric A Kerry M | 2005 | Mol Cancer Ther2005，4，2： | 1 |
| 8 | The importance of the host plant on the interaction of root knot nematodes and the nematophous fungus, Verticillium chlamydosporium Goddard 显示文摘 | Bourne J M Kerry B R Leij de F A A M | 1996 | Biocontrol Science Biology1996，6，： | 1 |
| 9 | Do statins reduce blood pressure? A meta-analysis of randomized, controlled trials 显示文摘 | Strazzullo P Kerry SM Barbato A | 2007 | Hypertension2007，49，4： | 1 |
| 10 | Effects of high-pressure and heat treatments on physical and biochemicalcharacteristics of oysters (Crassostrea gigas)显示文摘 | Cruz-Romero M Kelly A L Kerry J P | 2007 | InnovativeFood Science and Emerging Technologies2007，，8： | 1 |
| 11 | Comparing sampling needs for variograms of soil properties computed by the method of moments and residual maximum likelihood显示文摘 | Kerry R Oliver M A | 2007 | Geoderma2007，140，4： | 1 |
| 12 | Do statins reduce blood pressure?A meta-analysis of randomized,controlled trials显示文摘 | Strazzullo P Kerry SM Barbato A | 2007 | Hypertension2007，49，4： | 1 |
| 13 | Fatty acids, volatile compounds and colour changes in high-pressure-treated oysters ( Crassostrea gigas ) 显示文摘 | CRUZ-ROMERO M C KERRY J P KELLY A L | 2008 | Innovat Food Sci Emerg Tech2008，9，1： | 1 |
| 14 | Influence of HPP conditions on selected beef quality attributes and their stability during chilled storage 显示文摘 | McArdle R A Marcos B Kerry J P | 2011 | Meat Science2011，87，3： | 1 |
| 15 | The rheological properties of exudates from cured porcine muscle: effects of added carrageenans and whey protein conentrate/carrageenan blends显示文摘 | KERRY J F MORRISSEY P A BUCKLEY D J | 1999 | J Sci Food Agric1999，79，： | 1 |
| 16 | Fatty acids, volatile compounds and colour changes in high-pressure-treated oysters Innovative显示文摘 | Cruz-Romero M C Kerry J P Kelly A L | 2008 | Innov Food Sci Emerg2008，9，1： | 1 |
| 17 | The rheological properties of exudates from cured porcine muscle: effects of added polysaccharides and whey protein/polysaccharide blends显示文摘 | KERRY J F MORRISSEY P A BUCKLEY D J | 1999 | J Sci Food Agric1999，79，： | 1 |
| 18 | Effects of highpressure and heat treatments on physical and biochemical characteristics of oysters (Crassostrea gig as)显示文摘 | Cruz-Romero M Kelly A L Kerry J P | 2007 | Innovative Food Science & Emerging Technologies2007，8，1： | 1 |
| 19 | Physical assessment of composite biodegradable films manufactured using whey protein isolate, gelatin and sodium alginate显示文摘 | WANG Lizhe AUTY M A P KERRY J P | 2010 | Journal of Food Engineering2010，96，2： | 1 |
| 20 | High pressure processing of Australian navel orange juices: sensory analysis and volatile flavor profiling显示文摘 | IRENE A B KERRY E KATHERINE S | 2005 | Innovative Food Science and Emerging Technologies2005，，6： | 1 |
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