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| 1 | Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis显示文摘AIM To investigate the effects of orally gavaged aqueous rhubarb extract(RE) on 5-fluorouracil(5-FU)-induced intestinal mucositis in rats. METHODS Female Dark Agouti rats(n = 8/group) were gavaged daily(1 mL) with water, high-dose RE(HDR; 200 mg/kg) or low-dose RE(LDR; 20mg/kg) for eight days. Intestinal mucositis was induced(day 5) with 5-FU(150 mg/kg) via intraperitoneal injection. Intestinal tissue samples were collected for myeloperoxidase(MPO) activity and histological examination. Xenopus oocytes expressing aquaporin 4 water channels were prepared to examine the effect of aqueous RE on cell volume, indicating a potential mechanism responsible for modulating net fluid absorption and secretion in the gastrointestinal tract. Statistical significance was assumed at P < 0.05 by one-way ANOVA. RESULTS B o d y w e i g h t w a s s i g n i f i c a n t l y r e d u c e d i n r a t s administered 5-FU compared to healthy controls(P < 0.01). Rats administered 5-FU significantly increased intestinal MPO levels(≥ 307%; P < 0.001), compared to healthy controls. However, LDR attenuated this effect in 5-FU treated rats, significantly decreasing ileal MPO activity(by 45%; P < 0.05), as compared to 5-FU controls. 5-FU significantly reduced intestinal mucosal thickness(by ≥ 29% P < 0.001) as compared to healthy controls. LDR significantly increased ileal mucosal thickness in 5-FU treated rats(19%; P < 0.05) relative to 5-FU controls. In xenopus oocytes expressing AQP4 water channels, RE selectively blocked water influx into the cell, induced by a decrease in external osmotic pressure. As water efflux was unaltered by the presence of extracellular RE, the directional flow of water across the epithelial barrier, in the presence of extracellular RE, indicated that RE may alleviate water loss across the epithelial barrier and promote intestinal health in chemotherapy-induced intestinal mucositis.CONCLUSION In summary, low dose RE improves selected parameters of mucosal integrity and reduces ileal inflammation, manifesting from 5-FU-induced intestinal mucositis. | Juliana E Bajic Georgina L Eden Lorrinne S Lampton Ker Y Cheah Kerry A Lymn Jinxin V Pei Andrea J Yool Gordon S Howarth | 2016 | World Journal of Gastroenterology2016，22，37： | 3 |
| 2 | Correlation of VEGF production with IL - 1α and IL - 6 secretion by human pituitary adenoma cells 显示文摘 | BORG S A KERRY K E ROYDS J A | 2005 | European Journal of Endocrinology2005，152，： | 1 |
| 3 | TMS1,a novel pro-apoptotic caspase recruitment domain protein,is a target ofmethylation-induced gene silencing in human breast cancers显示文摘 | Kerry E C Beth/M Claire E B | 2000 | Cancer Res2000，60，22： | 1 |
| 4 | Characterization of proteolysis during the ripening of semi-dry fermented sausages显示文摘 | HUGHES M KERRY J ARENDT E | 2002 | Meat Science2002，62，2： | 1 |
| 5 | Probes for measuring the thermal conductivity of granular materials显示文摘 | Goldsmith H J Kerrie E D Papazian V | 1981 | J Phys E: Sci Instrum1981，，14： | 1 |
| 6 | Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic states: a possible explanation for impaired collateral formation in cardiac tissue显示文摘 | Chou E Suzuma I Kerrie JW | | Circulation0，，： | 1 |
| 7 | Characterization of proteolysis during the ripening of semi-dry fermented sausages显示文摘 | Hughes M C Kerry J P Arendt E K | 2002 | Meat Science2002，62，： | 1 |
| 8 | High pressure processing of Australian navel orange juices: sensory analysis and volatile flavor profiling显示文摘 | IRENE A B KERRY E KATHERINE S | 2005 | Innovative Food Science and Emerging Technologies2005，，6： | 1 |
| 9 | Increasing destructiveness of tropical cyclones over the past 30 years显示文摘 | Kerry E | 2005 | Nature2005，436，4： | 1 |
| 10 | Role of replication and CpG methylation in fragile X syndrome CGG Deletions in primate cells显示文摘 | Kerrie N E Michelle R L Christopher E P | 2005 | Am Hum Genet2005，76，： | 1 |
| 11 | Characterization of proteolysis during the ripening of senti-dry fermented sausages显示文摘 | Hughes M C Kerry J P Arendt E K | 2002 | Meat Science2002，62，2： | 1 |
| 12 | On the extension of CP models to address cathodic protection under a delaminated coating显示文摘 | Kerry N A Mark E O | 2009 | Corrosion Science2009，51，5： | 1 |
| 13 | Characteriza- tion of proteolysis during the ripening of semi-dry fermented sausages显示文摘 | Hughes M C Kerry J P Arendt E K | 2002 | Meat Science2002，62，2： | 1 |
| 14 | Extrusion of soy protein with gelatin and sugars at low moisture content显示文摘 | Guerrero P Beatty E Kerry JP | | 0，，01： | 1 |
| 15 | Extrusion of soy protein with gelatin and sugars at low moisture content显示文摘 | GUERRERO P BEATTY E KERRY J P | 2012 | J Food Eng2012，110，1： | 1 |
| 16 | Study of catalytic sites on ruthenium for hydrogenation of N- ethylcarbazole: Implications of hydrogen storage via reversible catalytic hydrogenation 显示文摘 | Morawa E K Tam K Kerry Yu K M | 2010 | Journal of Physical Chemistry (C)2010，114，21： | 1 |
| 17 | Characterization of proteolysis during the ripening of semi-dry fermented sausages显示文摘 | HUGHES M C KERRY J P ARENDT E K | 2002 | Meat Science2002，62，： | 1 |
| 18 | The course of cervical dystonia and patient satisfaction with long-term botulinum toxin A treatment 显示文摘 | Skogseid IM Kerry E | 2005 | Eur J Neurol2005，12，3： | 1 |
| 19 | High pressure processing of Australian navel orange juices:Sensory analysis and volatile flavor profiling显示文摘 | Irene A B Kerry E Sehneebeli K | 2005 | Innovative Food Science and Emerging Technologies2005，，6： | 1 |
| 20 | EFNS/ENS Guidelines for the treatment of ocular myasthenia 显示文摘 | Kerry E Elsais A Argov Z | 2014 | Eur J Neure2014，21，5： | 1 |
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