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| 1 | Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis显示文摘AIM To investigate the effects of orally gavaged aqueous rhubarb extract(RE) on 5-fluorouracil(5-FU)-induced intestinal mucositis in rats. METHODS Female Dark Agouti rats(n = 8/group) were gavaged daily(1 mL) with water, high-dose RE(HDR; 200 mg/kg) or low-dose RE(LDR; 20mg/kg) for eight days. Intestinal mucositis was induced(day 5) with 5-FU(150 mg/kg) via intraperitoneal injection. Intestinal tissue samples were collected for myeloperoxidase(MPO) activity and histological examination. Xenopus oocytes expressing aquaporin 4 water channels were prepared to examine the effect of aqueous RE on cell volume, indicating a potential mechanism responsible for modulating net fluid absorption and secretion in the gastrointestinal tract. Statistical significance was assumed at P < 0.05 by one-way ANOVA. RESULTS B o d y w e i g h t w a s s i g n i f i c a n t l y r e d u c e d i n r a t s administered 5-FU compared to healthy controls(P < 0.01). Rats administered 5-FU significantly increased intestinal MPO levels(≥ 307%; P < 0.001), compared to healthy controls. However, LDR attenuated this effect in 5-FU treated rats, significantly decreasing ileal MPO activity(by 45%; P < 0.05), as compared to 5-FU controls. 5-FU significantly reduced intestinal mucosal thickness(by ≥ 29% P < 0.001) as compared to healthy controls. LDR significantly increased ileal mucosal thickness in 5-FU treated rats(19%; P < 0.05) relative to 5-FU controls. In xenopus oocytes expressing AQP4 water channels, RE selectively blocked water influx into the cell, induced by a decrease in external osmotic pressure. As water efflux was unaltered by the presence of extracellular RE, the directional flow of water across the epithelial barrier, in the presence of extracellular RE, indicated that RE may alleviate water loss across the epithelial barrier and promote intestinal health in chemotherapy-induced intestinal mucositis.CONCLUSION In summary, low dose RE improves selected parameters of mucosal integrity and reduces ileal inflammation, manifesting from 5-FU-induced intestinal mucositis. | Juliana E Bajic Georgina L Eden Lorrinne S Lampton Ker Y Cheah Kerry A Lymn Jinxin V Pei Andrea J Yool Gordon S Howarth | 2016 | World Journal of Gastroenterology2016，22，37： | 3 |
| 2 | Structure and orientation relation of precipitates formed in Al-Cu-Mg-Ag alloys显示文摘 | Kerry S Soott V D | 1984 | Metals Science1984，18，： | 1 |
| 3 | Probes for measuring the thermal conductivity of granular materials显示文摘 | Goldsmith H J Kerrie E D Papazian V | 1981 | J Phys E: Sci Instrum1981，，14： | 1 |
| 4 | Structure of precipitate in Al-Cu-Mg-Ag alloy显示文摘 | Kerry S Scott V D | 1985 | Archiwum Nauki o Materialach1985，6，2： | 1 |
| 5 | Nucleation and growth of precipitates in Al-Cu-Mg-Ag alloys显示文摘 | Scott V D Kerry S Trumper R L | 1987 | Materials Science and Technology1987，3，10： | 1 |
| 6 | Modelling the influence of inulin as a fat substitute in comminuted meat products on their physico-chemical characteristics and eating quality using a mixture design approach 显示文摘 | Keenan D F Resconi V C Kerry J P | 2014 | Meat Science2014，96，3： | 1 |
| 7 | Volumetric modulated arc therapy for delivery of prostate radiotherapy: Comparison with intensity-modulat- ed radiotherapy and three-dimensional conformal radiotherapy显示文摘 | David P Emily V Kerry J | 2008 | Int J Radiat Oncol Biol Phys2008，72，4： | 1 |
| 8 | Nucleation and growth of precipitates in Al-Cu-Mg-Ag alloys显示文摘 | SCOTT V D KERRY S TRUMPER R L | 1987 | Mater Sci Technol1987，3，10： | 1 |
| 9 | Budgets, pricing policies and user fees in Canadian parks' tourism 显示文摘 | Kerry V S Paul F J | 1998 | Tourism Management1998，19，3： | 1 |
| 10 | The estimation of a production technology: A survey of econometric analyses of steam electric generation显示文摘 | Cowling Thomas G Kerry V Smith | 1978 | Land Economics1978，54，： | 1 |
| 11 | Structure and orientation relation of precipitates formed in Al-Cu-Mg-Ag alloys显示文摘 | KERRY S SCOTT V D | 1984 | Metal Sci1984，18，6： | 1 |
| 12 | Non - market valuation of environmental re- source : an interpretive appraisal 显示文摘 | Kerry V S | 1993 | Land Economics1993，69，1： | 1 |
| 13 | Scmliki Forest virusbased vaccines: persistence, distribution and pathological analysis in two animal systems 显示文摘 | Margaret M Morris-Dowries Kerry V | 2001 | Vaccine2001，19，： | 1 |
| 14 | Structure of precipitate in Al-Cu-Mg-Ag alloy显示文摘 | KERRY S SCOTT V D | 1985 | Archiwum Naukio Materialach1985，6，2： | 1 |
| 15 | Nucleation and growth of precipitates in Al-Cu-Mg-Ag alloys显示文摘 | Scott V D Kerry S Trumper R L | 1987 | Materials Science and Technology1987，3，10： | 1 |
| 16 | Evaluation of liquid chromatography-negative ion electrospray mass spectrometry for the determination of selected resin acids in river water 显示文摘 | Dena W M Kerry M P John V H | 2002 | J of Chromatography A2002，952，： | 1 |
| 17 | Nucleation and growth of precipitates in Al-Cu-Mg-Ag alloys 显示文摘 | SCOTT V D KERRY S TRUMPER R L | 1987 | Materials Science and Technology1987，3，10： | 1 |
| 18 | The importance of bacterial multiplication in the selection, by oxytetracycline-HC1, of oxytetracycline-resistant bacteria in marine sediment microcosms显示文摘 | Kerry J Marian S Shirley V | 1996 | Aquaculture1996，，144： | 1 |
| 19 | Innovative pharmacologic approaches to cardiopulmonary resuscitation显示文摘 | Timothy K Kerry K Shadi V | 2001 | Heart Disease2001，3，1： | 1 |
| 20 | Structure and oriegtation relationship of precipitates formed in AI-Cu-Mg-Ag alloys显示文摘 | KERRY S SCOTT V D | 1984 | Metal Science1984，18，6： | 1 |
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