|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 【特刊综述】利用雄激素受体敲除(ARKO)小鼠模型认识人类雄激素缺乏显示文摘雄激素的作用机理很复杂。最近,使用转基因修饰小鼠模型进行的雄激素受体研究使我们对雄激素作用机理有了更进一步的理解。Cre-loxP系统能够完成组织和/或细胞特异性的敲除。通过使用Cre—loxP系统已经获得了大量整体性或组织特异性雄激素受体(ARK0)敲除模型。这些ARKO模型的多个雄激素作用位点,包括心血管系统、免疫和造血系统、骨骼、肌肉、脂肪组织、前列腺和脑,均已被检测。本篇综述着重阐述了通过针对这些雄激素作用位点的ARKO小鼠模型而取得的人类雄激素缺乏的研究成果,并且指出充分理解Cre-loxPdx鼠模型的优缺点才能正确认识其表型。 | Kesha Rana Rachel A Davey Jeffrey D Zajac | 2014 | Asian Journal of Andrology2014，16，2： | 13 |
| 2 | 雄激素受体的目标基因在骨骼肌的表达显示文摘本文通过研究体外和体内模型中潜在的雄激素受体调节基因来确定骨骼肌中雄激素的合成代谢作用机制。睾酮治疗组的去势雄性小鼠与对照组去势雄性小鼠比较,其骨骼肌中肌源性调节因子肌细胞生成素的表达显著下降,而缺乏DNA结合活性的雄性雄激素受体敲除小鼠(AR^△ZF2)与野生型小鼠比较,其骨骼肌中肌源性调节因子肌细胞生成素的表达显著升高,证明了肌细胞生成素是通过雄激素/雄激素受体通路被抑制。通过12小时的骨骼肌细胞(SkMC)的成肌细胞联合双氢睾酮治疗,睾酮治疗组的去势雄性小鼠肌肉中的泛素连接酶Fbxo32被抑制,而肌肉中c—Myc表达较对照组去势雄性小鼠降低,在△R^△ZF2组小鼠肌肉中c-Myc表达升高。调节成肌细胞由增殖向分化转变的一组基因如Tceal7,p57^Kip2,Igf2和钙调磷酸酶Aa的表达在AR^△ZF2组小鼠肌肉中升高,除p57^Kip2外的上述所有基因在睾酮治疗组去势雄性小鼠肌肉中的表达均较对照组降低。因此得出结论,雄激素通过雄激素受体在雄性小鼠体内发挥作用,它在肌肉生长和发展过程中可维持成肌细胞处于增殖状态并推迟成肌细胞向分化状态转变,另外还可抑制泛素连接酶介导的导致肌肉萎缩的通路来保持小鼠肌肉质量,从而一定程度上促进肌肉不断生长达到顶峰。 | Kesha Rana Nicole KL Lee Jeffrey D Zajac Helen E MacLean | 2014 | Asian Journal of Andrology2014，16，5： | 3 |
| 3 | Mononuclearphagocytes :tissue distribution and functional heterogeneity显示文摘 | GORDON S KESHA V ST CHUNG L P | 1988 | Curr Opin Immunol1988，，1： | 1 |
| 4 | Improving Behavior of Computer Game Bots Using Fictitious Play显示文摘In modern computer games, 'bots' - intelligent realistic agents play a prominent role in the popularity of a game in the market. Typically, bots are modeled using finite-state machine and then programmed via simple conditional statements which are hard-coded in bots logic. Since these bots have become quite predictable to an experienced games player, a player might lose interest in the game. We propose the use of a game theoretic based learning rule called fictitious play for improving behavior of these computer game bots which will make them less predictable and hence, more a enjoyable game. | Ushma Kesha Patel Purvag Patel Henry Hexmoor Norman Carver | 2012 | International Journal of Automation and computing2012，9，2： | 1 |
| 5 | Cognitive Skills, Openness and Growth显示文摘 | Parantap Basu Kesha Bhattarai | 2012 | Economic Record2012，88，： | 1 |
| 6 | Macroeconomic Regulation Under the New Normal显示文摘 | Guo Kesha | 2015 | Qiu Shi2015，7，4： | 1 |
| 7 | Temporal and quantitative regulation of mitogen - activated protein kinase (MAPK) modulates cell motility and invasion显示文摘 | Krueger JS Kesha mouni VG Atanaskova N | 2001 | Oncogene2001，20，3： | 1 |
| 8 | Simulating Watershed Outlet Sediment Concentration using the Answers Model by applying Two Sediment Transport Capacity Equations 显示文摘 | Seyed Harold Ahmadi Seifoliah Arnin All Reza Kesha''arzi | 2006 | Biosystems Engineering2006，94，4： | 1 |
| 9 | Assessment of platelet largecell ratio(P~ LCR):a new platelet volume parameter in patients withischemic events显示文摘 | Kesha K Edwards L W Purohit S | 2010 | Am J Clin Path2010，134，： | 1 |
| 10 | Laparoscopic Assisted versus Open Pancreaticoduodenectomy: Early Favorable Physical Quality of Life Measures显示文摘 | Russell C. Langan Jay A. Graham Anne B. Chin Aaron J. Rubinstein Kesha Oza Jeff A. Nusbaum John Smirniotopoulos Reilly Kayser Reena Jha Nadim Haddad Firas Al-Kawas John Carroll Jane Hanna Ann Parker Waddah B. Al-Refaie Lynt B. Johnson | 2014 | Surgery2014，，： | 1 |
| 11 | 祈祷显示文摘不得不说,你几乎将我变得愚笨你说若无你相助,我不值分文你耍尽各种手段与心机却只让我百炼成钢,所向披靡你曾把我扔进地狱,让烈焰焚烧我身我不得不全力抗争。 | Sung by Kesha 李爱军 | 2018 | 英语广场2018，0，3： | 0 |
| 12 | Comprehensive Impacts of China's WTO Entry on Its Industrial Sector显示文摘China's industry currently accounts for 45 percent of the country's GDP growth. With its fast growth rate, the industrial sector shores up the steady growth of the national economy and helps boost the development of other sectors. If China's industry suffers from the country's WTO entry, the development of the whole national economy will be greatly affected. The impacts will interact and lead to magnified effects in some areas. The | Guo Kesha | 2003 | China & World Economy2003，11，2： | 0 |
| 13 | Three Relationships Must Be Balanced to Expand Domestic Demand显示文摘The slower expansion of domestic demand has put pressure on economic growth as the Chinese economy enters a new normal stage. Since the industrial structure can only be effectively upgraded through appropriately expanding aggregate demand, three relationships must be balanced: | Guo Kesha | 2019 | Beijing Review2019，62，27： | 0 |
| 14 | Actively Promoting Investment in the Construction of New Infrastructure显示文摘Infrastructure serves as the cornerstone for socioeconomic development.Accelerating the construction of new infrastructure is critical for promoting China’s economic growth and laying a solid foundation for long-term development.The 2020 Report on the Work of the Government also proposed to strengthen the construction of new infrastructure. | GUO Kesha | 2021 | China Economic Transition2021，4，1： | 0 |
| 15 | Industrial Upgrade Essential for the Manufacturing Sector’s Expansion显示文摘The development of the manufacturing industry has played a key role in China's economic growth.In 2018,the value added of manufacturing reached 26.5 trillion yuan($3.8 trillion),contributing 29.4 percent of the GDP. | Guo Kesha | 2019 | Beijing Review2019，62，31： | 0 |
| 16 | Accelerating the Construction of New Development Pattern and the Paths of Manufacturing Transformation and Upgrading显示文摘This paper reviews the basic implications and policy orientation of the new development pattern and the impacts of constructing the new development pattern on the manufacturing transformation and upgrading,based on which the choice of manufacturing transformation and upgrading paths is further discussed under the new development pattern.This paper holds that the paths of manufacturing transformation and upgrading need to be adjusted and expanded under the conditions of constructing the new development pattern.The main ideas are as follows.Restructuring the manufacturing industry chain with the large domestic market as the main guide,creating the good environment conducive to independent innovation,coordinating the regional layout for the overall high-quality manufacturing development,optimizing the business environment and enhancing the vitality and driving force of the manufacturing’s development,relying on the Belt and Road Initiative(BRI)for a higher level of international circulation.The theoretical bases for adjusting and expanding the paths of manufacturing transformation and upgrading are:embracing the new requirements with domestic circulation as the mainstay,the characteristics with the mutual reinforcement of domestic and international circulations,and promoting the manufacturing’s high-quality development and the medium and high-speed growth. | Kesha Guo Xiaoxiao Tian | 2022 | China Finance and Economic Review2022，11，1： | 0 |
| 17 | Problems and Solutions of China’s Real Estate Market Based on International Comparison显示文摘On the basis of determining the international comparison method and framework of the real estate market, this paper makes a comparative analysis on the development of China’s real estate market and those of some comparable countries (or regions). The prominent problem of the real estate market in our country is the rapid rise of urban house price and the high ratio of house price to income. The direct reason is that the social funds, especially the excessive credit funds flow into the real estate market. The indirect reason is that the land supply mode makes the land price increase too fast and account for high proportion in house price, which leads to the result that the development of real estate industry is beyond the stage of economic development. These problems are not isolated, but related to each other. The rapid rise of house prices in most of the cities, especially in the first-tier cities, is the comprehensive reflection of a large amount of credit funds promoting and the drawbacks of the land supply system in essence. The main ideas to solve the problem are correctly understanding the status, role and influence of the real estate market, stabilizing and improving the short-term control policy of the real estate market, and accelerating the establishment of a long-term mechanism for the healthy development of the real estate market. | Kesha Guo Yanyan Huang | 2018 | China Finance and Economic Review2018，7，4： | 0 |
| 18 | Driving Economic Growth with High-Quality Development of Manufacturing显示文摘Promoting the high-quality development of manufacturing is a core part of China's high-quality economic development and an important foundation for accelerating socialist modernization.According to research,high-income economies value the high-quality development of manufacturing at the middle-income stage to spur stable growth and high-quality development of the economy,making a significant contribution to smoothly entering the high-income range.Drawing lessons from their experience,at the new stage of development,China should pursue medium-and long-term strategies and industrial policies that promote high-quality development of manufacturing and thus drive high-speed growth and high-quality development of the economy,in which way China can accelerate its entry into the ranks of high-income economies as well as socialist modernization. | GUO Kesha | 2022 | Frontiers of Economics in China-Selected Publications from Chinese Universities2022，17，3： | 0 |
| 19 | 银发夫妇打扮神搭配成网红(英文)显示文摘在日本有一对白发苍苍的老夫妇,非常爱穿"情侣装",更难得的是他们将"情侣装"穿出了好品味,穿出了新高度。难怪两人注册账号才三个月,就迅速晋升为社交网红。 | Kesha Sebert | 2018 | 疯狂英语(新读写)2018，0，4： | 0 |
| 20 | Avoiding the impact of deflation and deflation expectations on economic growth显示文摘This paper predicts that the Chinese economy will unlikely encounter inflation in the short term.The major risks posed to China currently are deflation and downward pressures.Macro-regulations should have a clear orientation,combining stable growth with prevention of deflation,and integrating demand-side regulation and supply-side structural reform.The focal point of the demand-side management is to set a reasonable bar for the growth rate of the economy and the rise of price levels in order to stabilize and guide market expectations.Policy makers should adopt a moderate and directional regulatory monetary policy,setting appropriate policy objectives for the prevention of deflation,as well as make use of a variety of policy measures.China should implement a structural fiscal policy in a proactive manner,giving extra dynamic ability to the implementation of policies so that they can be more effective.Afterwards,through a deep reform of the supply-side,China can reinforce economic restructuring and boost economic growth.Policy makers should pay close attention to the reform of key areas such as state-owned enterprises,land supply,finances,taxation,and prices. | Guo Kesha | 2016 | China Finance and Economic Review2016，5，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员