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| 1 | Is there an anatomical endophenotype for neurodevelopmental disorders? A review of dual disorder anatomical likelihood estimation (ALE) meta-analyses of grey matter volumes显示文摘The term 'neurodevelopmental disorder' broadly encompasses conditions thought to arise early in development and includes schizophrenia, bipolar disorder and autism among others. These conditions share a number of genetic and environmental risk factors postulated to lead to common difficulties in socio-emotional processing, communication and cognitive function. The alternative position is that, while the same traits are affected across these conditions, the nature or direction in which they are modified may be distinct. MRI studies provide a rapidly expanding and rich database which we propose can be used to contribute to this debate. Anatomical likelihood estimation (ALE) is a method of meta-analysis applied to voxel-based MRI studies. We have adapted this method to explore the extent to which schizophrenia and bipolar disorder and schizophrenia and autism share a common brain structural phenotype. We will review this work here and discuss whether there is sufficient other evidence to justify a common framework for further research into the inter-relatedness of such conditions. | MCALONAN Grainne M YU Kevin K CHAN Raymond C K CHUA Siew E CHEUNG Charlton | 2011 | Chinese Science Bulletin2011，56，32： | 2 |
| 2 | Experimental chaos synchronization in Chua's circuit显示文摘 | Chua Leon O Ljupco Kocarev Kevin Eckert | | 0，，03： | 1 |
| 3 | Lymphopenia and interleukin-2 therapy alter homeostasis of CD4^+CD25^+ regulatory T cells显示文摘 | Hua Zhang Kevin S Chua Martin Guimond | 2005 | Nature medicine2005，11，11： | 1 |
| 4 | Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6显示文摘 | Raul Mostoslavsky Katrin F. Chua David B. Lombard Wendy W. Pang Miriam R. Fischer Lionel Gellon Pingfang Liu Gustavo Mostoslavsky Sonia Franco Michael M. Murphy Kevin D. Mills Parin Patel Joyce T. Hsu Andrew L. Hong Ethan Ford Hwei-Ling Cheng Caitlin Kenn | 2006 | Cell2006，，2： | 1 |
| 5 | ILG1:在纽约实验室大肠杆菌菌株中发现一种与噬菌体整合酶相似的新p4(英文)显示文摘目的 免疫球蛋白类别转换在生发中心 B细胞中进行 ,从而 B细胞由产生 Ig M转换到产生其他类别的免疫球蛋白如 Ig G,Ig A,Ig E.目前导致类别转换的机制还不清楚 .我们试图克隆参与类别转换的基因 .方法 原发性免疫缺陷患者 B细胞不能进行类别转换 ,而正常细胞则可以 .据此 ,我们将患者与正常人的 B细胞在同一条件下分别培养以诱导类别转换 .从培养的细胞中分别提取 RNA,并反转录成 c DNA,由此制备扩增物 (amplicon) .最后将来源于患者 B细胞的扩增物与正常人 B细胞的扩增物混合在一起 ,在一定条件下进行剔除杂交 .经 5轮剔除杂交以后 ,将剔除共同基因以后的剩余物进行克隆 .经筛选以后将阳性克隆物进行测序及序列分析 .结果 在所有克隆中 ,我们发现一个新基因 ,命名为整合酶样基因 - 1.后证实 ,该基因来源于实验室细菌株 TOP10 F'序列分析表明 ,IL G1具有原核基因特性 ,但缺乏真核细胞的基因特性 .在 DNA水平 ,IL G1与任何基因都不具有同源性 ,但在蛋白水平 ,它与来源于溶原性 p4噬菌体的整合酶具有高达 5 8%的同源性 ,我们认为 IL G1定居于一个新的溶原性 p4原噬菌体 Φ- TOP10 F.IL G1的催化活性区具有高度保守特性 ,因为活性区的关键氨基酸残基是保守的 ,这包括高度保守的 R- H- R- Y结构 . | 田文志 白慧玲 马远方 Kevin Chua Warren Strober Charles C Chu | 2002 | 第四军医大学学报2002，23，14： | 0 |
| 6 | High-finesse Fabry-Perot cavities with bidimensional Si_(3)N_(4) photonic-crystal slabs显示文摘Light scattering by a two-dimensional photonic-crystal slab(PCS)can result in marked interference effects associated with Fano resonances.Such devices offer appealing alternatives to distributed Bragg reflectors and filters for various applications,such as optical wavelength and polarization filters,reflectors,semiconductor lasers,photodetectors,bio-sensors and non-linear optical components.Suspended PCS also have natural applications in the field of optomechanics,where the mechanical modes of a suspended slab interact via radiation pressure with the optical field of a high-finesse cavity.The reflectivity and transmission properties of a defect-free suspended PCS around normal incidence can be used to couple out-of-plane mechanical modes to an optical field by integrating it in a free-space cavity.Here we demonstrate the successful implementation of a PCS reflector on a high-tensile stress Si_(3)N_(4) nanomembrane.We illustrate the physical process underlying the high reflectivity by measuring the photonic-crystal band diagram.Moreover,we introduce a clear theoretical description of the membrane scattering properties in the presence of optical losses.By embedding the PCS inside a high-finesse cavity,we fully characterize its optical properties.The spectrally,angular-and polarization-resolved measurements demonstrate the wide tunability of the membrane’s reflectivity,from nearly 0 to 99.9470±0.0025%,and show that material absorption is not the main source of optical loss.Moreover,the cavity storage time demonstrated in this work exceeds the mechanical period of low-order mechanical drum modes.This so-called resolved-sideband condition is a prerequisite to achieve quantum control of the mechanical resonator with light. | Xu Chen Clément Chardin Kevin Makles Charles Caër Sheon Chua Rémy Braive Isabelle Robert-Philip Tristan Briant Pierre-François Cohadon Antoine Heidmann Thibaut Jacqmin Samuel Deléglise | 2016 | Light(Science & Applications)2016，5，1： | 0 |
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