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| 1 | Animal models of ex vivo lung perfusion as a platform for transplantation research显示文摘Ex vivo lung perfusion(EVLP) is a powerful experimental model for isolated lung research. EVLP allows for the lungs to be manipulated and characterized in an external environment so that the effect of specific ventilation/perfusion variables can be studied independent of other confounding physiologic contributions. At the same time,EVLP allows for normal organ level function and real-time monitoring of pulmonary physiology and mechanics. As a result,this technique provides uniqueadvantages over in vivo and in vitro models. Small and large animal models of EVLP have been developed and each of these models has their strengths and weaknesses. In this manuscript,we provide insight into the relative strengths of each model and describe how the development of advanced EVLP protocols is leading to a novel experimental platform that can be used to answer critical questions in pulmonary physiology and transplant medicine. | Kevin Nelson Christopher Bobba Samir Ghadiali Don Hayes Jr Sylvester M Black Bryan A Whitson | 2014 | World Journal of Experimental Medicine2014，4，2： | 2 |
| 2 | Management and outcomes of congenital chylothorax in the neonatal intensive care unit:A case series显示文摘Importance:Congenital chylothorax is a rare condition with pulmonary and multiorgan system effects,for which there are no standardized treatment recommendations.Collective review of known cases offers some conclusions and suggestions for treatment.Objective:The aim of this study was to present a case series of 5 patients who were treated in the neonatal intensive care unit with chylothorax.Methods:We describe 5 infants who were diagnosed prenatally with hydrops fetalis and postnatally had clinically significant congenital chylothorax.Results:Treatment guidelines specific to congenital forms of chylothorax have not yet been developed,although there are consistent trends across our cases.Four of the 5 infants in this study have survived to date.Chylothorax was treated with chest tube placement and chylous fluid drainage,scrupulous attention to fluid balance,mechanical ventilation,and nutritional management and,in 3 cases,with octreotide infusions.Some of the infants also required treatment for immunodeficiency and altered coagulation pathways.None of the infants underwent surgical thoracic duct ligation.Interpretation:Aided by the advantage of prenatal diagnosis,many cases of congenital chylothorax can be successfully treated by a combination of nutritional and medical management as well as careful attention to fluid and electrolyte balance and avoidance of infection,thereby avoiding the need for surgical ligation of the thoracic duct. | Helen Healy Kevin Gipson Susanne Hay Sara Bates Thomas Bernard Kinane | 2017 | Pediatric Investigation2017，1，1： | 2 |
| 3 | Clopidogrel Effect on Platelet REactivity in Patients With Stent Thrombosis显示文摘 | Paul A. Gurbel Kevin P. Bliden Waiel Samara Jason A. Yoho Kevin Hayes Mulugeta Z. Fissha Udaya S. Tantry | 2005 | Journal of the American College of Cardiology2005，，10： | 2 |
| 4 | The ATHEROMA (Atorvastatin Therapy: Effects on Reduction of Macrophage Activity) Study显示文摘 | Tjun Y. Tang Simon P.S. Howarth Sam R. Miller Martin J. Graves Andrew J. Patterson Jean-Marie U-King-Im Zhi Y. Li Stewart R. Walsh Andrew P. Brown Peter J. Kirkpatrick Elizabeth A. Warburton Paul D. Hayes Kevin Varty Jonathan R. Boyle Michael E. Gaunt And | 2009 | Journal of the American College of Cardiology2009，，22： | 1 |
| 5 | Transcription factor cycling on the insulin promoter显示文摘 | John Barrow Colin W. Hay Laura A. Ferguson Hilary M. Docherty Kevin Docherty | 2005 | FEBS Letters2005，，2： | 1 |
| 6 | Hypoxemia without persistent right-to-left pressure gradient across a patent foramen ovale:A clinical challenge显示文摘Patent foramen ovale (PFO) closure for systemic hypoxemia is controversial. The first systematic, albeit retrospective, study was recently presented which showed good procedural and clinical success for PFO closure for this indication. We present a case of acute right to left intra-cardiac shunt across PFO where the shunting is not persistent. Hence making a decision on PFO closure based on the aforementioned promising trial may not have been the right decision for the patient. This case highlights that the decision on PFO closure for such indication needs to be individualized. We also review the sparse literature on PFO closure for this indication and discuss how the decision making for such indication needs to be individualized. | Sadip Pant Kevin Hayes Abhishek Deshmukh David L Rutlen | 2013 | World Journal of Cardiology2013，5，7： | 1 |
| 7 | Toxicity Reduction Evaluation, Toxicity Identification Evaluation and Toxicity Tracking in Direct Toxicity Assessment显示文摘 | Matt Hutchings Ian Johnson Elaine Hayes Andrew E. Girling John Thain Kevin Thomas Rachel Benstead Graham Whale Joy Wordon Ruth Maddox Phillip Chown | 2004 | Ecotoxicology2004，，5： | 1 |
| 8 | Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers显示文摘 | Meredith Yeager Nianqing Xiao Richard B. Hayes Pascal Bouffard Brian Desany Laura Burdett Nick Orr Casey Matthews Liqun Qi Andrew Crenshaw Zdenek Markovic Karin M. Fredrikson Kevin B. Jacobs Laufey Amundadottir Thomas P. Jarvie David J. Hunter Robert Hoov | 2009 | Human Genetics2009，，2： | 1 |
| 9 | Preventing tomorrow’s sudden cardiac death today显示文摘 | Sana M. Al-Khatib Gillian D. Sanders Mark Carlson Aida Cicic Anne Curtis Gregg C. Fonarow Peter W. Groeneveld David Hayes Paul Heidenreich Daniel Mark Eric Peterson Eric N. Prystowsky Philip Sager Marcel E. Salive Kevin Thomas Clyde W. Yancy Wojciech Zare | 2008 | American Heart Journal2008，，4： | 1 |
| 10 | Needle-free Biojector injection of a dengue virus type 1 DNA vaccine with human immunostimulatory sequences and the GM-CSF gene increases immunogenicity and protection from virus challenge in Aotus monkeys显示文摘 | Kanakatte Raviprakash Dan Ewing Monika Simmons Kevin R Porter Trevor R Jones Curtis G Hayes Richard Stout Gerald S Murphy | 2003 | Virology2003，，： | 1 |
| 11 | Reduced hippocampal and amygdala activity predicts memory distortions for trauma reminders in combat-related PTSD显示文摘 | Jasmeet Pannu Hayes Kevin S. LaBar Gregory McCarthy Elizabeth Selgrade Jessica Nasser Florin Dolcos Rajendra A. Morey | 2010 | Journal of Psychiatric Research2010，，5： | 1 |
| 12 | Direct Rho-associated kinase inhibiton induces cofilin dephosphorylation and neurite outgrowth in PC-12 cells显示文摘 | Zhiqun Zhang Andrew K. Ottens Stephen F. Larner Firas H. Kobeissy Melissa L. Williams Ronald L. Hayes Kevin K. W. Wang | 2006 | Cellular & Molecular Biology Letters2006，，1： | 1 |
| 13 | Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver显示文摘 | Neil R. Kitteringham Azman Abdullah Joanne Walsh Laura Randle Rosalind E. Jenkins Rowena Sison Christopher E.P. Goldring Helen Powell Christopher Sanderson Samantha Williams Larry Higgins Masayuki Yamamoto John Hayes B. Kevin Park | 2010 | Journal of Proteomics2010，，8： | 1 |
| 14 | Concept of defibrillation vector in the management of high defibrillation threshold显示文摘We present a case where defibrillation threshold was dangerously elevated to the point that the patient had no safety margin,and his implantable cardioverter-defibrillator generator was discovered to have migrated.Generator migration reduces the distance between the can and the coil,effectively creating a smaller bipolar current and sparing the left ventricle from the current needed for defibrillation.This case underscores the importance of securing the generator in place,as this patient would have been spared multiple shocks and an invasive medical procedure had his generator been better secured. | Kevin Hayes Abhishek Deshmukh Sadip Pant Gareth Tobler Hakan Paydak | 2013 | World Journal of Cardiology2013，5，4： | 0 |
| 15 | Randomized intervention and outpatient follow-up lowers 30-d readmissions for patients with hepatic encephalopathy,decompensated cirrhosis显示文摘BACKGROUND We previously reported national 30-d readmission rates of 27% in patients with decompensated cirrhosis(DC).AIM To study prospective interventions to reduce early readmissions in DC at our tertiary center.METHODS Adults with DC admitted July 2019 to December 2020 were enrolled and randomized into the intervention(INT) or standard of care(SOC) arms. Weekly phone calls for a month were completed. In the INT arm, case managers ensured outpatient follow-up, paracentesis, and medication compliance. Thirty-day readmission rates and reasons were compared.RESULTS Calculated sample size was not achieved due to coronavirus disease 2019;240 patients were randomized into INT and SOC arms. 30-d readmission rate was 33.75%, 35.83% in the INT vs 31.67% in the SOC arm(P = 0.59). The top reason for 30-d readmission was hepatic encephalopathy(HE, 32.10%). There was a lower rate of 30-d readmissions for HE in the INT(21%) vs SOC arm(45%, P = 0.03). There were fewer 30-d readmissions in patients who attended early outpatient follow-up(n = 17, 23.61% vs n = 55, 76.39%, P = 0.04).CONCLUSION Our 30-d readmission rate was higher than the national rate but reduced by interventions in patients with DC with HE and early outpatient follow-up. Development of interventions to reduce early readmission in patients with DC is needed. | Antoinette Pusateri Kevin Litzenberg Claire Griffiths Caitlin Hayes Bipul Gnyawali Michelle Manious Sean G Kelly Lanla F Conteh Sajid Jalil Haikady N Nagaraja Khalid Mumtaz | 2023 | World Journal of Hepatology2023，15，6： | 0 |
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