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| 1 | Characterization of six tumorsuppressor genes and microsatellite instability in hepatocellular carcinomain southern African blacks显示文摘AIM To analyse cumulative loss of heterozygosity (LOH) of chromosomal regions and tumor suppressor genes in hepatocellular carcinomas (HCCs) from 20 southern African blacks. METHODS p53, RB1, BRCA1, BRCA2, WT1 and E cadherin genes were analysed for LOH, and p53 gene was also analysed for the codon 249 mutation, in tumor and adjacent non tumorous liver tissues using molecular techniques and 10 polymorphic microsatellite markers. RESULTS p53 codon 249 mutation was found in 25% of the subjects, as was expected, because many patients were from Mozambique, a country with high aflatoxin B 1 exposure. LOH was found at the RB1, BRCA2 and WT1 loci in 20%(4/*!20) of the HCCs, supporting a possible role of these genes in HCC. No LOH was evident in any of the remaining genes. Reports of mutations of p53 and RB1 genes in combination, described in other populations, were not confirmed in this study. Change in microsatellite repeat number was noted at 9/*!10 microsatellite loci in different HCCs, and changes at two or more loci were detected in 15%(3/*!20) of subjects. CONCLUSION We propose that microsatellite/genomic instability may play a role in the pathogenesis of a subset of HCCs in black Africans. | Martins C Kedda MA Kew MC | 1999 | World Journal of Gastroenterology1999，5，6： | 21 |
| 2 | Hepatic iron overload and hepatocellular carcinoma显示文摘 | Kew MC | 2009 | Cancer Lett2009，286，1： | 1 |
| 3 | Hepatitis B virus DNA in serum of healthy black African adults positive for hepatitis B surface antibody alone: possible association with recombination between genotype A and D显示文摘 | Owiredu WK Kramvis A Kew MC | 2001 | J Med Virol2001，64，： | 1 |
| 4 | HLA expression in human hep- atocellular carcinoma 显示文摘 | Paterson AC Sciot R Kew MC | 1988 | Br J Cancer1988，57，4： | 1 |
| 5 | Molecular analysis of hepatitis B virus genomes isolated from black African patients with fulminant hepatitis B显示文摘 | Kramvis A Kew MC | 2001 | J Med Virol2001，65，3： | 1 |
| 6 | Nucleic acid sequence analysis of the precore region of hepatitis B virus from sera of southern African black adult carriers of the virus显示文摘 | A Kramvis S Bukofzer MC Kew E Song | 1997 | Hepatology1997，，1： | 1 |
| 7 | Primary squamous cell carcinoma of the liver occurring in association with hepatolithiasis显示文摘 | Song E Kew MC | 1984 | Cancer1984，53，： | 1 |
| 8 | Distinctive sequence characteristics of subgenotype A isolates of hepatitis B virus from South Africa显示文摘 | Kimbri GC Kramvis A Kew MC | 2004 | J GEN Virol2004，85，5： | 1 |
| 9 | HLA expression in human hepatoeellular eareinoma显示文摘 | Paterson AC Sciot R Kew MC et aI | 1988 | Br J Cancer1988，57，4： | 1 |
| 10 | Epidemiology chronic hepatitis B virus infec- tion,hepatocellular carcinoma and hepatitis B virus-in- duced hepatocellular carcinoma显示文摘 | Kew MC | 2010 | Pathol Biol (Paris)2010，58，4： | 1 |
| 11 | Primary squamous cell carcinoma of the liver occurring in association with hepatolithlasis 显示文摘 | Song E Kew MC Grieve T | 1984 | Cancer1984，53，： | 1 |
| 12 | Detection of hepatitis B virus DNA directily in human serum by a simplified molecular hybridization test:comprision to HBeAg/anti-HBe status in HBeAg carriers显示文摘 | Lieberman HM Labrecque DR Kew MC | 1983 | Hepatology1983，3，： | 1 |
| 13 | Hepatic iron of Jerload and hepatocellular carcinoma 显示文摘 | KEW MC | 2014 | Liver Cancer2014，3，1： | 1 |
| 14 | Hepatitis B virus DNA in serum of healthy black African adults positive for hepatitis B surface antibody alone:possible association with recombination between genotypes A and D显示文摘 | Owiredu WK Kramvis A Kew MC | | 0，，： | 1 |
| 15 | Serum aminotransferase concentration as evidence of hepatocellular damage 显示文摘 | Kew MC | 2000 | Lancet2000，355，9204： | 1 |
| 16 | Nonspecific messenger RNA of a-fetoprotein in peripheral blood in detecting early spread of hepatocellular carcinoma in black Africans显示文摘 | Kedda MA Kew MC Skelton M | 1998 | Gastroenterol Hepatol1998，13，6： | 1 |
| 17 | Comparison of hepatitis B virus DNA extractions from serum by the QIAamp blood kit,GeneReleaser,and the phenol-chloroform method显示文摘 | Kramvis A Bukofzer S Kew MC | 1996 | J Clin Microbiol1996，34，11： | 1 |
| 18 | Hepatitis virus and hepatocellular carcinoma显示文摘 | | 1998 | Res Virol1998，149，： | 1 |
| 19 | Rupture of hepatocellular carcinoma as a result of blunt abdominal trauma显示文摘 | Kew MC Hodkinson J | 1991 | Am J Gastroenterol1991，86，8： | 1 |
| 20 | Epidemiology of chronic hepatitis B virus infection, hepatocellular carcinoma, and hepatitis B virus-induced hepato- cellular carcinoma 显示文摘 | Kew MC | 2010 | Pathol Biol (Paris)2010，58，4： | 1 |
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