| 1 | A carbazole-hemicyanine dye based ratiometric fluorescent probe for selective detection of bisulfite(HSO_3^-)in cells and C. elegans显示文摘Bisulfite(HSO_3) is an important sulfur dioxide(SO_2) derivative, which plays a major role in many physiological processes and is also closely associated with a variety of diseases. Thus the development of highly selective and sensitive fluorescent probes is essential to detect HSO_3 in living cells. In this work,we report the synthesis and analysis of a ratiometric fluorescent probe for selective detection of HSO_3 based on the 1,4-nucleophilic addition reaction with the carbazole as an electron donor(D) and aldehyde group as an electron acceptor(A). The addition of HSO_3 and other ions to our probe can be observed by UV vis and fluorescence spectrometry. Our investigation proved that the probe is highly selective and sensitive for HSO_3 and ratiometric changes. Moreover, the probe has good cell permeability and was successfully applied to the detection of exogenous HSO_3 in Hela cells and C. elegans. | Keying Bi Rui Tan Ruiting Hao Lanxi Miao Yanqi He Xianghua Wu Junfeng Zhang Rui Xu | 2019 | Chinese Chemical Letters2019，30，3： | 1 |
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