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| 1 | 与隐形眼镜相关的感染性角膜炎-埃及5年流行病学研究(英文)显示文摘目的:研究埃及Tanta大学医院与隐形眼镜相关的感染性角膜炎患者的不同流行病学特点,评估这类疾病各方面的特点,以提高患者对这类疾病的认识,找出可行的解决方案。方法:选取我院2009-01/2013-12期间在眼科门诊就诊的所有角膜炎患者仔细检查,并对所有与隐形眼镜相关的感染性角膜炎患者进一步检查和调查。结果:本研究期间,总共108 496位有不同主诉的患者中,1463例(1.3%)患有不同形式的角膜炎,其中151例(0.1%)为隐形眼镜相关感染性角膜炎。结果发现患有隐形眼镜相关感染性角膜炎常见的年龄群<30岁,大多数是学生(64%),家庭人数多且较为拥挤,农村居民高于城市居民,患者采用户外水源及污水处理不卫生。从病史分析发现:隐形眼镜相关感染性角膜炎通常为彻夜使用,储存或者配戴不卫生,或者隐形眼镜来源不安全,例如化妆品商店和理发店。结膜囊微生物培养结果提示阳性率92%,阴性率8%。大多数培养阳性的病例是由细菌和真菌混合感染引起,共53例(38.1%),单纯细菌感染43例(30.9%),真菌31例(22.3%),阿米巴12例(8.6%)。结论:与隐形眼镜相关的感染性角膜炎常见于学生群体,与农村生活、户外供水、不卫生的污水处理等危险因素有关。彻夜配戴、储存或配戴不卫生及隐形眼镜来源不安全都可增加隐形眼镜相关感染性角膜炎的发病率。 | Mohammad Mostafa Khater Mohammad Sameh El-Shorbagy | 2015 | 国际眼科杂志2015，15，10： | 5 |
| 2 | Bone marrow mesenchymal stem cell transplantation downregulates plasma level and the microglia expression of transforming growth factor β1 in the acute phase of cerebral cortex ischemia显示文摘Background:Both bone marrow mesenchymal stem cell(BM-MSC)and transforming growth factor-β1(TGF-β1)have a strong anti-inflammatory capacity in stroke.But their relationship has not been well addressed.In this study,we investigated how intravenous BM-MSC transplantation in rats effected the expression of TGF-β148 h post cerebral ischemia,and we analyzed the main cells that produce TGF-β1.Methods:We used a distal middle cerebral artery occlusion(dMCAO)model in twenty Sprague-Dawley(SD)rats.The rats were randomly divided into two groups:the ischemic control group and the postischemic BM-MSC transplantation group.One hour after the dMCAO model was established,the rats were injected in the tail vein with either 1 ml saline or 1×106 BM-MSCs suspended in 1 ml saline.ELISAs were used to detect TGF-β1 content in the brain infarct core area,striatum and the plasma at 48 h after cerebral infarction.Immunofluorescent staining of brain tissue sections for TGF-β1,Iba-1,CD68 and NeuN was performed to determine the number and the proportion of double stained cells and to detect possible TGF-β1 producing cells in the brain tissue.Results:Forty-eight hours after ischemia,the TGF-β1 content in the infarcted area of the BM-MSC transplantation group(23.94±4.48 pg/ml)was significantly lower than it was in the ischemic control group(34.18±4.32 pg/ml)(F=13.534,P=0.006).The TGF-β1 content in the rat plasma in the BM-MSC transplantation group(75.91±12.53 pg/ml)was significantly lower than it was in the ischemic control group(131.18±16.07 pg/ml)(F=36.779,P=0.0002),suggesting that after transplantation of BM-MSCs,TGF-β1 levels in the plasma decreased,but there was no significant change in the striatum area.Immunofluorescence staining showed that the total number of nucleated cells(1037.67±222.16 cells/mm2)in the infarcted area after transplantation was significantly higher than that in the ischemic control group(391.67±69.50 cells/mm2)(F=92.421,P<0.01);the number of TGF-β1+cells after transplantation(35.00±13.66 cells/mm2)was significantly reduced in comparison to that in the ischemic control group(72.33±32.08 cells/mm2)(F=37.680,P<0.01).The number of TGF-β1+/Iba-1+microglia cells in the transplantation group(3.67±3.17 cells/mm2)was significantly reduced in comparison to that of the ischemic control group(13.67±5.52 cells/mm2)(F=29.641,P<0.01).The proportion of TGF-β1+/Iba-1+microglia cells out of all Iba-1+microglia cells after transplantation(4.38±3.18%)was significantly decreased compared with that in the ischemic control group(12.81±4.86%)(F=28.125,P<0.01).Conclusions:Iba-1+microglia is one of the main cell types that express TGF-β1.Intravenous transplantation of BM-MSCs does not cooperate with TGF-β1+cells in immune-regulation,but reduces the TGF-β1 content in the infarcted area and in the plasma at 48 h after cerebral infarction. | Zhao-Hui Liang Jian-Juan Gu Wen-Xiu Yu Yun-Qian Guan Mostafa Khater Xiao-Bo Li | 2020 | Chronic Diseases and Translational Medicine2020，6，4： | 4 |
| 3 | Laparoscopic versus open appendectomy显示文摘 | M. Marzouk M. Khater M. Elsadek A. Abdelmoghny | 2003 | Surgical Endoscopy2003，，5： | 2 |
| 4 | Association of high-sensitivity C-reactive protein with carotid artery intima-media thickness in hypertensive older adults显示文摘 | Moatassem S. Amer Amal E. Elawam Mohamed S. Khater Omar H. Omar Randa A. Mabrouk Hend M. Taha | 2011 | Journal of the American Society of Hypertension2011，，5： | 2 |
| 5 | Preservation of Juniperus thurifera L.:a rare endangered species in Algeria through in vitro regeneration显示文摘Juniperus thurifera L.is an endemic Cupres saceae from the Aure`s Mountains of north eastern Algeria and endangered,in part,due to the scarcity of viable seeds It is threatened by other abiotic factors and the lack of an effective management strategy will increase its risk o extinction.The dearth of information on its in vitro regeneration impedes its application in forest managemen programs.We therefore developed a micropropagation protocol using microcuttings with auxiliary buds.Cuttings were grown on different combinations of media supplemented with plant growth regulators at different concentrations.The highest number of shoots and branches regenerated from original shoots was obtained on Woody Plant Medium(WPM)supplemented with 6-benzylaminopurine(BAP)(0.5 mg L^(-1))and 2,4-dichlorophe noxyacetic acid(2,4-D)(0.25 mg L^(-1)).The best elongation of shoots was achieved with WPM supplemented with0.5 mg L^(-1)of BAP and 0.25 or 1 mg L^(-1) of 2,4-D.On the second subculture,shoots had a higher number of branches than those of the first.The highest rooting rate,38.8%,was obtained with shoots cultured in 1/2 Murashige and Skoog(MS)medium supplemented with 5.0 mg L^(-1)each of indol-3-butyric(IBA)and naphthalene acetic acid(NAA).Similarly,the highest root numbers and lengths were produced on 1/2 MS medium supplemented with IBA and NAA(5.0 mg L^(-1)each).During transfer to acclimatization,rates of plant losses of 50% occurred.The second part of the experiment showed that the best shoot callusing was on WPM supplemented with BAP and 2,4-D,with either the combination 0.5+0.25 or 0.25+0.25 mg L^(-1).The results of this research provide a starting point for further studies on in vitro regeneration of J.thurifera for the sustainable management of its unique ecosystem in the Mediterranean basin. | Nadia Khater Halima Benbouza | 2019 | Journal of Forestry Research2019，30，1： | 2 |
| 6 | In silico methods for linking genes and secondary metabolites: The way forward显示文摘In silico methods for linking genomic space to chemical space have played a crucial role in genomics driven discovery of new natural products as well as biosynthesis of altered natural products by engineering of biosynthetic pathways.Here we give an overview of available computational tools and then briefly describe a novel computational framework,namely retro-biosynthetic enumeration of biosynthetic reactions,which can add to the repertoire of computational tools available for connecting natural products to their biosynthetic gene clusters.Most of the currently available bioinformatics tools for analysis of secondary metabolite biosynthetic gene clusters utilize the“Genes to Metabolites”approach.In contrast to the“Genes to Metabolites”approach,the“Metabolites to Genes”or retro-biosynthetic approach would involve enumerating the various biochemical transformations or enzymatic reactions which would generate the given chemical moiety starting from a set of precursor molecules and identifying enzymatic domains which can potentially catalyze the enumerated biochemical transformations.In this article,we first give a brief overview of the presently available in silico tools and approaches for analysis of secondary metabolite biosynthetic pathways.We also discuss our preliminary work on development of algorithms for retro-biosynthetic enumeration of biochemical transformations to formulate a novel computational method for identifying genes associated with biosynthesis of a given polyketide or nonribosomal peptide. | Shradha Khater Swadha Anand Debasisa Mohanty | 2016 | Synthetic and Systems Biotechnology2016，1，2： | 2 |
| 7 | Phase Ⅱ trial of 96-hour paclitaxel plus oral estramustine phosphate in metastatic hormone-refractory prostate cancer显示文摘 | Hudes G R Nathan F Khater C | 1997 | J Clin Oncol1997，15，： | 1 |
| 8 | Influence of Cr203, LiF, CaFz and TiO2 nucleants on the crystallization behavior and microstructure of glass-ceramics based on blast-furnace slag显示文摘 | KHATER G A | 2011 | Ceram lnt2011，37，7： | 1 |
| 9 | Control of diarrhea by fiber-enriched diet in ICU patients on enteral nutri- tion: a prospective randomized controlled trial显示文摘 | Rushdi TA Pichard C Khater YH | 2004 | Clin Nutr2004，23，6： | 1 |
| 10 | A simplified gamma-ray self-attenuation correction in bulk samples显示文摘 | Khater A E M Ebaid Y Y | 2008 | Appl radiat isot2008，66，3： | 1 |
| 11 | Asso-ciation of high-sensitivity C-reactive protein with carotid artery intima-media thickness in hypertensive older adults 显示文摘 | Amer Moatassem S Elawam Areal E Khater Mohamed S | 2011 | JASH2011，5，5： | 1 |
| 12 | The role of Cr2O3, LiF and their mixtures on crystalline phase formation and mi?crostructure in Ba, Ca, Mg aluminosilicates glass 显示文摘 | OMARA A ELSHENNAURI A W A KHATER G A | 1991 | Bri Ceram Trans J1991，90，6： | 1 |
| 13 | Association of high-sen- sitivity C-reactive protein with carotid artery intima-media thickness in hypertensive older adults 显示文摘 | Amer MS Elawam AE Khater MS | 2011 | Am Society Hypertension2011，5，： | 1 |
| 14 | Clinical and experimental study of autologous fat grafting after processing by centrifugation and serum lavage显示文摘 | Khater R Atanassova P Anastassov Y | | 0，，01： | 1 |
| 15 | Evaluation of relationships among refractive and topographic parameters 显示文摘 | BUDAK K KHATER T T FRIEDMAN N J | 1999 | J Cataract Refract Surg1999，25，6： | 1 |
| 16 | Glass-ceramics in the CaO-MgOA12O3 SiO2 system based on industrial waste materials显示文摘 | Khater G A | 2010 | J Non-Cryst Solids2010，356，5254： | 1 |
| 17 | The use of saudi slag production of glass-ceramic materials 显示文摘 | Khater G A | 2002 | Ceramics International2002，18，1： | 1 |
| 18 | Severe acute respiratory syndrome:an overview显示文摘 | Khater FJ Moonnan JP | 2003 | South Med J2003，96，9： | 1 |
| 19 | Evaluation of insulin like growth factor-1 (IGF-1) level and its impact on muscle and bone mineral density in frail elderly male显示文摘 | Mohamad MI Khater MS | 2015 | Arch Gerontol Geriatr2015，60，1： | 1 |
| 20 | Control of diarrhea by fi-ber-enriched diet in ICU patients on enteral nutrition : a pro-spective randomized controlled trial显示文摘 | Rushdi TA Pichard C Khater YH | 2004 | Clin Nutr2004，23，： | 1 |
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