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| 1 | Mechanisms involved in Korean mistletoe lectin-induced apoptosis of cancer cells显示文摘AIM: To investigate the anti-cancer mechanisms of Korean mistletoe lectin (Viscum album coloratum agglutinin,VCA) using a human colon cancer cell line (COLO). METHODS: Cytotoxic effects of VCA on COLO cells were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay in vitro and tumor-killing effects in vivo. To study the mechanisms involved,the expression of various pro-caspases,anti-apoptotic proteins,and death receptors was determined by western blot. To determine which death receptor is involved in VCA-induced apoptosis of COLO cells,cytotoxicity was examined by MTT assay after treatment with agonists or antagonists of death receptors. RESULTS: VCA killed COLO cells in a time-and dose-dependent manner and induced complete regression of tumors in nude mice transplanted with COLO cells. Treatment of COLO cells with VCA activated caspase-2,-3,-8,and -9 and decreased expression of anti-apoptotic molecules including receptor interacting protein,nuclear factor-κB,X-linked inhibitor of apoptosis protein,and Akt/protein kinase B. We then examined the involvement of death receptors in VCA-induced apoptosis. Only tumor necrosis factor receptor 1,among the death receptors examined,was involved in apoptosis of COLO cells,evidenced by inhibition of VCA-induced apoptosis and decreased activation of caspases,particularly caspase-8,by tumor necrosis factor receptor 1 antagonizing antibody.CONCLUSION: VCA-induced apoptotic COLO cell death is due to the activation of caspases and inhibition of anti-apoptotic proteins,in part through the tumor necrosis factor receptor 1 signaling pathway. | Lee-Yong Khil Wi Kim Suyun Lyu Won Bong Park Ji-Won Yoon Hee-Sook Jun | 2007 | World Journal of Gastroenterology2007，13，20： | 4 |
| 2 | Evaluation of properties of concrete using fluosilicate salts and metal (Ni,W) compounds显示文摘To improve watertightness and antibiosis of sewage structure concrete, the antimicrobial watertight admixture was made with fluosilicate salts and antimicrobial compounds. And fresh properties, watertightness, harmlessness and antibiosis of concrete were investigated experimentally. As a result, the fresh properties of concrete were similar to those of an ordinary concrete, without setting time delay. Compressive strength and carbonation resistance of concrete were better than those of an ordinary concrete. Finally it was confirmed that the antimicrobial watertight admixture of concrete had an antibiosis inhibiting SOB growth. | Gyu-Yong KIM Eui-Bae LEE Bae-Su KHIL Seung-Hun LEE | 2009 | 中国有色金属学会会刊:英文版2009，19，B09： | 2 |
| 3 | Gelatin-coatedmagnetic iron oxide nanoparticles as carrier system: Drug loadingand in vitro drug release study显示文摘 | GAIHREA B KHIL S M LEEC D R | 2009 | International Journal of Phar-maceutics t2009，365，12： | 1 |
| 4 | Allele fre- quencies for 15 autosomal STR markers in the Libyan population 显示文摘 | Khodiet el Khil H Fadhlaoui Zid K Gusmao L | 2012 | Ann Hum Biol2012，39，1： | 1 |
| 5 | Characterization of nano-structured poly (ε-caprolactone) nonwoven mats via electrospinning显示文摘 | LEE K KIM H KHIL M | | 0，，04： | 1 |
| 6 | Electrospun nanofibrous polyurethane membrane as wound dressing 显示文摘 | KHIL M CHA D KIM H | 2003 | Journal of Biomedical Materials Research: Part B: Applied Biomaterials2003，67，2： | 1 |
| 7 | Electrospun nanofibrous poly-urethane membrane as wound dressing 显示文摘 | Khil MS Cha DI Kim HY | 2003 | J Biomed Mater ResB2003，67，2： | 1 |
| 8 | TiO 2 nanofibers doped with rare earth elements and their photocatalytic activity显示文摘 | M. Shamshi Hassan Touseef Amna O-Bong Yang Hyun-Chel Kim Myung-Seob Khil | 2012 | Ceramics International2012，，： | 1 |
| 9 | Natxofibrous mats of poly(trimethylene terephthalate) via electrospinning显示文摘 | KHIL M S KIM H Y KIM M S | 2004 | Polymer2004，45，： | 1 |
| 10 | Multiple Open- circuit Faults Diagnosis in Back-to-back Converters of PMSG Drives for Wind Turbine Systems显示文摘 | JLASS1 I ESTIMA J O KHIL E | 2015 | IEEE Transac- tions on Power Electronics2015，30，5： | 1 |
| 11 | Y chromosome microsatellite variation in three populations of Jerba Island (Tunisia) 显示文摘 | Marrakchi RT Loueslati BY | 2000 | Ann Hum Genet2000，65，： | 1 |
| 12 | Effect of geometric parame- ters on the liquid film thickness and air core formation in a swirl injector显示文摘 | Kim S Khil T Kim D | 2009 | Measurement Science and Technology2009，20，1： | 1 |
| 13 | The Effect of Strong Electrolytes on Aqueous Solutions of Sodium Salts of Native and Sulfonated显示文摘 | S L Khil'ko E V Titov A A Fedoseeva | 2001 | Humic Acids Colloid Journal2001，5，63： | 1 |
| 14 | Phase I study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer显示文摘 | Freytag SO Khil M Stricker H | 2002 | Cancer Res2002，62，17： | 1 |
| 15 | Radiosensitization by 5-fluorocytosine of human colorectal carcinoma cells in culture transduced with cytosine deaminase gene显示文摘 | Khil M S Kim J H Mullen C A | 1996 | Clin Cancer Res1996，2，1： | 1 |
| 16 | Electrospun Nanofibrous Polyurethane Membrane as Wound Dressing 显示文摘 | KHIL M S CHAD I KIM H Y | 2003 | Journal of Biomedical Material Research Part B2003，67，2： | 1 |
| 17 | Effects of orifice internal flow on break- up characteristics of like-doublet injectors 显示文摘 | Jung K Khil T Yoon Y | 2006 | Journal of Propul- sion and Power2006，22，3： | 1 |
| 18 | Novel fabricated matrix viaelectrospirming for tissue engineering显示文摘 | Khil M S Bhattarai S R Kim HY | 2005 | Journal of BiomedicalMaterials Research2005，72，： | 1 |
| 19 | Characterization of nanostructured po1y (ε-caprolactone) nonwoven mats via electrospinning显示文摘 | Lee KH Kim HY Khil MS | 2003 | Polymer2003，44，： | 1 |
| 20 | Novel fabricatedmatrix via electrospinning for tissue engineer- ing显示文摘 | KHIL M S BHATTARAI S R KIM H Y | 2005 | J Biomed Mater Res B2005，72，13： | 1 |
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