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| 1 | Characterization of hepatic progenitors from human fetal liver using CD34 as a hepatic progenitor marker显示文摘AIM: To enrich putative hepatic progenitors from the developing human fetal liver using CD34 as a marker. METHODS: Aborted fetuses of 13-20 wk were used for the isolation of liver cells. The cells were labeled with anti CD34; a marker used for isolating progenitor population and the cells were sorted using magnetic cell sorting. The positive fractions of cells were assessed for specific hepatic markers. Further, these cells were cultured in vitro for long term investigation. RESULTS: Flow cytometric and immunocytochemical analysis for alphafetoprotein (AFP) showed that the majority of the enriched CD34 positive cells were positive for AFP. Furthermore, these enriched cells proliferated in the long term and maintained hepatic characteristics in in vitro culture. CONCLUSION: The study shows that aborted human fetal liver is a potential source for isolation of hepatic progenitors for clinical applications. The study also demonstrates that CD34 can be a good marker for the enrichment of progenitor populations. | Parveen Nyamath Ayesha Alvi Aejaz Habeeb Sanjeev Khosla Aleem A Khan CM Habibullah | 2007 | World Journal of Gastroenterology2007，13，16： | 9 |
| 2 | The strigolactone receptor D14 targets SMAX1 for degradation in response to GR24 treatment and osmotic stress显示文摘The effects of the phytohormone strigolactone(SL)and smoke-derived karrikins(KARs)on plants are generally distinct,despite the fact that they are perceived through very similar mechanisms.The homologous receptors DWARF14(D14)and KARRIKIN-INSENSITIVE2(KAI2),together with the F-box protein MORE AXILLARY GROWTH2(MAX2),mediate SL and KAR responses,respectively,by targeting different SMAX1-LIKE(SMXL)family proteins for degradation.These mechanisms are putatively well-insulated,with D14-MAX2 targeting SMXL6,SMXL7,and SMXL8 and KAI2-MAX2 targeting SMAX1 and SMXL2 in Arabidopsis thaliana.Recent evidence challenges this model.We investigated whether D14 can target SMAX1 and whether this occurs naturally.Genetic analysis indicates that the SL analog GR24 promotes D14-SMAX1 crosstalk.Although D14 shows weaker interactions with SMAX1 than with SMXL2 or SMXL7,D14 mediates GR24-induced degradation of SMAX1 in plants.Osmotic stress triggers SMAX1 degradation,which is protective,through SL biosynthesis and signaling genes.Thus,D14-SMAX1 crosstalk may be beneficial and not simply a vestige of the evolution of the SL pathway. | Qingtian Li Elena Sánchez Martín-Fontecha Aashima Khosla Alexandra R.F.White Sunhyun Chang Pilar Cubas David C.Nelson | 2022 | Plant Communications2022，3，2： | 5 |
| 3 | QRS detection using K -Nearest Neighbor algorithm (KNN) and evaluation on standard ECG databases显示文摘 | Indu Saini Dilbag Singh Arun Khosla | 2013 | Journal of Advanced Research2013，，4： | 2 |
| 4 | Identification of strategy parameters for particle swarm optimizer through Taguchi method显示文摘Particle swarm optimization (PSO), like other evolutionary algorithms is a population-based stochastic algorithm inspired from the metaphor of social interaction in birds, insects, wasps, etc. It has been used for finding promising solutions in complex search space through the interaction of particles in a swarm. It is a well recognized fact that the performance of evolu- tionary algorithms to a great extent depends on the choice of appropriate strategy/operating parameters like population size, crossover rate, mutation rate, crossover operator, etc. Generally, these parameters are selected through hit and trial process, which is very unsystematic and requires rigorous experimentation. This paper proposes a systematic based on Taguchi method reasoning scheme for rapidly identifying the strategy parameters for the PSO algorithm. The Taguchi method is a robust design approach using fractional factorial design to study a large number of parameters with small number of experiments. Computer simulations have been performed on two benchmark functions—Rosenbrock function and Griewank function—to validate the approach. | KHOSLA Arun KUMAR Shakti AGGARWAL K.K. | 2006 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2006，7，12： | 2 |
| 5 | Models for optimal lead time reduction 显示文摘 | Hill A V Khosla I S | 1992 | Production and Operations Management1992，1，2： | 1 |
| 6 | The Vitreoscilla hameoglobingene:molecularcloning,nucleotide sequence and genetic expression in Escherichia coli显示文摘 | BARLEY J E | 1988 | Molecular Genetics1988，214，： | 1 |
| 7 | Osteoporosis:now and the future 显示文摘 | Rachner TD Khosla S Hofbauer LC | 2011 | Lancet2011，377，9773： | 1 |
| 8 | Hyperuricemia induces endothelial dysfunction显示文摘 | Khosla UM Zharikov S Finch JL | 2005 | Kidney Int2005，67，5： | 1 |
| 9 | Hyperuricemia induces en- dothelial dysfunction 显示文摘 | Khosla UM Zharikov S Finch JL | 2005 | Kidney Int2005，67，5： | 1 |
| 10 | Role of RANK ligand in mediating increased bone resorption in early postmenopausal women显示文摘 | Eghbali-Fatourechi G Khosla S Sanyal A Boyle WJ Lacey DL Riggs BL | | 0，，： | 1 |
| 11 | The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption显示文摘 | Hofbauer L.C Khosla S Dunstan C.R | | 0，，： | 1 |
| 12 | Economic feasibility of variable-rate nitrogen application utilizing site-specific management zones 显示文摘 | Koch B Khosla R Frasier W M | 2004 | Agronomy Journal2004，96，6： | 1 |
| 13 | Osteoporosis: now and thefuture显示文摘 | Rachner TD Khosla S Hot'bauer LC | 2011 | Lancet2011，377，9773： | 1 |
| 14 | Osteoporosis:now and the future显示文摘 | Rachner TD Khosla S Hofbauer LC | 2011 | Lancet2011，377，9773： | 1 |
| 15 | Novel aspects of quantitation of immunogenic wheat gluten peptides by liquid chromatography- mass spectrometry/mass spectrometry 显示文摘 | Sealey- Voyksner J A Khosla C Voyksner R D | 2010 | Journal of Chromatography A2010，1217，25： | 1 |
| 16 | Update on estrogens and the skeleton显示文摘 | Khosla S | 2010 | J ClinEndocrinol Metab2010，95，8： | 1 |
| 17 | Hyperuricemia induces endothelial dysfunction显示文摘 | Khosla UM Zharikov S Finch JL | 2005 | Kidney Int2005，67，5： | 1 |
| 18 | Minireview: The OPG/RANKL/RANK system 显示文摘 | Khosla S | 2001 | Endocrinology2001，142，12： | 1 |
| 19 | Heat-related illnesses显示文摘 | Khosla R Cuntupalli KK | 1999 | Crit Care Clin1999，15，2： | 1 |
| 20 | The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption显示文摘 | Hofbauer L C Khosla S Dunstan C R | 2000 | J Bone Miner Res2000，，15： | 1 |
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