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| 1 | 血浆亲环蛋白A水平对冠状动脉疾病患者预后的影响显示文摘氧化应激状态下,血管平滑肌细胞、炎症细胞分泌亲环蛋白A(cyclophilin A,CyPA),并激活血小板功能。最近研究表明,血浆CyPA水平是诊断冠状动脉疾病的新型生物标志物。血浆CyPA水平对这些患者的预后是否有影响仍未阐明。方法:连续纳入接受诊断性冠状动脉造影的患者511例,测定血浆CyPA水平、高敏C反应蛋白(high-sensitivity C-reactive protein,hsCRP)和血浆脑钠尿肽水平, | Ohtsuki T Satoh K Omura J Kikuchi N Satoh T Kurosawa R Nogi M Sunamura S Yaoita N Aoki T Tatebe S Sugimura K Takahashi J Miyata S Shimokawa H 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 9 |
| 2 | Percutaneous radiofrequency ablation for early hepatocellular carcinoma: Risk factors for survival显示文摘AIM: To evaluate outcomes of radiofrequency ablation(RFA) therapy for early hepatocellular carcinoma(HCC) and identify survival- and recurrence-related factors. METHODS: Consecutive patients diagnosed with early HCC by computed tomography(CT) or magnetic resonance imaging(MRI)(single nodule of ≤ 5 cm, or multi-(up to 3) nodules of ≤ 3 cm each) and who underwent RFA treatment with curative intent between January 2010 and August 2011 at the Instituto do Cancer do Estado de S o Paulo, Brazil were enrolled in the study. RFA of the liver tumors(with 1.0 cm ablative margin) was carried out under CT-fluoro scan and ultrasonic image guidance of the percutaneous ablation probes. Procedure-related complications were recorded. At 1-mo post-RFA and 3-mo intervals thereafter, CT and MRI were performed to assess outcomes of complete response(absence of enhancing tissue at the tumor site) or incomplete response(enhancing tissue remaining at the tumor site). Overall survival and diseasefree survival rates were estimated by the Kaplan-Meier method and compared by the log rank test or simple Cox regression. The effect of risk factors on survival was assessed by the Cox proportional hazard model. RESULTS: A total of 38 RFA sessions were performed during the study period on 34 patients(age in years: mean, 63 and range, 49-84). The mean follow-up time was 22 mo(range, 1-33). The study population showed predominance of male sex(76%), less severe liver disease(Child-Pugh A, n = 26; Child-Pugh B, n = 8), and single tumor(65%). The maximum tumor diameters ranged from 10 to 50 mm(median, 26 mm). The initial(immediately post-procedure) rate of RFAinduced complete tumor necrosis was 90%. The probability of achieving complete response was significantly greater in patients with a single nodule(vs patients with multi-nodules, P = 0.04). Two patients experienced major complications, including acute pulmonary edema(resolved with intervention) and intestinal perforation(led to death). The 1- and 2-year overall survival rates were 82% and 71%, respectively. Sex, tumor size, initial response, and recurrence status influenced survival, but did not reach the threshold of statistical significance. Child-Pugh class and the model for end-stage liver disease score were identified as predictors of survival by simple Cox regression, but only Child-Pugh class showed a statistically significant association to survival in multiple Cox regression analysis(HR = 15; 95%CI: 3-76 mo; P = 0.001). The 1-and 2-year cumulative disease-free survival rates were 65% and 36%, respectively. CONCLUSION: RFA is an effective therapy for local tumor control of early HCC, and patients with preserved liver function are the best candidates. | Luciana Kikuchi Marcos Menezes Aline L Chagas Claudia M Tani Regiane SSM Alencar Marcio A Diniz Venncio AF Alves Luiz Augusto Carneiro D’Albuquerque Flair José Carrilho | 2014 | World Journal of Gastroenterology2014，20，6： | 5 |
| 3 | Generating optimal topologies in structural design using a homogenization method显示文摘 | Bendsoe M P Kikuchi | 1988 | Computer methods in Applied mechanics and Engineering1988，71，： | 2 |
| 4 | P, inversion in three homologous series of ferroelectric 5-(2-fluoro-alkyloxyl)-2-(4-n-alkylphenyl)-pyrimidines显示文摘 | Saito S Murashiro K Kikuchi M | 1993 | Ferroelectrics1993，147，： | 2 |
| 5 | 312-nanometer ultraviolet Blitht (Narrow-band UVB)induces apoptosis of T ceils within psoriatic lesions 显示文摘 | Ozawa M Ferenczi K Kikuchi T | 1999 | J Exp Med1999，189，： | 1 |
| 6 | Caspases cleave the amino-terminal calpain inhibitory unit of calpastatin during apoptosis in human Jurkat T cells 显示文摘 | Nonaka T Maki M Kikuchi H Imajoh-Ohmi S | 2000 | J Biochem2000，127，2： | 1 |
| 7 | Hepatocellular carcinoma after transcatheter hepatic arterial embolization:a histopathologic study of 84 resected cases显示文摘 | Kikuchi M Okazaki M | 1994 | Cancer1994，73，9： | 1 |
| 8 | Generating optimal topologies in structural design using a homogenization method显示文摘 | Bendsoe M P Kikuchi N | 1988 | Comp Meth Apple Mech Engrg1988，71，19： | 1 |
| 9 | Expression of monocytc chemoattractant protein-1 in primary cultures of rabbit intervertebral disc cells 显示文摘 | Yoshida M Nakamura T Kikuchi T | 2002 | Orthop Res2002，20，： | 1 |
| 10 | The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis显示文摘 | Sun X Minohara M Kikuchi H | 2006 | J Neuroimmunol2006，180，12： | 1 |
| 11 | Generating optimal topologies in structural design using homogenization method显示文摘 | BENDSΦE M P KIKUCHI N | 1988 | Computer Methods in Applied Mechanics and Engineering1988，71，2： | 1 |
| 12 | The thickness effects of the CCT specimen显示文摘 | Machida K Kikuchi M Miyamoto H | 1986 | Bulletin of JSME1986，29，： | 1 |
| 13 | New diagnostic imaging of gastointestinal tumors:a preliminary study of three-dimensional tumor structure and volumetry 显示文摘 | Kikuchi S Kida M Kobayashi K | 2005 | Anticancer Res2005，25，4： | 1 |
| 14 | The RNA heli?case RIG-I has an essential function in double-stranded RNA-in?duced innate antiviral responses显示文摘 | Yoneyama M Kikuchi M Natsukawa T | 2004 | Nat Immunol2004，5，7： | 1 |
| 15 | Ilicifoliosides a and b, bis-secoiridoid glycosides from Osmanthus ilicifolius 显示文摘 | Shigeaki S Machida K Kikuchi M | 2007 | Heterocycles2007，74，： | 1 |
| 16 | In-Depth Distribution of Rusts on a Plain Carbon Steel and Weathering Steels Exposed to Coastal-Industri- al Atmosphere for 17 year显示文摘 | Asami K Kikuchi M | 2003 | Corrosion Science2003，45，11： | 1 |
| 17 | Generating optimal topologies in structural design using a homogenization method 显示文摘 | BENDSOE M P KIKUCHI N | 1988 | Computer Methods in Applied Mechanics and Engineering1988，71，2： | 1 |
| 18 | Preparation and Mechanical Properties of Calcium Phosphate/Copoly-L-Lactide Composites 显示文摘 | Kikuchi M Suetsugu Y Tanaka J | 1997 | Journal of Materials Science Materials in Medicine1997，8，6： | 1 |
| 19 | Efficacy of soft electron(low-energy electron beam) for soybean decontamination in comparison with gammarays显示文摘 | Kikuchi O k Todoriki S Saito M Hayashi T | 2003 | Journal of Food Science2003，68，2： | 1 |
| 20 | Effect of ZnO loading to activated carbon on Pb(11)adsorption from aqueous solution显示文摘 | Kikuchi Y Qian Q R Machida M | 2006 | Carbon2006，44，： | 1 |
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