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| 1 | Clinical significance of CT-defined minimal ascites in patients with gastric cancer显示文摘AIM: To study the clinical significance of minimal ascites,which was only defined by the CT and whose nature was not determined preoperatively, in the relationship with the peritoneal carcinomatosis.METHODS: The medical records and the dynamic CT films of 118 patients with gastric cancer were reviewed.Factors associated with peritoneal carcinomatosis were analyzed in 40 patients who had CT-defined ascites of which the nature was surgically confirmed.RESULTS: Only 12.5-25% of the CT-defined minimal ascites, whose volume was estimated to be less than 50 mL, were associated with peritoneal carcinomatosis.When the estimated CT-defined ascitic volume was 50 mL or more, peritoneal carcinomatosis was identified in 75-100%. When CT-defined lymph node enlargements were not found beyond the regional gastric area,perigastricinvasions were not suspected, and the size of tumor was less than 3 cm, peritoneal carcinomatosis seemed significantly less accompanied at the univariate analysis. However, except for the minimal volume of CTdefined ascites in comparison with the mild or more,other factors were not confirmed multivariately.CONCLUSION: In the patients with gastric cancer, CTdefined minimal ascites alone is rarely associated with peritoneal carcinomatosis, if it does not accompany other signs suggestive of malignant seeding. Therefore,consideration of active curative resection should not be hesitated, if CT-defined minimal ascites is the only delusive sign. | Dong Kyung Chang Ji Won Kim Byung Kwan Kim Kook Lae Lee Chi Sung Song Joon Koo Han In Sung Song | 2005 | World Journal of Gastroenterology2005，11，42： | 14 |
| 2 | Keystone design perforator island flap in facial defect reconstruction显示文摘Facial defect coverage is a common subject in the field of reconstructive surgery.There are many methods for facial defect reconstruction,and reconstructive surgeons should choose the most appropriate method on a case-by-case basis to achieve both functional and aesthetic improvement.Among various options for facial reconstruction,the local flap technique is considered the best reconstructive modality to provide good tissue matches of color and texture,which is consistent with the ideal goal of reconstruction(replacement of like-with-like).Keystone design perforator island flap(KDPIF),devised by Behan in 2003,has been applied to various fields of reconstructive surgery in the past decade due to its design simplicity,robust vascular supply,and reproducibility.Several studies have reported KDPIF reconstruction of facial defects,such as large parotid defects,small-to-moderate nasal defects,and eyelid defects.However,KDPIF has been used relatively less in facial defects than in other body regions,such as the trunk and extremities.The purpose of this review is to provide an organized overview of facial KDPIF reconstruction including the classification of KDPIF,modifications,physiology,mechanism of flap movement,consideration of facial relaxed skin tension lines and aesthetics,surgical techniques,clinical applications,and precautions for successful execution of KDPIF reconstruction. | Soo Yeon Lim Chi Sun Yoon Hyun Gun Lee Kyu Nam Kim | 2020 | World Journal of Clinical Cases2020，8，10： | 5 |
| 3 | Thioredoxin Reductase Type C (NTRC) Orchestrates Enhanced Thermotolerance to Arabidopsis by Its Redox-Dependent Holdase Chaperone Function显示文摘Genevestigator 分析为 NADPH-thioredoxin reductase 显示了抄本感应的热吃惊,在光的类型 C (NTRC ) 。这里,我们在 Arabidopsis 显示出 NTRC 的 overexpression | Ho Byoung Chae Jeong Chan Moon Mi Rim Shin Yong Hun Chi Young Jun Jung Sun Yong Lee Ganesh M. Nawkar Hyun Suk Jung Jae Kyung Hyun Woe Yeon Kim Chang Ho Kang Dae-Jin Yun Kyun Oh Lee Sang Yeol Lee | 2013 | Molecular Plant2013，6，2： | 5 |
| 4 | Hydrodynamic optimization of a triswach显示文摘A new methodology for hydrodynamic optimization of a Tri SWACH is developed, which considers not only the positions of the side hulls but also the shape of the side hulls. In order to account for the strong near-field interference effects between closely-spaced multihulls, an integrated hydrodynamic computational tool that consists of a potential-flow based simple CFD tool and an Euler/RANS/Navier-Stokes based advanced CFD tool has been further developed and integrated into a practical multiobjective hydrodynamic optimization tool. The other components of this hydrodynamic optimization tool consist of a hull shape representation and modification module and an optimization module. This enhanced multi-objective hydrodynamic optimization tool has been applied to the hydrodynamic design optimization of the Tri SWACH for reduced drag by optimizing the side hulls only. A new methodology is developed to optimize side hull forms so that the Tri SWACH has a minimal drag for a wide speed range and for various side hull positions. Two sets of the side hulls are developed and used for the design of two optimal Tri SWACH models. Model tests are carried out for two optimal Tri SWACH models at Webb Institute for validations. Substantial drag reductions have been obtained for a wide range of speed. | YANG Chi HUANG Fuxin KIM Hyunyul | 2014 | Journal of Hydrodynamics2014，26，6： | 4 |
| 5 | Monosialoganglioside 1 may alleviate neurotoxicity induced by propofol combined with remifentanil in neural stem cells显示文摘Monosialoganglioside 1(GM1) is the main ganglioside subtype and has neuroprotective properties in the central nervous system. In this study, we aimed to determine whether GM1 alleviates neurotoxicity induced by moderate and high concentrations of propofol combined with remifentanil in the immature central nervous system. Hippocampal neural stem cells were isolated from newborn Sprague-Dawley rats and treated with remifentanil(5, 10, 20 ng/m L) and propofol(1.0, 2.5, 5.0 μg/m L), and/or GM1(12.5, 25, 50 μg/m L). GM1 reversed combined propofol and remifentanil-induced decreases in the percentage of 5-bromodeoxyuridine(+) cells and also reversed the increase in apoptotic cell percentage during neural stem cell proliferation and differentiation. However, GM1 with combined propofol and remifentanil did not affect β-tubulin(+) or glial fibrillary acidic protein(+) cell percentage during neural stem cell differentiation. In conclusion, we show that GM1 alleviates the damaging effects of propofol combined with remifentanil at moderate and high exposure concentrations in neural stem cells in vitro, and exerts protective effects on the immature central nervous system. | Jiang Lu Xue-qin Yao Xin Luo Yu Wang Sookja Kim Chung He-xin Tang Chi Wai Cheung Xian-yu Wang Chen Meng Qing Li | 2017 | Neural Regeneration Research2017，12，6： | 4 |
| 6 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 7 | Control of T H 17/T reg Balance by Hypoxia-Inducible Factor 1显示文摘 | Eric V. Dang Joseph Barbi Huang-Yu Yang Dilini Jinasena Hong Yu Ying Zheng Zachary Bordman Juan Fu Young Kim Hung-Rong Yen Weibo Luo Karen Zeller Larissa Shimoda Suzanne L. Topalian Gregg L. Semenza Chi V. Dang Drew M. Pardoll Fan Pan | 2011 | Cell2011，，5： | 3 |
| 8 | Investigation of cell mechanics using single-beam acoustic tweezers as a versatile tool for the diagnosis and treatment of highly invasive breast cancer cell lines: an in vitro study显示文摘Advancements in diagnostic systems for metastatic cancer over the last few decades have played a significant role in providing patients with effective treatment by evaluating the characteristics of cancer cells.Despite the progress made in cancer prognosis,we still rely on the visual analysis of tissues or cells from histopathologists,where the subjectivity of traditional manual interpretation persists.This paper presents the development of a dual diagnosis and treatment tool using an in vitro acoustic tweezers platform with a 50MHz ultrasonic transducer for label-free trapping and bursting of human breast cancer cells.For cancer cell detection and classification,the mechanical properties of a single cancer cell were quantified by single-beam acoustic tweezers(SBAT),a noncontact assessment tool using a focused acoustic beam.Cell-mimicking phantoms and agarose hydrogel spheres(AHSs)served to standardize the biomechanical characteristics of the cells.Based on the analytical comparison of deformability levels between the cells and the AHSs,the mechanical properties of the cells could be indirectly measured by interpolating the Young’s moduli of the AHSs.As a result,the calculated Young’s moduli,i.e.,1.527kPa for MDA-MB-231(highly invasive breast cancer cells),2.650kPa for MCF-7(weakly invasive breast cancer cells),and 2.772 kPa for SKBR-3(weakly invasive breast cancer cells),indicate that highly invasive cancer cells exhibited a lower Young’s moduli than weakly invasive cells,which indicates a higher deformability of highly invasive cancer cells,leading to a higher metastasis rate.Single-cell treatment may also be carried out by bursting a highly invasive cell with high-intensity,focused ultrasound. | Hae Gyun Lim Hsiao-Chuan Liu Chi Woo Yoon Hayong Jung Min Gon Kim Changhan Yoon Hyung Ham Kim KKirk Shung | 2020 | Microsystems & Nanoengineering2020，6，1： | 3 |
| 9 | Biocompatible custom ceria nanoparticles against reactive oxygen species resolve acute inflammatory reaction after intracerebral hemorrhage显示文摘Intracerebral 出血(ICH ) 是有高死亡率,当前为没有有效治疗的击的一种破坏子类型。强烈煽动性的反应引起的 perihematomal 浮肿自己比 hematoma 更有害并且能导致神经病学的恶化和死亡。Ceria nanoparticles (CeNPs ) 是有势力有为生物医学的应用的潜力的免费激进的 scavengers。当氧化应力在 post-ICH 发炎起一个主要作用,我们假设了那 CeNPs 可能免于 ICH。测试这个假设,核心 CeNPs 用一个修改反向的 micelle 方法被综合并且用 phospholipid 聚乙烯乙二醇(木钉) 盖住完成 biocompatibility。我们调查了是否我们的定做的 biocompatible CeNPs 对 ICH 有保护的效果。CeNPs 在 vitro 减少了氧化应力,导致 hemin 的 cytotoxicity,和发炎。在一个啮齿类动物 ICH 模型,静脉内地管理了 CeNPs,建议他们能通过损坏血大脑障碍扩散是主要在出血性的半球散布了。而且, CeNPs 在出血性的损害和煽动性的蛋白质表示附近稀释了 microglia/macrophage 招募。最后, CeNP 处理作为与控制相比在 68.4% 减少了大脑浮肿。这些结果与 ICH 为病人作为一个新奇治疗学的代理人揭示 CeNPs 的大潜力。 | Dong-Wan Kang Chi Kyung Kim Han-Gil Jeong Min Soh Taeho Kim In-Young Choi SeuI-Ki Ki Do Yeon Kim Wookjin Yang Taeghwan Hyeon Seung-Hoon Lee | 2017 | Nano Research2017，10，8： | 3 |
| 10 | The immunohistochemical overexpression of ribonucleotide reductase regulatory subunit M1 (RRM1) protein is a predictor of shorter survival to gemcitabine-based chemotherapy in advanced non-small cell lung cancer (NSCLC)显示文摘 | Jae Jin Lee Chi Hoon Maeng Seon Kyung Baek Gou Young Kim Jee-Hong Yoo Cheon Woong Choi Yee Hyung Kim Young-Tae Kwak Dae-Hyun Kim Young Kyung Lee Jung Bo Kim Si-Young Kim | 2010 | Lung Cancer2010，，2： | 3 |
| 11 | Synthesis and characterization of core/shell structured nanophosphors CePO_4:Tb@LaPO_4 by solvothermal method显示文摘Core/shell structured CePO4:Tb(III) @LaPO4 and CePO4:Tb(III) were successfully synthesized in tris(2-ethylhexyl) phosphate(TEHP) and diethylene glycol(DEG) solvents for comparison of the two techniques in open air and closed reaction vessel.Morphology and crystal structure of the core/shell nanophosphors were determined by using X-ray diffraction(XRD) and transmission electron microscopy(TEM) ,which showed that nanophosphors had diameter of about 5-10 nm with the monoclinic monazite phase.The nanophosphors obtained by close vessel procedure showed smaller size,more homogeneity and pure crystallite.The luminescent measurements were done upon the different excitation wavelengths in ultraviolet region and at room temperature to elucidate the influences of the used solvents and the reaction temperatures.It was found that CePO4:Tb@LaPO4 prepared by the close vessel synthesis showed the intensity of green band of the transfer from 5D4 to 7F5 energy level,which was strongly increased,and the luminescent decay time was 3.2 ms,which was longer than that of naked CePO4:Tb phosphor. | Dinh Xuan Loc Tran Thi Kim Chi Tran Thu Huong Nguyen Vu Tran Kim Anh Wieslaw Strek Le Quoc Minh | 2011 | Journal of Rare Earths2011，29，12： | 2 |
| 12 | Spatial distribution of particulate matter (PM 10 and PM 2.5 ) in Seoul Metropolitan Subway stations显示文摘 | Ki Youn Kim Yoon Shin Kim Young Man Roh Cheol Min Lee Chi Nyon Kim | 2007 | Journal of Hazardous Materials2007，，1： | 2 |
| 13 | Protective effect of aqueous extract of Perilla frutescens on tert -butyl hydroperoxide-induced oxidative hepatotoxicity in rats显示文摘 | Min-Kyung Kim Huyn-Sun Lee Eun-Jin Kim Nam-Hee Won Young-Min Chi Byoung-Chul Kim Kwang-Won Lee | 2007 | Food and Chemical Toxicology2007，，9： | 2 |
| 14 | Reproductive outcomes of patients undergoing radical trachelectomy for early-stage cervical cancer显示文摘 | C.H. Kim N.R. Abu-Rustum D.S. Chi G.J. Gardner M.M. Leitao J. Carter R.R. Barakat Y. Sonoda | 2012 | Gynecologic Oncology2012，，3： | 2 |
| 15 | Robotic tumor-specific mesorectal excison of rectal cancer: short-term outcome of a pilot randomized trial显示文摘 | S. H. Baik Y. T. Ko C. M. Kang W. J. Lee N. K. Kim S. K. Sohn H. S. Chi C. H. Cho | 2008 | Surgical Endoscopy2008，，7： | 2 |
| 16 | Factors Determining Early Left Atrial Reverse Remodeling After Mitral Valve Surgery显示文摘 | Deok-Kyu Cho Jong-Won Ha Byung-Chul Chang Se-Hwa Lee Se-Jung Yoon Chi Young Shim Jung Rae Cho Jung-Sun Kim Eui-Young Choi Se-Joong Rim Namsik Chung | 2008 | The American Journal of Cardiology2008，，3： | 2 |
| 17 | Antibacterial Behaviour of Quaternized Poly(vinyl chloride)-g-Poly(4-vinyl pyridine) Graft Copolymers显示文摘Amphiphilic graft copolymers consisting of poly(vinyl chloride)(PVC) main chains and poly(4-vinyl pyridine)(P4VP) side chains were synthesized via atom transfer radical polymerization(ATRP) using direct initiation of chlorine atoms. The successful synthesis of PVC-g-P4 VP graft copolymers was confirmed by Fourier transform infrared spectroscopy(FTIR) and proton nuclear magnetic resonance(1H-NMR). Transmission electron microscope(TEM) and small angle X-ray scattering(SAXS) analysis showed that PVC-g-P4 VP exhibited microphase-separated, ordered structure with 37.6 nm of domain spacing, which was not observed in neat PVC. For antibacterial applications, the tertiary nitrogen atoms of PVC-gP4 VP was quaternized using 1-bromohexane, as confirmed by FTIR measurements. Bacteria including Escherichia coli(E. coli), Staphylococcus aureus(S. aureus), Bacillus cereus(B. cereus), and Pseudomonas aeruginosa(P. aeruginosa) were completely killed in 24 h on the quaternized PVC-g-P4VP(46% grafting) surface, indicating its excellent antibacterial behavior while it showed to be cytotoxic to mammalian cell. | Madhumita Patel Rajkumar Patel Won Seok Chi Jong Hak Kim Jung-Suk Sung | 2015 | Chinese Journal of Polymer Science2015，33，2： | 2 |
| 18 | Moudgil,Regulation of autoimmune arthritis by the pro-inflammatory cytokine interferon-γ 显示文摘 | Kim E Y Chi H H Bouziane M | 2008 | Clin Immunol2008，127，： | 1 |
| 19 | Formulation of an extended release tablet containing dexibuprofen显示文摘 | Yi HG Chi MH Kim Y | 2008 | Arch Pharm Res2008，31，12： | 1 |
| 20 | A study of the viral etiology of histiocytic necrotizing lymphadenitis(Kikuchi-Fujimoto disease)显示文摘 | Huh J Chi Hs Kim SS | 1998 | J Korean Med Sci1998，13，： | 1 |
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