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| 1 | The DNA-binding factor Ctcf critically controls gene expression in macrophages显示文摘巨噬细胞在免疫和动态平衡起一个重要作用。在经由特定的受体的病原体识别之上,他们很快导致煽动性的回答。这个过程紧在 transcriptional 水平被控制。DNA 有约束力的锌手指蛋白质 CCCTC 有约束力的因素(Ctcf ) 是远程的染色质相互作用的一个关键管理者并且协调在抄写因素和基因表达式进程之间的特定的通讯。在这研究, Ctcf 基因被使用转基因的 Cre-LoxP 系统明确地在 myeloid 房间删除。在 myeloid 房间的 Ctcf 基因的有条件的删除在 vivo 导致了温和显型。显著地展出的 Ctcf 缺乏的老鼠减少了主要 histocompatibility 的表示在肝的建筑群(MHC ) 班 II。Ctcf 缺乏的巨噬细胞表明了正常表面显型和吞噬作用能力。在像使用费的受体(TLR ) 之上刺激,他们生产了支持 inflammatory cytokines IL-12 和 IL-6 的正常层次,但是表明了一个强烈损害的能力生产肿瘤坏死因素(TNF ) 和 IL-10,以及表示 IL-10 家庭成员 IL-19, IL-20 和 IL-24。一起拿,我们的数据表明涉及巨噬细胞功能调整的 Ctcf 的一个角色。 | Tatjana Nikolic Dowty Movita Margaretha EH Lambers Claudia Ribeiro de Almeida] Paula Biesta Kim Kreefft Marjolein JW de Bruijn Ingrid Bergen Niels Galjart Andre Boonstra Rudi Hendriks | 2014 | Cellular & Molecular Immunology2014，11，1： | 2 |
| 2 | Reactive oxygen species mediate Aβ(25-35)-induced activation of BV2 microglia显示文摘 | Kang J Park EJ Jou I Kim JH Joe EH | 2001 | Neuroreport2001，12，7： | 2 |
| 3 | Expression of MAGE-1 ,-2 ,and -3 genes in gastric carcinomas and cancer cell lines derived from Korean patients 显示文摘 | Kim YM Lee YH Shin SH Kim EH Choi YW Lee KM | 2001 | J Korean Med Sci2001，16，1： | 1 |
| 4 | Overexpression of matrix metalloproteinase-2 mediates phenotypic transformation of lens epithelial cells显示文摘 | Seomun Y Kim J Lee EH | 2001 | Biochem J2001，358，1： | 1 |
| 5 | Metallothionein-iii provides neuronal protection through activation of nuclear factor-κB via the TrkA/phosphatidylinositol-3 kinase/Akt signaling pathway显示文摘 | Kim HG Hwang YP Han EH | 2009 | Toxicol Sci2009，112，2： | 1 |
| 6 | Recommendation for use of the newly introduced pneumococcal protein conjugate vaccines in Korea 显示文摘 | Choi EH Kim KH Kim YJ Kim JH Park SE Lee I-LI Eun BW Jo DS Choi KM Hong YJ | 2011 | Korean J Pediatr2011，54，4： | 1 |
| 7 | Overexpression of matrix metallo-proteinase-2 mediates phenotypic transformation of lens epithelialcells显示文摘 | Seomun Y Kim J Lee EH | 2001 | Biochem J2001，358，1： | 1 |
| 8 | Synergistic vasculogeniceffects of AMD3100 and stromal-cell-derived factor-1 a in vasanervorum of the sciatic nerve of mice with diabetic peripheralneuropathy显示文摘 | Kim BJ Lee JK Schuchman EH | 2013 | Cell Tissue Res2013，15，8： | 1 |
| 9 | Renoprotective effects of sildenafil in POCA-salt hypertensive rats 显示文摘 | Bae EH Kim IJ Joo SY | 2012 | Kidney Blood Press Res2012，36，1： | 1 |
| 10 | Wnt/beta-catenin signalling: from plasma membrane to nucleus显示文摘 | Kim W Kim M Jho EH | 2013 | Biochem J2013，450，1： | 1 |
| 11 | Long-Term outcomes of hemi- spheric disconnection in pediatric patients with intractable epi- lepsy 显示文摘 | Lee YJ Kim EH Yum MS | 2014 | J Clin Neurol2014，10，2： | 1 |
| 12 | Surgical and endocrino- logical outcomes in the treatment of growth hormone-secre- ting pituitary adenomas according to the shift of surgical paradigm 显示文摘 | Ku CR Kim EH Oh MC | 2012 | Neurosurgery2012，71，： | 1 |
| 13 | Efficacy and Tolerability of Split-Dose PEG Compared withSplit-Dose Aqueous Sodium Phosphate for Outpatient Colonoscopy: A RandomizedControlled Trial显示文摘 | EH Seo TO Kim TG Kim | 2011 | Dig Dis Sci2011，56，29： | 1 |
| 14 | Oxidized low density lipoprotein suppresses lipopolysaccharide-induced inflammatory responses in microglia: oxidative stress acts through control of inflammation 显示文摘 | Kim OS Lee CS Joe EH | 2006 | Biochem Biophys Res Commun2006，342，： | 1 |
| 15 | I hmlocysleinc as a risk factor for development of microalbuminuria in type 2 diabetcs显示文摘 | Cho EH Kim EH Kim WG | 2010 | Korean Diabetes J2010，34，3： | 1 |
| 16 | Effects of a death education program on life satisfaction and attitude toward death in college students显示文摘 | Kim EH Lee E | 2009 | Journal of Korean Acade- my of Nursing2009，39，1： | 1 |
| 17 | TMPRSS4 induces invasion and epithelial-mesenchymal transition through upregulation of integrin α5 and its signaling pathways显示文摘 | Kim S Kang HY Nam EH | 2010 | Carcinogenesis2010，31，： | 1 |
| 18 | Changes in pain behavior and glial activation in the spinal dorsal horn after pulsed radiofrequency current administration to the dorsal root ganglion in a rat model of lumbar disc herniation: laboratory investigation显示文摘 | Cho HK Cho YW Kim EH | 2013 | J Neurosurg Spine2013，19，2： | 1 |
| 19 | CEO Ownership, External Governance, and Risk -taking显示文摘 | Kim EH Lu Y | 2011 | Journal of Financial Economics2011，102，2： | 1 |
| 20 | Developmental change of amplitude-integrated electroencephalographic activity in preterm infants with intraventricular hemorrhage显示文摘 | Sohn JA Kim HS Lee EH | | 0，，12： | 1 |
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