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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Diagnostic Performance of Virtual Ganstrioscopy Using MDCT in Early Gastric Cancer Compareed with 2D Axial CT: Focusing on Interobserver Variation显示文摘 | Kim JH Eun HW Choi JH | 2007 | AJR2007，189，8： | 1 |
| 3 | Clinical outcomes of metallic stent insertion for obstructive colorectal cancer显示文摘 | Baik SH Kim NK Cho HW | 2006 | Hepatogastroenterology2006，53，68： | 1 |
| 4 | Effects of experimentally generated bull antisperm antibodies on in vitro fertilization显示文摘 | Kim CA Parrish JJ Momont HW | 1999 | Biol Reprod1999，60，6： | 1 |
| 5 | Serum highmobility group box-1 ( HMGB1) is closely associatedwith the clinical and pathologic features of gastriccancer显示文摘 | Chung HW Lee SG Kim H | 2009 | J Transl Med2009，7，： | 1 |
| 6 | Cardiovascular magnetic resonance in patients with myocardial infaretion: current and emerging applications 显示文摘 | KIM HW FARZANEH-FAR A KIM RJ | 2009 | J Am Coll Cardiol2009，55，1： | 1 |
| 7 | The financial burden of asthma:A nationwide comprehensive survey conducted in the republic of Korea显示文摘 | Kim CY Park HW Ko SK | | 0，，01： | 1 |
| 8 | Biomimetic approach to dental implants显示文摘 | Kim TI Jang JH Kim HW | | 0，，22： | 1 |
| 9 | Activation of the spinal sigma-! receptor enhances NMDA-induced pain via PKC- and PKA-dependent phosphorylation of the NR1 subunit in mice显示文摘 | Kim HW Roh DH Yoon SY | 2008 | Br J Pharmacol2008，154，5： | 1 |
| 10 | Measurement of three-dimensional perioral soft tissue changes in dentoalveolar protrusion patients after orthodontic treatment using a structured light scanner 显示文摘 | Ahn HW Chang YJ Kim KA | 2014 | Angle Or- thod2014，84，5： | 1 |
| 11 | Narrow-band ultraviolet B is a useful and well-tolerated treatment for vitiligo 显示文摘 | Scherschun L Kim JJ Lim HW | 2001 | J Am Acad Dermatol2001，44，6： | 1 |
| 12 | Early motor balance and coordination training increased synaptophysin in subcortical regions of the ischemic rat brain显示文摘 | Seo HG Kim DY Park HW | 2010 | J Korean Med Sci2010，25，11： | 1 |
| 13 | Preoperative evaluation of gallbladder carcinoma: efficacy of combined use of MR imaging, MR cholangiography, and contrast-enhanced dual-phase three-dimensional MR angiography显示文摘 | Kim JH Kim TK Eun HW | 2002 | J Magn Reson Imaging2002，16，6： | 1 |
| 14 | Investigation of inclusion complexation of paclitaxel by cyclohenicosakis-( 1 → 2 )-( β)-d-glucopyranosyl by cyclic-( 1 → 2 )-β-glucans ( cyclsophoranses ), and by cyclomahoheptaoses(β-cyclodextrins) 显示文摘 | Lee S Seo DH Kim HW | 2001 | Carbohydr Res2001，334，2： | 1 |
| 15 | Endotoxin-neutralizing antimicrobial proteins of the human placenta显示文摘 | Kim HS Cho JH Park HW | | 0，，05： | 1 |
| 16 | Role of the VEGF 936 C/T poly- morphism in diabetic microvascular complications in type 2 diabetic patients显示文摘 | Kim HW Ko GJ Kang YS | 2009 | Nephrology (Carlton)2009，14，7： | 1 |
| 17 | ALK-positive diffuse large B-cell lymphoma: report of three cases 显示文摘 | Lee HW Kim K Kim W | 2008 | Hematol Oncol2008，26，2： | 1 |
| 18 | Enhancement of nat- ural killer cell eytotoxicity by sodium/iodide symporter gene-mediated radioiodine pretreatment in breast cancer cells显示文摘 | Kim HW Kim JE Hwang MH | 2013 | PLoS One2013，8，8： | 1 |
| 19 | Hydroxyapatite and gelatin compos ite foams processed via novel freeze-drying and crosslinking for use as temporary hard tissue scaffolds 显示文摘 | Kim HW Knowles JC Kim HE | 2005 | J Biomed Mater Res A2005，72，2： | 1 |
| 20 | Artificial oxygen carriers as red blood cell substitutes:a selected review and current status显示文摘 | Kim HW Greenburg AG | 2004 | artif organs2004，28，9： | 1 |
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