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| 1 | An analytical investigation of the mechanics of spinal instrumentation显示文摘 | Kin YE Lin TH Weinstein JN | 1988 | Spine1988，13，： | 1 |
| 2 | Novel regulators of spermatogenesis显示文摘 | Kin Lam Fok Hao Chen Ye Chun Ruan Hsiao Chang Chan | 2014 | Seminars in Cell and Developmental Biology2014，，： | 1 |
| 3 | Epididymis cell atlas in a patient with a sex development disorder and a novel NR5A1 gene mutation显示文摘This study aims to characterize the cell atlas of the epididymis derived from a 46,XY disorders of sex development(DSD)patient with a novel heterozygous mutation of the nuclear receptor subfamily 5 group A member 1(NR5A1)gene.Next-generation sequencing found a heterozygous c.124C>G mutation in NR5A1 that resulted in a p.Q42E missense mutation in the conserved DNA-binding domain of NR5A1.The patient demonstrated feminization of external genitalia and Tanner stage 1 breast development.The surgical procedure revealed a morphologically normal epididymis and vas deferens but a dysplastic testis.Microfluidic-based single-cell RNA sequencing(scRNA-seq)analysis found that the fibroblast cells were significantly increased(approximately 46.5%),whereas the number of main epididymal epithelial cells(approximately 9.2%),such as principal cells and basal cells,was dramatically decreased.Bioinformatics analysis of cell–cell communications and gene regulatory networks at the single-cell level inferred that epididymal epithelial cell loss and fibroblast occupation are associated with the epithelial-to-mesenchymal transition(EMT)process.The present study provides a cell atlas of the epididymis of a patient with 46,XY DSD and serves as an important resource for understanding the pathophysiology of DSD. | Jian-Wu Shi Yi-Wen Zhou Yu-Fei Chen Mei Ye Feng Qiao Jia-Wei Tian Meng-Ya Zhang Hao-Cheng Lin Gang-Cai Xie Kin Lam Fok Hui Jiang Yang Liu Hao Chen | 2023 | Asian Journal of Andrology2023，25，1： | 0 |
| 4 | Remarkable synergistic effect in cobalt-iron nitride/alloy nanosheets for robust electrochemical water splitting显示文摘Design and synthesis of noble-metal-free bifunctional catalysts for efficient and robust electrochemical water splitting are of significant importance in developing clean and renewable energy sources for sustainable energy consumption.Herein,a simple three-step strategy is reported to construct cobalt-iron nitride/alloy nanosheets on nickel foam(CoFe-NA/NF)as a bifunctional catalyst for both hydrogen evolution reaction(HER)and oxygen evolution reaction(OER).The electrocatalyst with optimized composition(CoFe-NA2/NF)can achieve ultralow overpotentials of 73 mV and 250 mV for HER and OER,respectively,at a current density of 10 mA cm^(-2) in 1 M KOH.Notably,the electrolyzer based on this electrocatalyst is able to boost the overall water splitting with a cell voltage of 1.564 V to deliver 10 mA cm^(-2) for at least 50 h without obvious performance decay.Furthermore,our experiment and theoretical calculation demonstrate that the combination of cobalt-iron nitride and alloy can have low hydrogen adsorption energy and facilitate water dissociation during HER.In addition,the surface reconstruction introduces metal oxyhydroxides to optimize the OER process.Our work may pave a new pathway to design bifunctional catalysts for overall water splitting. | Mingpeng Chen Di Liu Baoye Zi Yuyun Chen Dong Liu Xinyu Du Feifei Li Pengfei Zhou Ye Ke Jielei Li Kin Ho Lo Chi Tat Kwok Weng Fai Ip Shi Chen Shuangpeng Wang Qingju Liu Hui Pan | 2022 | Journal of Energy Chemistry2022，31，2： | 0 |
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